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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 9
1947 11
1948 4
1949 5
1950 27
1951 47
1952 10
1953 16
1954 10
1955 13
1956 8
1957 6
1958 7
1959 12
1960 5
1961 9
1962 17
1963 217
1964 434
1965 285
1966 226
1967 239
1968 303
1969 348
1970 390
1971 455
1972 432
1973 507
1974 494
1975 465
1976 473
1977 435
1978 396
1979 422
1980 397
1981 385
1982 372
1983 419
1984 445
1985 491
1986 462
1987 448
1988 407
1989 410
1990 395
1991 386
1992 405
1993 387
1994 331
1995 390
1996 340
1997 388
1998 373
1999 380
2000 398
2001 433
2002 475
2003 541
2004 459
2005 515
2006 584
2007 703
2008 672
2009 732
2010 920
2011 933
2012 1042
2013 1026
2014 1275
2015 1220
2016 1194
2017 1211
2018 1143
2019 685
2020 22
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29,068 results
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Page 1
Drug-Induced Liver Injury
Fisher K, et al. Arch Pathol Lab Med 2015 - Review. PMID 26125428
CONTEXT: Drug-induced liver injury (DILI) represents a diverse set of responses following exposure to any manufactured or naturally occurring chemical compound. ...Accurate diagnosis requires establishing a causal relationship with the suspected agent and excluding competing causes of liver injury. ...
CONTEXT: Drug-induced liver injury (DILI) represents a diverse set of responses following exposure to any manufactured or natu …
Drug-induced liver injury
Katarey D and Verma S. Clin Med (Lond) 2016 - Review. PMID 27956449 Free PMC article.
In the absence of diagnostic tests and/or biomarkers, the diagnosis of DILI requires a high index of suspicion after diligently excluding other causes of abnormal liver tests. Antibiotics are the class of drugs most frequently associated with idiosyncratic DILI, although recent studies indicate that herbal and dietary supplements are an increasingly recognised cause. ...
In the absence of diagnostic tests and/or biomarkers, the diagnosis of DILI requires a high index of suspicion after
Drug-induced Liver Injury: The Hepatic Pathologist's Approach.
Kleiner DE. Gastroenterol Clin North Am 2017 - Review. PMID 28506365 Free PMC article.
The findings can be analyzed with respect to the various prescription and nonprescription medications and dietary supplements under suspicion to provide a complete interpretation of the findings. The pathologic findings, the histologic differential diagnosis, and expert interpretation are part of a complete biopsy assessment and provide information that is of greatest value in patient management....
The findings can be analyzed with respect to the various prescription and nonprescription medications and dietary suppl …
Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.
McGill MR and Jaeschke H. Expert Rev Mol Diagn 2018 - Review. PMID 30080986 Free PMC article.
Expert commentary: There are major obstacles to DILI biomarker development and implementation, including the low prevalence of idiosyncratic DILI (IDILI), weak associations of IDILI with genetic variants, and lack of specificity of many biomarkers for the liver. ...Future research should focus on implementation of biomarkers to predict later injury and outcome in early presenters with intrinsic DILI, and on development of biomarkers of adaptation and repair in the liver that can be used to determine if a liver test abnormality is likely to be clinically significant in IDILI....
Expert commentary: There are major obstacles to DILI biomarker development and implementation, including the low prevalence of …
Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis.
Iorga A, et al. Int J Mol Sci 2017 - Review. PMID 28486401 Free PMC article.
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). ...We also explore what is known about the genetic basis of IDILI and the molecular pathways leading to immune activation and how these events can trigger hepatotoxicity and cell death....
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as acetaminophen (A
Corticosteroid therapy in drug-induced liver injury: Pros and cons.
Hu PF and Xie WF. J Dig Dis 2019 - Review. PMID 30582289
Drug-induced liver injury (DILI) is a liver toxicity induced by a drug or its metabolite. The incidence of DILI continues to increase and it has been an enormous challenge worldwide, while the prognosis is not optimistic. ...In this review, we summarized the history and current status of corticosteroid use in liver diseases and the pros and cons of corticosteroid treatment in DILI, and we explored the DILI candidates who may benefit from corticosteroid therapy, the administration route and dosage, and the adverse effects related to corticosteroid use....
Drug-induced liver injury (DILI) is a liver toxicity induced by a drug or its metabolite. The incidence of DILI continues to i …
MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.
Howell LS, et al. Expert Rev Mol Diagn 2018 - Review. PMID 29235390
Drug-induced liver injury (DILI) is a severe adverse drug reaction which is of major concern to patients, clinicians and the pharmaceutical industry. Accurate and rapid detection of DILI is important for patient stratification and treatment in the clinic and benefits preclinical drug design and risk assessment. ...
Drug-induced liver injury (DILI) is a severe adverse drug reaction which is of major concern to patients, clinicians and
RUCAM in Drug and Herb Induced Liver Injury: The Update.
Danan G and Teschke R. Int J Mol Sci 2015 - Review. PMID 26712744 Free PMC article.
In many countries and for more than two decades, physicians, regulatory agencies, case report authors, and pharmaceutical companies successfully applied RUCAM for suspected DILI and HILI. ...We now present the update of the well accepted original RUCAM scale and recommend its use for clinical, regulatory, publication, and expert purposes to validly establish causality in cases of suspected DILI and HILI, facilitating a straightforward application and an internationally harmonized approach of causality assessment as a common basic tool....
In many countries and for more than two decades, physicians, regulatory agencies, case report authors, and pharm …
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
Chalasani N, et al. Gastroenterology 2015 - Clinical Trial. PMID 25754159 Free PMC article.
Additional studies are needed to confirm the association between azithromycin and increased DILI in patients with chronic liver disease. Older age and short or long latencies are not associated with DILI mortality....
Additional studies are needed to confirm the association between azithromycin and increased DILI in patie
Drug-, herb- and dietary supplement-induced liver injury.
Cavalieri ML and D'Agostino D. Arch Argent Pediatr 2017. PMID 29087122 Free article.
Drug- and substance-induced liver injury accounts for approximately 20% of pediatric cases of acute liver failure. It is caused by two mechanisms: direct and idiosyncratic hepatotoxicity. Direct hepatotoxicity is the result of the administration of a drug with intrinsic toxicity and is dose-dependent (e.g., acetaminophen). ...
Drug- and substance-induced liver injury accounts for approximately 20% of pediatric cases of acute liver failur …
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