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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1964 5
1965 14
1966 30
1967 38
1968 48
1969 45
1970 44
1971 62
1972 51
1973 95
1974 70
1975 65
1976 75
1977 56
1978 60
1979 66
1980 30
1981 36
1982 44
1983 46
1984 50
1985 57
1986 53
1987 53
1988 48
1989 59
1990 71
1991 49
1992 57
1993 65
1994 56
1995 45
1996 56
1997 51
1998 59
1999 60
2000 82
2001 82
2002 84
2003 90
2004 78
2005 105
2006 110
2007 115
2008 130
2009 193
2010 329
2011 374
2012 405
2013 421
2014 543
2015 514
2016 488
2017 504
2018 471
2019 258
2020 9
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6,498 results
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Page 1
Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.
McGill MR and Jaeschke H. Expert Rev Mol Diagn 2018 - Review. PMID 30080986 Free PMC article.
The difficulty of understanding and diagnosing drug-induced liver injury (DILI) has led to proliferation of serum and genetic biomarkers. ...Future research should focus on implementation of biomarkers to predict later injury and outcome in early presenters with intrinsic DILI, and on development of biomarkers of adaptation and repair in the liver that can be used to determine if a liver test abnormality is likely to be clinically significant in IDILI....
The difficulty of understanding and diagnosing drug-induced liver injury (DILI) has led to proliferation of seru …
Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives.
Kuna L, et al. Curr Drug Metab 2018 - Review. PMID 29788883 Free PMC article.
BACKGROUND: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases. ...
BACKGROUND: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the Un …
MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.
Howell LS, et al. Expert Rev Mol Diagn 2018 - Review. PMID 29235390
Drug-induced liver injury (DILI) is a severe adverse drug reaction which is of major concern to patients, clinicians and the pharmaceutical industry. ...Furthermore, the use of miRNAs as potential markers of progression of DILI and specific zonated damage within the liver is discussed. ...
Drug-induced liver injury (DILI) is a severe adverse drug reaction which is of major concern to patients,
Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis.
Iorga A, et al. Int J Mol Sci 2017 - Review. PMID 28486401 Free PMC article.
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury from drug hepatotoxicity (whether idiosyncratic or predictable) results in hepatocyte cell death and inflammation. ...
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as acetaminophe
Serum biomarkers of drug-induced liver injury: Current status and future directions.
Church RJ and Watkins PB. J Dig Dis 2019 - Review. PMID 30378260
Drug-induced liver injury (DILI), which is caused by drugs and herbal or dietary supplements, remains a serious concern for drug developers, regulators, and clinicians; however, serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations. Data-driven mathematical modeling that incorporates the release and clearance kinetics of traditional biomarkers has improved their use in the prediction of liver safety liabilities for new drug candidates. ...
Drug-induced liver injury (DILI), which is caused by drugs and herbal or dietary supplements, remains a serious
Molecular Research on Drug Induced Liver Injury.
Teschke R and Danan G. Int J Mol Sci 2018. PMID 29324638 Free PMC article.
Drugs may cause liver injury in a few susceptible individuals, but the molecular events that lead to this idiosyncratic, largely dose-independent and non-predictable drug-induced liver injury (DILI) are mostly unknown, since animal models to explore the pathogenetic mechanisms of human idiosyncratic DILI are not yet reliable.[...]....
Drugs may cause liver injury in a few susceptible individuals, but the molecular events that lead to this idiosyncratic, large …
The diagnostic role of miR-122 in drug-induced liver injury: A systematic review and meta-analysis.
Liu Y, et al. Medicine (Baltimore) 2018 - Review. PMID 30544438 Free PMC article.
BACKGROUND: Drug-induced liver injury (DILI) is a potentially severe adverse drug reaction especially in susceptible patients. ...While in acetaminophen (APAP)-induced liver injury, the sensitivity was [0.82 (95%CI, 0.67-0.91), I = 65.77%] specificity was [0.96 (95%CI, 0.88-0.99), I = 31.46%], AUROC was 0.97 (95% CI, 0.95-0.98). ...
BACKGROUND: Drug-induced liver injury (DILI) is a potentially severe adverse drug reaction especially in …
Biomarkers of drug-induced liver injury.
McGill MR and Jaeschke H. Adv Pharmacol 2019 - Review. PMID 31307588
Drug-induced liver injury (DILI) is a major clinical and regulatory challenge. As a result, interest in DILI biomarkers is growing. ...Although much work has been done, more liver-specific biomarkers, more DILI-specific biomarkers, and better prognostic biomarkers for survival are all still needed. ...
Drug-induced liver injury (DILI) is a major clinical and regulatory challenge. As a result, interest in DILI bio
Drug-induced Cholestasis: Mechanisms, Models, and Markers.
Chatterjee S and Annaert P. Curr Drug Metab 2018 - Review. PMID 29708070
BACKGROUND: Drug-induced cholestasis is a risk factor in the progression of drug candidates, and poses a serious health hazard if not detected before going into a human. ...Significant overlap in biomarker signatures between different mechanisms of Drug-induced Liver Injury (DILI) precludes identification of specific mechanisms. ...
BACKGROUND: Drug-induced cholestasis is a risk factor in the progression of drug candidates, and poses a serious health …
Idiosyncratic Drug-Induced Liver Injury: Is Drug-Cytokine Interaction the Linchpin?
Roth RA, et al. J Pharmacol Exp Ther 2017 - Review. PMID 28104833
Idiosyncratic drug-induced liver injury continues to be a human health problem in part because drugs that cause these reactions are not identified in current preclinical testing and because progress in prevention is hampered by incomplete knowledge of mechanisms that underlie these adverse responses. ...In this short review, we propose that the interaction of drugs with these cytokines contributes to idiosyncratic drug-induced liver injury, and mechanisms by which this could occur are discussed....
Idiosyncratic drug-induced liver injury continues to be a human health problem in part because drugs that cause …
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