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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 5
1988 2
1989 5
1990 14
1991 44
1992 54
1993 67
1994 73
1995 73
1996 87
1997 94
1998 175
1999 198
2000 241
2001 265
2002 283
2003 310
2004 348
2005 373
2006 421
2007 423
2008 477
2009 538
2010 520
2011 522
2012 625
2013 587
2014 652
2015 682
2016 519
2017 549
2018 463
2019 213
2020 1
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8,811 results
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Page 1
Identification of Potential Therapeutic Targets Among CXC Chemokines in Breast Tumor Microenvironment Using Integrative Bioinformatics Analysis.
Chen E, et al. Cell Physiol Biochem 2018. PMID 29495008 Free article.
However, the differential expression profiles and prognostic values of these chemokines remains to be elucidated. METHODS: In this study, we compared transcriptional CXC chemokines and survival data of patients with breast carcinoma (BC) using the ONCOMINE dataset, Kaplan-Meier Plotter, TCGA and cBioPortal. ...CONCLUSIONS: Integrative bioinformatics analysis suggests that CXCL8/12/14 are potential suitable targets for precision therapy in BC patients compared to other CXC chemokines....
However, the differential expression profiles and prognostic values of these chemokines remains to be elucidated. METHODS: In this st …
A role for CXC chemokines and their receptors in stress axis regulation of common carp.
Pijanowski L, et al. Gen Comp Endocrinol 2019. PMID 31075272
In order to clarify a potential role for chemokines and their receptors in the stress response of fish, we studied changes in the expression patterns of CXC ligands and their receptors in the stress axis organs of carp, during a restraint stress procedure. ...Our results imply that in teleost fish, CXC chemokines and their receptors are involved in neuroendocrine regulation. The active regulation of their expression in stress axis organs during periods of restraint indicates a significant role in the stress response....
In order to clarify a potential role for chemokines and their receptors in the stress response of fish, we studied changes in the exp …
Cancer to bone: a fatal attraction
Weilbaecher KN, et al. Nat Rev Cancer 2011 - Review. PMID 21593787 Free PMC article.
Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS.
Huising MO, et al. Trends Immunol 2003. PMID 12810106
The mammalian CXC chemokine system comprises 16 ligands and six receptors, and its actions stretch well beyond the immune system. ...Comparison of the phylogenies of vertebrate CXC chemokines revealed that fish and mammals have found different solutions to similar problems, grafted on the same basic structural motif. ...
The mammalian CXC chemokine system comprises 16 ligands and six receptors, and its actions stretch well beyond the immune system. ... …
Sequence similarities of a subgroup of CXC chemokines related to murine LIX: implications for the interpretation of evolutionary relationships among chemokines.
Smith JB, et al. J Leukoc Biol 1997 - Review. PMID 9365114
The murine CXC chemokine LIX has distinctive sequence features that suggest it is a novel chemokine. Among known human chemokines, ENA-78 and GCP-2 are the two most closely related to LIX. ...These observations may have important implications for other chemokines that belong to clusters of closely related genes....
The murine CXC chemokine LIX has distinctive sequence features that suggest it is a novel chemokine. Among known human chemokines
Molecular cloning and biophysical characterization of CXCL3 chemokine
Gulati K, et al. Int J Biol Macromol 2018. PMID 28928065
CXCL3 is a neutrophil activating chemokine that belongs to GRO subfamily of CXC chemokines. GRO chemokine family comprises of three chemokines GRO α (CXCL1), GROβ (CXCL2), and GRO γ (CXCL3), which arose as a result of gene duplication events during the course of chemokine evolution. Although primary sequences of GRO chemokines are highly similar, they performs several protein specific functions in addition to their common property of neutrophil trafficking. ...
CXCL3 is a neutrophil activating chemokine that belongs to GRO subfamily of CXC chemokines. GRO chemokine family comprises of …
Cloning and bioactivity analysis of a CXC ligand in black seabream Acanthopagrus schlegeli: the evolutionary clues of ELR+CXC chemokines.
Zhonghua C, et al. BMC Immunol 2008. PMID 18990254 Free PMC article.
BACKGROUND: The ELR+CXC chemokines are multifunctional mediators that are mainly responsible for the recruitment of leucocytes to sites of inflammation and infection. ...The results revealed that BS CXC has a high gene similarity and tertiary structure similarity with piscine and mammalian CXC chemokines, both ELR-CXC and ELR+CXC, although it has a lower identity with ELR-CXC, compared with ELR+CXC chemokines. ...
BACKGROUND: The ELR+CXC chemokines are multifunctional mediators that are mainly responsible for the recruitment of leucocytes …
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4
Collins PJ, et al. FASEB J 2017. PMID 28360196 Free PMC article.
The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and hematopoiesis. ...
The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expres …
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