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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1976 1
1977 1
1982 3
1983 1
1986 3
1987 2
1988 3
1989 1
1990 3
1991 2
1992 2
1993 3
1994 2
1995 5
1996 7
1997 5
1998 1
1999 4
2000 3
2001 7
2002 17
2003 15
2004 13
2005 9
2006 15
2007 14
2008 24
2009 29
2010 32
2011 37
2012 42
2013 44
2014 32
2015 35
2016 47
2017 52
2018 51
2019 19
2020 1
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502 results
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Page 1
Interactions between the microbiota, immune and nervous systems in health and disease
Fung TC, et al. Nat Neurosci 2017 - Review. PMID 28092661 Free PMC article.
The diverse collection of microorganisms that inhabit the gastrointestinal tract, collectively called the gut microbiota, profoundly influences many aspects of host physiology, including nutrient metabolism, resistance to infection and immune system development. Studies investigating the gut-brain axis demonstrate a critical role for the gut microbiota in orchestrating brain development and behavior, and the immune system is emerging as an important regulator of these interactions. ...
The diverse collection of microorganisms that inhabit the gastrointestinal tract, collectively called the gut microbiota, profoundly influen …
Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders.
Bilbo SD, et al. Exp Neurol 2018 - Review. PMID 28698032 Free PMC article.
Immune molecules such as cytokines and chemokines and the cells that produce them within the brain, notably microglia, are critical for normal brain development. ...Patterson's work for the field of autism, with a focus on the impact that MIA by diverse environmental factors has on fetal brain development, immune system development, and the pathophysiology of ASD....
Immune molecules such as cytokines and chemokines and the cells that produce them within the brain, notably microglia, are critical for norm …
Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder
Vuong HE and Hsiao EY. Biol Psychiatry 2017 - Review. PMID 27773355 Free PMC article.
Links between particular bacteria from the indigenous gut microbiota and phenotypes relevant to ASD raise the important question of whether microbial dysbiosis plays a role in the development or presentation of ASD symptoms. ...
Links between particular bacteria from the indigenous gut microbiota and phenotypes relevant to ASD raise the important question of whether …
Complement System in Neural Synapse Elimination in Development and Disease.
Presumey J, et al. Adv Immunol 2017 - Review. PMID 28826529
Recent discoveries implicate the classical complement cascade in normal brain development and in disease. Complement proteins C1q, C3, and C4 participate in synapse elimination, tagging inappropriate synaptic connections between neurons for removal by phagocytic microglia that exist in a special, highly phagocytic state during the synaptic pruning period. ...Whether synapse loss in disease is a true reactivation of developmental synaptic pruning programs remains unclear; nonetheless, complement proteins represent potential therapeutic targets for both neurodevelopmental and neurodegenerative diseases....
Recent discoveries implicate the classical complement cascade in normal brain development and in disease. Complement proteins C1q, C3 …
Maternal immune activation: Implications for neuropsychiatric disorders
Estes ML and McAllister AK. Science 2016 - Review. PMID 27540164 Free PMC article.
Finally, the need for more research in this nascent field and the implications for identifying and developing new treatments for individuals at heightened risk for neuroimmune disorders are considered....
Finally, the need for more research in this nascent field and the implications for identifying and developing new treatments for indi …
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
Filipello F, et al. Immunity 2018. PMID 29752066 Free article.
Here, we show that TREM2 is essential for microglia-mediated synaptic refinement during the early stages of brain development. ...
Here, we show that TREM2 is essential for microglia-mediated synaptic refinement during the early stages of brain development. ...
Microbiome, Immunomodulation, and the Neuronal System
Marietta E, et al. Neurotherapeutics 2018 - Review. PMID 29313275 Free PMC article.
Significant roles of the intestinal bacteria are to stimulate the development of a competent mucosal immune system and to maintain tolerance within the intestine. ...
Significant roles of the intestinal bacteria are to stimulate the development of a competent mucosal immune system and to maintain to …
Maternal Immune Activation and Autism Spectrum Disorder: From Rodents to Nonhuman and Human Primates
Careaga M, et al. Biol Psychiatry 2017 - Review. PMID 28137374 Free PMC article.
A subset of women who are exposed to infection during pregnancy have an increased risk of giving birth to a child who will later be diagnosed with a neurodevelopmental or neuropsychiatric disorder. ...Maternal immune activation models in mice, rats, and nonhuman primates suggest that the maternal immune response is the critical link between exposure to infection during pregnancy and subsequent changes in brain and behavioral development of offspring. ...
A subset of women who are exposed to infection during pregnancy have an increased risk of giving birth to a child who will later be d …
The Role of the Immune System in Autism Spectrum Disorder
Meltzer A and Van de Water J. Neuropsychopharmacology 2017 - Review. PMID 27534269 Free PMC article.
During gestation, prenatal insults including maternal infection and subsequent immunological activation may increase the risk of autism in the child. Similarly, the presence of maternally derived anti-brain autoantibodies found in ~20% of mothers whose children are at risk for developing autism has defined an additional subphenotype of ASD. ...
During gestation, prenatal insults including maternal infection and subsequent immunological activation may increase the risk of autism in t …
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