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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1992 9
1993 13
1994 8
1995 11
1996 31
1997 51
1998 112
1999 114
2000 119
2001 92
2002 98
2003 92
2004 88
2005 90
2006 87
2007 104
2008 100
2009 94
2010 113
2011 126
2012 114
2013 115
2014 119
2015 104
2016 78
2017 59
2018 62
2019 27
2020 1
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2,023 results
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Page 1
The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers.
Staversky RJ, et al. Sci Rep 2018. PMID 30279500 Free PMC article.
The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population, and leukemia progression. ...CCL3(-/-) mice were used to evaluate the role of CCL3 in regulating hematopoietic stem and progenitor cell (HSPC) populations. ...
The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In …
The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.
Marciniak E, et al. Sci Rep 2015. PMID 26511387 Free PMC article.
While chemokine upsurge has been associated with conditions characterized with cognitive impairments, their ability to modulate synaptic plasticity remains ill-defined. ...These effects of CCL3 on memory were inhibited by Maraviroc. Altogether, these data suggest that the chemokine CCL3 is an hippocampal neuromodulator able to regulate synaptic plasticity mechanisms involved in learning and memory functions....
While chemokine upsurge has been associated with conditions characterized with cognitive impairments, their ability to modulate synap …
Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.
Mitchell DA, et al. Nature 2015 - Clinical Trial. PMID 25762141 Free PMC article.
In mice, Td pre-conditioning also enhanced bilateral DC migration and suppressed tumour growth in a manner dependent on the chemokine CCL3. ...
In mice, Td pre-conditioning also enhanced bilateral DC migration and suppressed tumour growth in a manner dependent on the chemokine
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
Kang SS, et al. J Exp Med 2018. PMID 30082275 Free PMC article.
Using this approach in models of amyloidosis, tauopathy, and aging, we revealed a common set of alterations and identified a central APOE-driven network that converged on CCL3 and CCL4 across all conditions. ...
Using this approach in models of amyloidosis, tauopathy, and aging, we revealed a common set of alterations and identified a central APOE-dr …
Chemokines as adjuvants for immunotherapy: implications for immune activation with CCL3.
Schaller TH, et al. Expert Rev Clin Immunol 2017 - Review. PMID 28965431 Free PMC article.
Areas covered: In this review, we provide an overview of chemokines in pathogen and anti-tumor immune responses and discuss further improving immunotherapies by arming particular chemokine axes. Expert commentary: The chemokine macrophage inflammatory protein-1 alpha (MIP-1α, CCL3) has emerged as a potent activator of both innate and adaptive responses. ...
Areas covered: In this review, we provide an overview of chemokines in pathogen and anti-tumor immune responses and discuss further improvin …
Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells.
Takahashi T, et al. Environ Toxicol Pharmacol 2019. PMID 31260942
We previously reported that brain-specific expression of chemokine CCL3 increases in mice administered methylmercury. However, the relationship between CCL3 and methylmercury toxicity has not been elucidated. Here, we confirmed that induction of CCL3 expression occurs before pathological change by methylmercury treatment was observed in the mouse brain. ...
We previously reported that brain-specific expression of chemokine CCL3 increases in mice administered methylmercury. However, …
Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma
Teufel M, et al. Gastroenterology 2019. PMID 30738047 Free article.
RESULTS: Decreased baseline plasma concentrations of 5 of 266 evaluable proteins (angiopoietin 1, cystatin B, the latency-associated peptide of transforming growth factor beta 1, oxidized low-density lipoprotein receptor 1, and C-C motif chemokine ligand 3; adjusted P ≤ .05) were significantly associated with increased overall survival time after regorafenib treatment. ...
RESULTS: Decreased baseline plasma concentrations of 5 of 266 evaluable proteins (angiopoietin 1, cystatin B, the latency-associated peptide …
CCL3 chemokine expression by chronic lymphocytic leukemia cells orchestrates the composition of the microenvironment in lymph node infiltrates.
Hartmann EM, et al. Leuk Lymphoma 2016. PMID 26458057 Free PMC article.
To further dissect these interactions in situ, we analyzed lymph nodes from 43 different patients infiltrated by CLL cells for expression of the chemokine CCL3, Ki-67, macrophages, and T cell subsets by immunohistochemistry. CCL3 expression was detected in 24 of 43 cases (56%), particularly in prolymphocytes and paraimmunoblasts within the proliferation centers. ...
To further dissect these interactions in situ, we analyzed lymph nodes from 43 different patients infiltrated by CLL cells for expression of …
Role of interleukin-4, the chemokine CCL3 and its receptor CCR5 in neuropathic pain.
Sun S, et al. Mol Immunol 2016. PMID 27522478
In this study, we investigated the role of interleukin-4 and the chemokine/chemokine receptor pair CCL3/CCR5 in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain. ...CCI-induced neuropathic pain was associated with CCL3 and CCR5 upregulation and microglial activation. Intrathecal injection of the anti-inflammatory cytokine interleukin-4 or CCL3-neutralizing antibody alleviated CCI-induced inflammation, suppressing the CCI-induced upregulation of tumor necrosis factor-α and interleukin-1β in the serum and spinal cord, restoring the CCI-induced upregulation of CCL3 and CCR5, and suppressing the CCI-induced activation of p38 mitogen-activated protein kinase. ...
In this study, we investigated the role of interleukin-4 and the chemokine/chemokine receptor pair CCL3/CCR5 in a mouse …
CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages.
Kitamura T, et al. J Exp Med 2015. PMID 26056232 Free PMC article.
We demonstrate here that, through activation of the CCL2 receptor CCR2, the recruited MAMs secrete another chemokine ligand CCL3. Genetic deletion of CCL3 or its receptor CCR1 in macrophages reduces the number of lung metastasis foci, as well as the number of MAMs accumulated in tumor-challenged lung in mice. ...
We demonstrate here that, through activation of the CCL2 receptor CCR2, the recruited MAMs secrete another chemokine ligand CCL3
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