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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 5
1996 25
1997 31
1998 36
1999 54
2000 84
2001 65
2002 66
2003 65
2004 48
2005 61
2006 54
2007 65
2008 70
2009 68
2010 51
2011 59
2012 66
2013 75
2014 66
2015 69
2016 58
2017 49
2018 50
2019 16
2020 0
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1,230 results
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Page 1
Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor
Frampton D, et al. Cancer Cell 2018. PMID 29634949 Free PMC article.
We identified CCL5 as a possible driver of CTVT regression. Changes in gene expression are associated with methylation changes at specific intragenic sites. ...
We identified CCL5 as a possible driver of CTVT regression. Changes in gene expression are associated with methylation changes at spe …
Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle.
Ishiuchi Y, et al. Cytokine 2018. PMID 29558694
Although most myokine secretions were not affected by EPS, the secretion of Chemokine (C-C motif) ligand 5 (CCL5) (regulated on activation, normal T cell expressed and secreted (RANTES)) was significantly reduced by EPS. ...Finally, mouse experiments revealed that voluntary wheel-running exercise reduced serum CCL5 levels and Ccl5 gene expression in the fast-twitch muscles. ...
Although most myokine secretions were not affected by EPS, the secretion of Chemokine (C-C motif) ligand 5 (CCL5) (regulated o …
The Interaction of Heparin Tetrasaccharides with Chemokine CCL5 Is Modulated by Sulfation Pattern and pH.
Singh A, et al. J Biol Chem 2015. PMID 25907556 Free PMC article.
The interaction between CCL5 and its receptor on monocytes, CCR1, is mediated through residues Arg-17 and -47 in CCL5, which overlap with the GAG-binding (44)RKNR(47) "BBXB" motifs. ...Simulations of a 12-mer heparin fragment bound to CCL5 indicated that the oligosaccharide preferred to interact simultaneously with both (44)RKNR(47) motifs in the CCL5 homodimer and engaged residues Arg-47 and -17 from both chains. ...
The interaction between CCL5 and its receptor on monocytes, CCR1, is mediated through residues Arg-17 and -47 in CCL5, which o …
CCL5 derived from platelets increases megakaryocyte proplatelet formation.
Machlus KR, et al. Blood 2016. PMID 26647394 Free PMC article.
Platelets store inflammatory cytokines, including the chemokine ligand 5 (CCL5, RANTES); after TRAP activation, platelets release over 25 ng/mL CCL5. We hypothesized that CCL5 could regulate platelet production by binding to its receptor, CCR5, on MKs. Maraviroc (CCR5 antagonist) or CCL5 immunodepletion diminished 95% and 70% of the effect of platelet releasate, respectively, suggesting CCL5 derived from platelets is sufficient to drive increased platelet production through MK CCR5. ...
Platelets store inflammatory cytokines, including the chemokine ligand 5 (CCL5, RANTES); after TRAP activation, platelets rele …
Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension.
Mikolajczyk TP, et al. FASEB J 2016. PMID 26873938 Free PMC article.
In particular, the content of T lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, and CCR5 receptors for RANTES chemokine was increased by Ang II (CCR1, 15.6 ± 1.5% vs. 31 ± 5%; P < 0.01). ...Thus, chemokine RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation....
In particular, the content of T lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, and CCR5 receptors for RANTES chemokine
Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence Henoch-Schönlein purpura susceptibility and severity.
Yu HH, et al. J Formos Med Assoc 2015. PMID 25839768 Free article.
Our aim was to determine the serum levels of chemokines and investigate the association of chemokine gene polymorphisms with childhood HSP. ...RESULTS: Five serum chemokine levels were significantly elevated in patients with the acute stage of HSP compared to the normal controls (p < 0.05). ...
Our aim was to determine the serum levels of chemokines and investigate the association of chemokine gene polymorphisms with childhoo …
Human CCL5 trimer: expression, purification and initial crystallographic studies.
Chen YC, et al. Acta Crystallogr F Struct Biol Commun 2018. PMID 29400316 Free PMC article.
The chemokine CCL5 is considered to be a potential therapeutic target because of its ability to recruit immune cells to inflammatory sites. ...Here, a CCL5 mutant (CCL5-E66S) which is deficient in oligomer formation was mixed with native CCL5 to prepare a protein trimer. ...
The chemokine CCL5 is considered to be a potential therapeutic target because of its ability to recruit immune cells to inflam …
Association between CC motif chemokine ligand 5 (CCL5) polymorphisms and asthma risk: an updated meta-analysis.
Huang H, et al. J Investig Allergol Clin Immunol 2015. PMID 25898691 Free article.
BACKGROUND: Findings regarding the associations between the CC motif chemokine ligand 5 (CCL5) -403G/A and -28C/G polymorphisms and asthma risk are controversial.We performed a meta-analysis to determine whether CCL5 polymorphisms are associated with asthma risk. ...CONCLUSIONS: This meta-analysis suggests that the CCL5 -28C/G polymorphism is a risk factor for asthma....
BACKGROUND: Findings regarding the associations between the CC motif chemokine ligand 5 (CCL5) -403G/A and -28C/G polymorphism …
The chemokine CCL5 as a potential prognostic factor predicting disease progression in stage II breast cancer patients.
Yaal-Hahoshen N, et al. Clin Cancer Res 2006 - Review. PMID 16899591 Free article.
PURPOSE: The aim of this study was to determine the prognostic value of the chemokine CCL5, considered as a promalignancy factor in breast cancer, in predicting breast cancer progression and to evaluate its ability to strengthen the prognostic significance of other biomarkers. ...In the stage II group as a whole, the combinations of CCL5(-)/ER-alpha(+) and CCL5(-)/PR(+) were highly correlated with an improved prognosis. ...
PURPOSE: The aim of this study was to determine the prognostic value of the chemokine CCL5, considered as a promalignancy fact …
Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib.
Suenaga M, et al. Clin Colorectal Cancer 2018. PMID 29606345
BACKGROUND: The C-C motif chemokine ligand 5/C-C motif chemokine receptor 5 (CCL5/CCR5) pathway has been shown to induce endothelial progenitor cell migration, resulting in increased vascular endothelial growth factor A expression. We hypothesized that genetic polymorphisms in the CCL5/CCR5 pathway predict efficacy and toxicity in patients with metastatic colorectal cancer (mCRC) treated with regorafenib. ...
BACKGROUND: The C-C motif chemokine ligand 5/C-C motif chemokine receptor 5 (CCL5/CCR5) pathway has been shown to induc …
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