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Year Number of Results
1990 2
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1993 1
1994 3
1995 2
1996 5
1997 7
1998 3
1999 2
2000 10
2001 6
2002 7
2003 11
2004 3
2005 3
2006 11
2007 8
2008 19
2009 7
2010 3
2011 9
2012 10
2013 20
2014 11
2015 7
2016 9
2017 15
2018 9
2019 3
2020 0
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187 results
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Page 1
The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System.
García-Domínguez M, et al. Cell Mol Neurobiol 2019. PMID 31203533
Apart from its involvement in immune functions, the chemokine CCL1 can participate in the modulation of nociceptive processing. ...The detection by ELISA of an increased presence of the endocannabinoid 2-arachidonoylglycerol after the administration of an analgesic dose of CCL1 supports the notion that CCL1 can evoke thermal analgesia through the release of this endocannabinoid from circulating leukocytes....
Apart from its involvement in immune functions, the chemokine CCL1 can participate in the modulation of nociceptive processing …
CCL1 is a major regulatory T cell attracting factor in human breast cancer.
Kuehnemuth B, et al. BMC Cancer 2018. PMID 30572845 Free PMC article.
Chemokine expression and tumor infiltration by regulatory T cells, determined by expression of the transcription factor FoxP3, were quantified and their correlation to clinical features was statistically analyzed. RESULTS: Both CCL1 and CCL22 were expressed in most breast cancer tissues. CCL1 was significantly over-expressed in invasive breast cancer as compared to normal breast tissue. ...
Chemokine expression and tumor infiltration by regulatory T cells, determined by expression of the transcription factor FoxP3, were q
CCR8+FOXp3+ Treg cells as master drivers of immune regulation
Barsheshet Y, et al. Proc Natl Acad Sci U S A 2017. PMID 28533380 Free PMC article.
We show that in human peripheral blood cells, more than 30% of T(reg) up-regulate CCR8 following activation in the presence of CCL1. ...Of the four human CCR8 ligands, CCL1 is unique in potentiating T(reg) cells. The relevance of these observations has been extended using an experimental model of multiple sclerosis [experimental autoimmune encephalomyelitis, (EAE)] and a stabilized version of mouse CCL1 (CCL1-Ig). ...
We show that in human peripheral blood cells, more than 30% of T(reg) up-regulate CCR8 following activation in the presence of CCL1. …
Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8.
Noda M, et al. Neurochem Int 2018. PMID 29248693
In addition, RAP-103 at a concentration of 0.1 pM completely inhibits membrane ruffling and phagocytosis induced by chemokine (C-C motif) ligand 1 (CCL1), an agonist for CCR8. It has been shown that CCL1/CCR8 signaling is important in tactile allodynia induced by nerve ligation. Therefore, CCR8, among other chemokine receptors such as CCR2/CCR5, could be the most potent target for RAP-103. ...
In addition, RAP-103 at a concentration of 0.1 pM completely inhibits membrane ruffling and phagocytosis induced by chemokine (C-C mo …
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
Ito M, et al. Nature 2019. PMID 30602786
The amplification of brain T(reg) cells is dependent on interleukin (IL)-2, IL-33, serotonin and T cell receptor recognition, and infiltration into the brain is driven by the chemokines CCL1 and CCL20. ...
The amplification of brain T(reg) cells is dependent on interleukin (IL)-2, IL-33, serotonin and T cell receptor recognition, and infiltrati …
Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target - Evidence from a mouse diabetic neuropathy model.
Zychowska M, et al. Int Immunopharmacol 2017. PMID 28961489
BACKGROUND: Chemokine signaling has been implicated in the pathogenesis of diabetic neuropathy; however, the involvement of the chemokine CC motif ligand 1 (CCL1)-chemokine CC motif receptor 8 (CCR8) interaction remains unknown. ...Lipopolysaccharide stimulation of primary microglial cultures resulted in decreases in the levels of CCL1 and CCR8. Single intrathecal injection of CCL1 (10-500ng) induced the development of hypersensitivity, whereas on day 7 after STZ, a CCL1-neutralizing antibody dose-dependently (2-8μg) delayed pain behavior. ...
BACKGROUND: Chemokine signaling has been implicated in the pathogenesis of diabetic neuropathy; however, the involvement of the ch
Total chemical synthesis and biological activities of glycosylated and non-glycosylated forms of the chemokines CCL1 and Ser-CCL1.
Okamoto R, et al. Angew Chem Int Ed Engl 2014. PMID 24644239
CCL1 is a naturally glycosylated chemokine protein that is secreted by activated T-cells and acts as a chemoattractant for monocytes. ...To the best of our knowledge, these are the first investigations of the effect of glycosylation on the chemotactic activity of the chemokine (Ser-)CCL1 using homogeneous N-glycosylated protein molecules of defined covalent structure....
CCL1 is a naturally glycosylated chemokine protein that is secreted by activated T-cells and acts as a chemoattractant for mon
CC chemokine CCL1 receptor CCR8 mediates conversion of mesenchymal stem cells to embryoid bodies expressing FOXP3+CCR8+ regulatory T cells.
Haque NS, et al. PLoS One 2019. PMID 31314754 Free PMC article.
Here we show that rat MSCs form EBs; which express regulatory T cell (Treg) marker Foxp3 and CC chemokine CCL1 receptor CCR8. We show a novel method for formation of EBs from MSCs under stress and demonstrate that the induction of FoxP3+ CCR8+ EBs is dependent upon CCL1 gradients which mediate cell proliferation, migration and invasion of mTregs. ...
Here we show that rat MSCs form EBs; which express regulatory T cell (Treg) marker Foxp3 and CC chemokine CCL1 receptor CCR8. …
(Quasi-)racemic X-ray structures of glycosylated and non-glycosylated forms of the chemokine Ser-CCL1 prepared by total chemical synthesis.
Okamoto R, et al. Angew Chem Int Ed Engl 2014. PMID 24692304
Our goal was to obtain the X-ray crystal structure of the glycosylated chemokine Ser-CCL1. Glycoproteins can be hard to crystallize because of the heterogeneity of the oligosaccharide (glycan) moiety. ...A racemic mixture of the protein enantiomers L-Ser-CCL1 and D-Ser-CCL1 was also crystallized, and the structure of the true racemate was solved at a resolution of 2.7-2.15 Å. ...
Our goal was to obtain the X-ray crystal structure of the glycosylated chemokine Ser-CCL1. Glycoproteins can be hard to crysta …
In vitro selection of RNA aptamers that block CCL1 chemokine function.
Marro ML, et al. Biochem Biophys Res Commun 2006. PMID 16930539
CCL1, the CCR8 ligand, is a CC chemokine secreted by activated monocytes and lymphocytes and is a potent chemoattractant for these cell types. ...To our knowledge, the T48 aptamer constitutes one of the most potent CCL1 antagonists reported to date and is an excellent tool to dissect CCL1-specific function in vivo. ...
CCL1, the CCR8 ligand, is a CC chemokine secreted by activated monocytes and lymphocytes and is a potent chemoattractant for t
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