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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 3
1988 5
1989 11
1990 12
1991 14
1992 23
1993 48
1994 53
1995 73
1996 95
1997 124
1998 229
1999 262
2000 322
2001 384
2002 395
2003 435
2004 512
2005 629
2006 655
2007 480
2008 117
2009 107
2010 72
2011 90
2012 94
2013 83
2014 78
2015 77
2016 53
2017 56
2018 50
2019 31
2020 0
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5,323 results
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Page 1
CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer.
Cabrero-de Las Heras S and Martínez-Balibrea E. World J Gastroenterol 2018 - Review. PMID 30479461 Free PMC article.
The CXC family of chemokines (CXCL1 to 17) are small (8 to 10 kDa) secreted proteins that attract neutrophils and lymphocytes. These chemokines signal through chemokine receptors (CXCR) 1 to 8. Several studies have reported that these chemokines and receptors have a role in either the promotion or inhibition of cancer, depending on their capacity to suppress or stimulate the action of the immune system, respectively. ...
The CXC family of chemokines (CXCL1 to 17) are small (8 to 10 kDa) secreted proteins that attract neutrophils and lymphocytes. These …
The Role of CXC Chemokine Receptors 1-4 on Immune Cells in the Tumor Microenvironment
Susek KH, et al. Front Immunol 2018 - Review. PMID 30319622 Free PMC article.
Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. ...
Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokin
CXC chemokines and chemokine receptors in gastric cancer: from basic findings towards therapeutic targeting.
Lee HJ, et al. World J Gastroenterol 2014 - Review. PMID 24587647 Free PMC article.
There is also growing evidence to suggest that chemokines not only play a role in the immune system, but are also involved in the development and progression of tumors. In gastric cancer, CXC chemokines and chemokine receptors regulate the trafficking of cells in and out of the tumor microenvironment. ...
There is also growing evidence to suggest that chemokines not only play a role in the immune system, but are also involved in the dev …
CXCL9/CXCL10 angiostasis CXC-chemokines in parallel with the CXCL12 as an angiogenesis CXC-chemokine are variously expressed in pre-eclamptic-women and their neonates.
Darakhshan S, et al. Pregnancy Hypertens 2019. PMID 31487653
BACKGROUND: The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and chemokines are involved. ...The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these chemokines were investigated by ELISA and western blot analysis, respectively. ...
BACKGROUND: The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokine …
The role of CXC chemokines and their receptors in the progression and treatment of tumors.
Zhu Q, et al. J Mol Histol 2012 - Review. PMID 22752457
It appears, however, that the biological effects mediated by chemokines are far more complex, and virtually all cells, including many tumor cell types, can express chemokines and chemokine receptors. ...In this paper, CXC chemokines and their role in the progression and treatment of tumors will be reviewed....
It appears, however, that the biological effects mediated by chemokines are far more complex, and virtually all cells, including many …
CXC and CC chemokines as angiogenic modulators in nonhaematological tumors.
Santoni M, et al. Biomed Res Int 2014 - Review. PMID 24971349 Free PMC article.
Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. ...In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors....
Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angi
Identification of Potential Therapeutic Targets Among CXC Chemokines in Breast Tumor Microenvironment Using Integrative Bioinformatics Analysis.
Chen E, et al. Cell Physiol Biochem 2018. PMID 29495008 Free article.
The cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is modulated in part by chemokines. ...However, the differential expression profiles and prognostic values of these chemokines remains to be elucidated. METHODS: In this study, we compared transcriptional CXC chemokines and survival data of patients with breast carcinoma (BC) using the ONCOMINE dataset, Kaplan-Meier Plotter, TCGA and cBioPortal. ...
The cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is modulated in …
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets
Alenazi Y, et al. Sci Rep 2018. PMID 29679010 Free PMC article.
Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. ...P1243 binds 11 CC-chemokines with K(d) < 10 nM, and 10 CC-chemokines with K(d) between 10 and 100 nM. P1156 binds two ELR + CXC-chemokines with K(d) < 10 nM, and four ELR + CXC-chemokines with K(d) between 10 and 100 nM. ...
Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifical …
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