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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1970 1
1972 1
1976 2
1977 3
1978 1
1981 2
1982 2
1983 1
1984 2
1985 2
1987 1
1988 2
1989 4
1990 2
1991 2
1993 2
1995 1
1996 1
1997 3
1998 2
1999 2
2000 3
2001 7
2002 12
2003 8
2004 7
2005 11
2006 16
2007 25
2008 21
2009 35
2010 68
2011 57
2012 77
2013 90
2014 144
2015 131
2016 136
2017 126
2018 107
2019 72
2020 3
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1,034 results
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Page 1
Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.
McGill MR and Jaeschke H. Expert Rev Mol Diagn 2018 - Review. PMID 30080986 Free PMC article.
The difficulty of understanding and diagnosing drug-induced liver injury (DILI) has led to proliferation of serum and genetic biomarkers. ...Future research should focus on implementation of biomarkers to predict later injury and outcome in early presenters with intrinsic DILI, and on development of biomarkers of adaptation and repair in the liver that can be used to determine if a liver test abnormality is likely to be clinically significant in IDILI....
The difficulty of understanding and diagnosing drug-induced liver injury (DILI) has led to proliferation of seru …
Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives.
Kuna L, et al. Curr Drug Metab 2018 - Review. PMID 29788883 Free PMC article.
BACKGROUND: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases. ...
BACKGROUND: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the Un …
Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.
Fontana RJ. Gastroenterology 2014 - Review. PMID 24389305 Free PMC article.
Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of drug dose, route, or duration of administration. ...
Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of drug dose …
Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review.
Stine JG and Lewis JH. Expert Rev Gastroenterol Hepatol 2016 - Review. PMID 26633044 Free PMC article.
While the pace of discovery of new agents, mechanisms and risk factors involved in drug-induced liver injury (DILI) remains brisk, advances in the treatment of acute DILI seems slow by comparison. ...For drug-induced acute liver failure, the use of liver support systems is still investigational in the United States and emergency liver transplant remains limited by its availability. ...
While the pace of discovery of new agents, mechanisms and risk factors involved in drug-induced liver injury (DI …
LncRNA-Regulated Autophagy and its Potential Role in Drug-Induced Liver Injury.
Zhou J, et al. Ann Hepatol 2018 - Review. PMID 29735795 Free article.
This study aimed to review recently published studies and further describe the long noncoding RNA (lncRNA)-regulated autophagy during drug-induced liver injury (DILI). ...RESULTS: Many studies explicitly indicated that DILI and its progression to acute liver failure were causatively linked to endoplasmic reticulum stress and subsequently induced autophagy, which protect hepatocytes during DILI. ...
This study aimed to review recently published studies and further describe the long noncoding RNA (lncRNA)-regulated autophagy during dru
Phenotypes and Pathology of Drug-Induced Liver Disease.
Goodman ZD. Clin Liver Dis 2017 - Review. PMID 27842777
Drug hepatotoxicity can simulate nearly any clinical syndrome or pathologic lesion that may occur in the liver, so clinical and histopathologic diagnosis of drug-induced liver injury may be difficult. ...Recognition of these patterns or phenotypes in liver biopsy material is helpful in evaluation of clinical cases of suspected drug-induced liver injury....
Drug hepatotoxicity can simulate nearly any clinical syndrome or pathologic lesion that may occur in the liver, so clinical an
Role of miRNA and its potential as a novel diagnostic biomarker in drug-induced liver injury.
Sanjay S and Girish C. Eur J Clin Pharmacol 2017 - Review. PMID 28028586
This review summarises some of the latest findings about the biological functions of miRNA and its potential use as diagnostic biomarkers in drug- induced liver injury. METHODS: The information presented in this article is taken from published literature, both original work and reviews on mechanisms of drug- induced liver injury, miRNA in liver pathophysiology, and studies exploring the use of miRNA as biomarker in drug- induced liver injury. ...
This review summarises some of the latest findings about the biological functions of miRNA and its potential use as diagnostic biomarkers in …
Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis.
Dong S, et al. J Toxicol Sci 2016. PMID 27452039 Free article.
However, the toxicological mechanisms of CCl4-induced liver fibrosis remain not fully understood. We combined transcriptomic and proteomic analysis and biological network technology, predicted toxicological targets and regulatory networks of CCl4 in liver fibrosis. ...Therefore, the toxicological mechanisms of CCl4-induced liver fibrosis may be related with multi biological process, pathway and targets which may provide potential protection reaction mechanism for CCl4 detoxication in the liver....
However, the toxicological mechanisms of CCl4-induced liver fibrosis remain not fully understood. We combined transcriptomic a …
Prediction of drug-induced liver injury using keratinocytes.
Hirashima R, et al. J Appl Toxicol 2017. PMID 28138970 Free PMC article.
Drug-induced liver injury (DILI) is one of the most common adverse drug reactions. DILI is often accompanied by skin reactions, including rash and pruritus. However, it is still unknown whether DILI-associated genes such as S100 calcium-binding protein A and interleukin (IL)-1β are involved in drug-induced skin toxicity. ...
Drug-induced liver injury (DILI) is one of the most common adverse drug reactions. DILI is often accompan
Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.
Roth AD and Lee MY. Biomed Res Int 2017 - Review. PMID 28133614 Free PMC article.
Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug recall and acute liver failure (ALF) in the United States. While current drug development processes emphasize general toxicity and drug metabolizing enzyme- (DME-) mediated toxicity, it has been challenging to develop comprehensive models for assessing complete idiosyncratic potential. ...
Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug recall and acute liver
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