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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 3
1957 6
1958 5
1959 3
1960 4
1961 3
1962 4
1965 19
1966 10
1967 22
1968 37
1969 32
1970 59
1971 71
1972 88
1973 84
1974 81
1975 45
1976 61
1977 38
1978 44
1979 46
1980 49
1981 52
1982 60
1983 28
1984 56
1985 44
1986 56
1987 54
1988 53
1989 48
1990 73
1991 54
1992 66
1993 71
1994 68
1995 91
1996 129
1997 123
1998 168
1999 185
2000 205
2001 230
2002 225
2003 195
2004 225
2005 230
2006 202
2007 275
2008 298
2009 280
2010 318
2011 322
2012 364
2013 343
2014 292
2015 325
2016 293
2017 278
2018 283
2019 112
2020 1
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6,955 results
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Page 1
Could Ceramides Become the New Cholesterol?
Summers SA. Cell Metab 2018 - Review. PMID 29307517 Free article.
The Mayo Clinic recently introduced a diagnostic test that quantifies plasma ceramides in order to identify patients at risk of major adverse cardiac events. By comparing recent discoveries about these biomarker ceramides with the exhaustive body of literature surrounding cholesterol, Summers aims to highlight important advances and critically needed areas of investigation on this exciting class of bioactive lipids....
The Mayo Clinic recently introduced a diagnostic test that quantifies plasma ceramides in order to identify patients at risk of major …
Visualizing bioactive ceramides.
Canals D, et al. Chem Phys Lipids 2018 - Review. PMID 30266560 Free PMC article.
In the last 30 years, ceramides have been found to mediate a myriad of biological processes. Ceramides have been recognized as bioactive molecules and their metabolizing enzymes are attractive targets in cancer therapy and other diseases. ...Recently, the 'Many Ceramides' hypothesis focuses on distinct pools of subcellular ceramides and ceramide species as potential defined bioactive entities. ...
In the last 30 years, ceramides have been found to mediate a myriad of biological processes. Ceramides have been recognized as …
Ceramides - Lipotoxic Inducers of Metabolic Disorders.
Chaurasia B and Summers SA. Trends Endocrinol Metab 2015 - Review. PMID 26412155
Of the myriad lipids that accrue under these conditions, sphingolipids such as ceramide or its metabolites are amongst the most deleterious because they disrupt insulin sensitivity, pancreatic β cell function, vascular reactivity, and mitochondrial metabolism. ...
Of the myriad lipids that accrue under these conditions, sphingolipids such as ceramide or its metabolites are amongst the most deleterious …
Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.
Petersen MC and Shulman GI. Trends Pharmacol Sci 2017 - Review. PMID 28551355 Free PMC article.
Diacylglycerols (DAGs) and ceramides have emerged as the two best-studied putative mediators of lipid-induced hepatic insulin resistance. ...In this review we examine the state of this field, turning a critical eye toward both DAGs and ceramides as putative mediators of lipid-induced hepatic insulin resistance....
Diacylglycerols (DAGs) and ceramides have emerged as the two best-studied putative mediators of lipid-induced hepatic insulin resista …
Ceramides and depression: A systematic review.
Dinoff A, et al. J Affect Disord 2017 - Review. PMID 28189963
The role of ceramides and other sphingolipids in depression is a novel concept. This review summarizes and evaluates the current state of evidence for a role of ceramides in depression pathophysiology and the potential for novel depression pharmacotherapies targeting ceramide metabolism. ...In human studies, ceramides C18:0 and C20:0 are the species most strongly linked to depression. Evidence for altered ceramide metabolism in depression is present, but data for a causal role of ceramides in depression are lacking. ...
The role of ceramides and other sphingolipids in depression is a novel concept. This review summarizes and evaluates the current stat …
Ceramide and Regulation of Vascular Tone
Cogolludo A, et al. Int J Mol Sci 2019 - Review. PMID 30669371 Free PMC article.
Sphingolipids in inflammatory hypoxia
Glaser UG and Fandrey J. Biol Chem 2018 - Review. PMID 29908122
Recent studies have identified acid sphingomyelinase (ASM), a central enzyme in the sphingolipid metabolism, as a regulator of several types of stress stimuli pathways and an important player in the tumor microenvironment. ...
Recent studies have identified acid sphingomyelinase (ASM), a central enzyme in the sphingolipid metabolism, as a regulator of severa …
Ceramide: a simple sphingolipid with unique biophysical properties
Castro BM, et al. Prog Lipid Res 2014 - Review. PMID 24513486
Ceramides are involved in a variety of cellular processes and in disease. Their biological functions are thought to depend on ceramides' unique biophysical properties, which promote strong alterations of cell membrane properties and consequent triggering of signaling events. ...In this review, a rationale for the multiple and complex changes promoted by ceramide is provided, highlighting, on a comprehensive and critical manner, the interactions between ceramides and specific lipids and/or lipid phases. ...
Ceramides are involved in a variety of cellular processes and in disease. Their biological functions are thought to depend on cera
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