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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 9
1991 14
1992 27
1993 45
1994 50
1995 80
1996 114
1997 127
1998 181
1999 182
2000 200
2001 183
2002 156
2003 157
2004 146
2005 166
2006 131
2007 102
2008 59
2009 42
2010 54
2011 65
2012 65
2013 55
2014 58
2015 71
2016 52
2017 49
2018 56
2019 22
2020 1
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2,572 results
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Page 1
Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment
Hofmann SR, et al. Curr Osteoporos Rep 2017 - Review. PMID 29080202 Free PMC article.
In this context, we present previously unpublished data on cytokine and chemokine expression in monocytes and tissues. CNO/CRMO is an autoinflammatory bone disorder resulting from imbalanced cytokine expression from innate immune cells. ...
In this context, we present previously unpublished data on cytokine and chemokine expression in monocytes and tissues. CNO/CRMO is an …
Chemokine CCL4 Induces Vascular Endothelial Growth Factor C Expression and Lymphangiogenesis by miR-195-3p in Oral Squamous Cell Carcinoma.
Lien MY, et al. Front Immunol 2018. PMID 29599774 Free PMC article.
The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. ...However, it is unclear as to whether CCL4 correlates with VEGF-C expression and lymphangiogenesis in OSCC. We found that CCL4 increased VEGF-C expression and promoted lymphangiogenesis in oral cancer cells in vitro and in vivo. miR-195-3p mimic reversed CCL4-enhanced VEGF-C expression. ...
The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. …
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4(+) Lymphocytes and Met-Enkephalin.
García-Domínguez M, et al. Mol Neurobiol 2019. PMID 29907903
In the present study, we characterize the antinociceptive effects produced by the chemokine CCL4 in mice. The intraplantar administration of very low doses of CCL4 (0.1-3 pg) produced bilateral antinociception assessed by the unilateral hot-plate test (UHP) without evoking chemotactic responses at the injection site. ...In accordance, plasma levels of met-enkephalin, but not β-endorphin, were augmented in response to CCL4. Likewise, CCL4-evoked antinociception was blocked by the administration of an anti-met-enk antibody. ...
In the present study, we characterize the antinociceptive effects produced by the chemokine CCL4 in mice. The intraplantar adm …
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
Kang SS, et al. J Exp Med 2018. PMID 30082275 Free PMC article.
Using this approach in models of amyloidosis, tauopathy, and aging, we revealed a common set of alterations and identified a central APOE-driven network that converged on CCL3 and CCL4 across all conditions. ...
Using this approach in models of amyloidosis, tauopathy, and aging, we revealed a common set of alterations and identified a central APOE-dr …
MicroRNA-125b modulates inflammatory chemokine CCL4 expression in immune cells and its reduction causes CCL4 increase with age.
Cheng NL, et al. Aging Cell 2015. PMID 25620312 Free PMC article.
Here, we report the role of microRNA-125b (miR-125b) in regulating inflammatory CC chemokine 4 (CCL4) expression in human immune cells and its altered expression with aging. ...We observed that monocytes and naïve CD8 T cells expressed higher levels of CCL4 and exhibited an age-related increase in CCL4. ...
Here, we report the role of microRNA-125b (miR-125b) in regulating inflammatory CC chemokine 4 (CCL4) expression in human immu …
MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease.
Ohukainen P, et al. Ann Med 2015. PMID 26203686
This revealed changes especially in genes related to inflammation and immune response, including chemokine (C-C motif) ligand 3 (CCL3) and 4 (CCL4). ...Both CCL3 and CCL4 localized to macrophages by immunofluorescence. To identify chemokine-miRNA target pairs, data from miRNA target prediction databases were combined with valvular miRNA and mRNA expression profiles. ...
This revealed changes especially in genes related to inflammation and immune response, including chemokine (C-C motif) ligand 3 (CCL3 …
The relationship between chemokines CCL2, CCL3, and CCL4 with the tumor microenvironment and tumor-associated macrophage markers in colorectal cancer.
De la Fuente López M, et al. Tumour Biol 2018. PMID 30419802
The aim of this study was to investigate the relation between tissue and plasma chemokine levels involved in macrophage recruitment with tumor-associated macrophage profile markers and clinicopathological features such as tumor-node-metastases stage, desmoplasia, tumor necrosis factor-α, and vascular endothelial growth factor plasma content. ...Chemokines were evaluated from tissue lysates (CCL2, CCL3, CCL4, CCL5, and CX3CL1) by Luminex. Statistical analysis was performed using Wilcoxon match-paired test ( p  < 0.05). ...
The aim of this study was to investigate the relation between tissue and plasma chemokine levels involved in macrophage recruitment w …
SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study.
Zhang Z, et al. PLoS One 2018. PMID 29927949 Free PMC article.
We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide family association study. ...SNPs rs1129844 in CCL11 and rs1719152 in CCL4 were associated with elevated plasma chemokine levels in FM. In a transmission disequilibrium test (TDT), rs1129844 was unequally transmitted from parents to their affected children (p< 0.0074), while the CCL4 SNP was not. ...
We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide family association study. . …
TNF-α Drives the CCL4 Expression in Human Monocytic Cells: Involvement of the SAPK/JNK and NF-κB Signaling Pathways.
Ahmad R, et al. Cell Physiol Biochem 2019. PMID 30964608 Free article.
BACKGROUND/AIMS: Increased circulatory levels of both TNF-α and CCL4/MIP-1β are found in metabolic diseases. However, it is unclear whether TNF-α which is a signature proinflammatory cytokine involved in metabolic inflammation, can induce/promote the expression of CCL4. ...RESULTS: TNF-α induces CCL4 expression at mRNA and protein levels, in both THP-1 monocytic cells and macrophages (P<0.05). TNF-α-driven CCL4 production was markedly abrogated by pre-treatment with anti-TNFR1/2 neutralizing antibodies. ...
BACKGROUND/AIMS: Increased circulatory levels of both TNF-α and CCL4/MIP-1β are found in metabolic diseases. However, it is unclear w …
Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems.
Kochumon S, et al. Cell Physiol Biochem 2018. PMID 29669317 Free article.
Since CCL4 (Chemokine (C-C motif) ligand 4), also known as macrophage inflammatory protein-1β (MIP-1β), plays an important role in the migration of monocytes into the adipose tissue, we investigated the expression of CCL4 in monocytic cells/macrophages following activation with free fatty acid palmitate. ...Inhibition of NF-kB and MAPK pathways suppressed the palmitate mediated induction of CCL4. Moreover, induction of CCL4 was blocked by PI3 Kinase inhibitors LY294002 and wortmannin. ...
Since CCL4 (Chemokine (C-C motif) ligand 4), also known as macrophage inflammatory protein-1β (MIP-1β), plays an important rol …
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