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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1121
1844 1251
1845 1278
1846 1404
1847 1368
1848 1203
1849 1208
1850 1126
1851 1228
1852 1312
1853 1558
1854 1306
1855 1587
1856 1588
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1810
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2180
1878 2455
1879 2399
1880 2646
1881 3149
1882 2742
1883 3127
1884 3049
1885 3337
1886 3291
1887 3965
1888 4002
1889 4194
1890 4024
1891 3607
1892 4080
1893 4369
1894 3801
1895 4129
1896 4412
1897 4688
1898 4631
1899 4169
1900 3785
1901 3886
1902 3967
1903 3910
1904 4059
1905 4067
1906 3872
1907 4324
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5104
1914 5135
1915 4640
1916 4543
1917 4281
1918 4568
1919 4618
1920 4960
1921 4628
1922 4123
1923 4432
1924 4850
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5546
1933 5610
1934 5507
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4747
1945 20420
1946 53735
1947 64959
1948 70705
1949 62803
1950 85750
1951 103741
1952 108051
1953 108914
1954 105913
1955 108542
1956 107005
1957 111515
1958 109456
1959 109959
1960 112134
1961 120098
1962 125630
1963 141520
1964 162086
1965 176637
1966 179745
1967 191502
1968 207845
1969 215047
1970 218960
1971 222893
1972 227510
1973 230634
1974 234512
1975 248230
1976 250253
1977 249609
1978 257859
1979 265143
1980 266866
1981 271186
1982 282715
1983 294317
1984 302219
1985 318379
1986 330833
1987 346714
1988 362951
1989 376903
1990 381779
1991 379497
1992 380898
1993 388735
1994 400378
1995 409538
1996 419428
1997 416987
1998 434527
1999 451622
2000 487980
2001 500718
2002 518400
2003 546003
2004 588237
2005 647128
2006 691803
2007 729316
2008 776116
2009 814728
2010 876775
2011 951071
2012 1016847
2013 1067793
2014 1119790
2015 1160073
2016 1191932
2017 1212428
2018 1254595
2019 1311092
2020 1493192
2021 1632119
2022 1629826
2023 1534292
2024 1499549
2025 17463
2026 19

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35,540,979 results

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Page 1
Preface. Site-specific protein labeling.
Gautier A, Hinner MJ. Gautier A, et al. Methods Mol Biol. 2015;1266:v-viii. doi: 10.1007/978-1-4939-2272-7. Methods Mol Biol. 2015. PMID: 25710058 No abstract available.
Peptide chemistry toolbox - Transforming natural peptides into peptide therapeutics.
Erak M, Bellmann-Sickert K, Els-Heindl S, Beck-Sickinger AG. Erak M, et al. Bioorg Med Chem. 2018 Jun 1;26(10):2759-2765. doi: 10.1016/j.bmc.2018.01.012. Epub 2018 Jan 31. Bioorg Med Chem. 2018. PMID: 29395804 Review.
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became an emerging market in pharmaceutical industry. The need for synthetic
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicin …
Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems.
Yang LZ, Wang Y, Li SQ, Yao RW, Luan PF, Wu H, Carmichael GG, Chen LL. Yang LZ, et al. Mol Cell. 2019 Dec 19;76(6):981-997.e7. doi: 10.1016/j.molcel.2019.10.024. Epub 2019 Nov 19. Mol Cell. 2019. PMID: 31757757 Free article.
State-of-the-Art Biocatalysis.
Pyser JB, Chakrabarty S, Romero EO, Narayan ARH. Pyser JB, et al. ACS Cent Sci. 2021 Jul 28;7(7):1105-1116. doi: 10.1021/acscentsci.1c00273. Epub 2021 Jun 25. ACS Cent Sci. 2021. PMID: 34345663 Free PMC article. Review.
This evolution has been accelerated by developments in sequencing and DNA synthesis technology, bioinformatic and protein engineering tools, and the increasingly interdisciplinary nature of scientific research. Biocatalysis has become an indispensable tool applied i …
This evolution has been accelerated by developments in sequencing and DNA synthesis technology, bioinformatic and protein engineer
Eyes on Translation.
Chekulaeva M, Landthaler M. Chekulaeva M, et al. Mol Cell. 2016 Sep 15;63(6):918-25. doi: 10.1016/j.molcel.2016.08.031. Mol Cell. 2016. PMID: 27635758 Free article. Review.
Single-molecule folding.
Zhuang X, Rief M. Zhuang X, et al. Curr Opin Struct Biol. 2003 Feb;13(1):88-97. doi: 10.1016/s0959-440x(03)00011-3. Curr Opin Struct Biol. 2003. PMID: 12581665 Review.
Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction …
Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individua …
Protein Chemical Labeling Using Biomimetic Radical Chemistry.
Sato S, Nakamura H. Sato S, et al. Molecules. 2019 Nov 3;24(21):3980. doi: 10.3390/molecules24213980. Molecules. 2019. PMID: 31684188 Free PMC article. Review.
Chemical labeling of proteins with synthetic low-molecular-weight probes is an important technique in chemical biology. To achieve this, it is necessary to use chemical reactions that proceed rapidly under physiological conditions (i.e., aqueous solvent, pH, low con …
Chemical labeling of proteins with synthetic low-molecular-weight probes is an important technique in chemical biology. To ach …
Split-inteins and their bioapplications.
Li Y. Li Y. Biotechnol Lett. 2015 Nov;37(11):2121-37. doi: 10.1007/s10529-015-1905-2. Epub 2015 Jul 8. Biotechnol Lett. 2015. PMID: 26153348 Review.
Single-molecule RNA science.
Zhuang X. Zhuang X. Annu Rev Biophys Biomol Struct. 2005;34:399-414. doi: 10.1146/annurev.biophys.34.040204.144641. Annu Rev Biophys Biomol Struct. 2005. PMID: 15869396 Review.
The development of single-molecule detection and manipulation has allowed us to monitor the behavior of individual biological molecules and molecular complexes in real time. ...Exploring this capability to elucidate complex dynamics, recent single-molecule
The development of single-molecule detection and manipulation has allowed us to monitor the behavior of individual biological …
Expressed Protein Ligation: General Experimental Protocols.
Diaz J, Pellois JP. Diaz J, et al. Methods Mol Biol. 2020;2133:75-117. doi: 10.1007/978-1-0716-0434-2_5. Methods Mol Biol. 2020. PMID: 32144664
Expressed protein ligation allows for the attachment of a chemically labeled peptide to the N- or C-terminus of a recombinant protein. In this book chapter, the practical considerations involved in using this protein engineering technology are d
Expressed protein ligation allows for the attachment of a chemically labeled peptide to the N- or C-terminus of a recom
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