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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 11
1994 20
1995 19
1996 20
1997 12
1998 20
1999 23
2000 37
2001 33
2002 38
2003 40
2004 31
2005 41
2006 44
2007 48
2008 62
2009 57
2010 43
2011 76
2012 96
2013 105
2014 99
2015 118
2016 126
2017 111
2018 135
2019 53
2020 1
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1,384 results
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Page 1
Molecular Pathogenesis of Cholangiocarcinoma.
Labib PL, et al. BMC Cancer 2019 - Review. PMID 30819129 Free PMC article.
This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarcinoma, with a focus on inflammation and cholestasis as the driving forces in cholangiocarcinoma development. RISK FACTORS FOR CHOLANGIOCARCINOGENESIS: Cholestatic liver diseases (e.g. primary sclerosing cholangitis and fibropolycystic liver diseases), liver cirrhosis, and biliary stone disease all increase the risk of cholangiocarcinoma. ...
This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarc
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Rizvi S and Gores GJ. Gastroenterology 2013 - Review. PMID 24140396 Free PMC article.
Cholangiocarcinomas (CCAs) are hepatobiliary cancers with features of cholangiocyte differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar CCA (pCCA), or distal CCA. These subtypes differ not only in their anatomic location, but in epidemiology, origin, etiology, pathogenesis, and treatment. ...
Cholangiocarcinomas (CCAs) are hepatobiliary cancers with features of cholangiocyte differentiation; they can be classified an
Animal models of cholangiocarcinoma.
Loeuillard E, et al. Biochim Biophys Acta Mol Basis Dis 2019 - Review. PMID 29627364 Free PMC article.
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with a poor overall prognosis. There is a critical need to develop effective targeted therapies for the treatment of this lethal disease. ...
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with a poor overall prognosis. There is a critical need to develop
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations
Wardell CP, et al. J Hepatol 2018. PMID 29360550 Free article.
The subtypes were 136 intrahepatic cholangiocarcinomas (ICCs), 101 distal cholangiocarcinomas (DCCs), 109 peri-hilar type cholangiocarcinomas (PHCs), and 66 gallbladder or cystic duct cancers (GBCs/CDCs). ...
The subtypes were 136 intrahepatic cholangiocarcinomas (ICCs), 101 distal cholangiocarcinomas (DCCs), 109 peri-hilar type c
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
Jusakul A, et al. Cancer Discov 2017. PMID 28667006 Free PMC article.
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. ...CCA molecular landscapes differ radically by etiology, underscoring how distinct cancer subtypes in the same organ may arise through different extrinsic and intrinsic carcinogenic processes. ...
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. ...
Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies
Fung BM, et al. World J Gastroenterol 2019 - Review. PMID 30783370 Free PMC article.
Importantly, PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma, hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. ...
Importantly, PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarc
Risk Factors for Cholangiocarcinoma in Thailand: A Systematic Review and Meta-Analysis.
Kamsa-ard S, et al. Asian Pac J Cancer Prev 2018 - Review. PMID 29579789 Free PMC article.
Background and objective: Cholangiocarcinoma remains a serious public health concern in Thailand. While many of the risk factors for cholangiocarcinoma in western countries are well-recognized, it remains unclear whether they are the same in Thailand. ...No association was found between cholangiocarcinoma and eating fermented fish (Pla-ra), northeastern Thai or Chinese sausage, sticky rice, meat, chewing betel nut, or eating fruit. ...
Background and objective: Cholangiocarcinoma remains a serious public health concern in Thailand. While many of the risk factors for …
Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma.
Nakaoka T, et al. Int J Mol Sci 2017 - Review. PMID 28545228 Free PMC article.
The effect of current chemotherapy regimens against cholangiocarcinoma is limited, and the prognosis of patients with cholangiocarcinoma is poor. ...Silencing of these tumor suppressor genes and miRNAs plays critical roles in the initiation and progression of cholangiocarcinoma. ...
The effect of current chemotherapy regimens against cholangiocarcinoma is limited, and the prognosis of patients with cholangiocar
Update on Pathogenesis of Opisthorchiasis and Cholangiocarcinoma.
Sripa B, et al. Adv Parasitol 2018 - Review. PMID 30442312
Infection with the food-borne liver fluke Opisthorchis viverrini causes cholangiocarcinoma (CCA). Whereas the cause of CCA in the West remains obscure, the principal risk factor in Thailand is opisthorchiasis. ...
Infection with the food-borne liver fluke Opisthorchis viverrini causes cholangiocarcinoma (CCA). Whereas the cause of CCA in the Wes …
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