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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 8
1990 3
1991 7
1992 13
1993 10
1994 13
1995 15
1996 15
1997 13
1998 13
1999 18
2000 16
2001 11
2002 16
2003 15
2004 11
2005 14
2006 13
2007 15
2008 18
2009 19
2010 22
2011 32
2012 34
2013 24
2014 13
2015 20
2016 23
2017 29
2018 28
2019 8
2020 0
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477 results
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Page 1
Drug-induced bile duct injury.
Visentin M, et al. Biochim Biophys Acta Mol Basis Dis 2018 - Review. PMID 28882625 Free article.
Among these, drug-induced bile duct injury is characterized by the destruction of the biliary epithelium following exposure to a drug. ...Such injury is often dose-dependent and thought to be the result of intrinsic drug toxicity. The histological changes resemble those seen in primary sclerosing cholangitis. ...
Among these, drug-induced bile duct injury is characterized by the destruction of the biliary epithelium following exposure to a d
Therapy of Primary Sclerosing Cholangitis--Today and Tomorrow.
Halilbasic E, et al. Dig Dis 2015 - Review. PMID 26641242
Primary sclerosing cholangitis (PSC) represents a fibro-obliterative bile duct disease with unpredictable individual clinical course that may progress to liver cirrhosis and malignancy. ...Ursodeoxycholic acid (UDCA) is the paradigm therapeutic bile acid and its role in medical therapy of PSC is still under debate. ...
Primary sclerosing cholangitis (PSC) represents a fibro-obliterative bile duct disease with unpredictable individual clinical …
Advances in IgG4-related pancreatobiliary diseases
Kamisawa T, et al. Lancet Gastroenterol Hepatol 2018 - Review. PMID 30047448
IgG4-related sclerosing cholangitis is a biliary counterpart that is typically associated with autoimmune pancreatitis. Two parallel immunological responses are thought to underlie the pathophysiology of these diseases: a pro-inflammatory, tissue-destructive process and an anti-inflammatory feedback response, which probably relates to IgG4 production. These diseases should be differentiated from conditions with a similar presentation (eg, pancreatobiliary malignancy, primary sclerosing cholangitis) by comparison of serum IgG4 concentration, imaging features, other organ involvement, histology, and steroid responsiveness. ...
IgG4-related sclerosing cholangitis is a biliary counterpart that is typically associated with autoimmune pancreatitis. Two pa …
Autoimmune sclerosing cholangitis: Evidence and open questions.
Terziroli Beretta-Piccoli B, et al. J Autoimmun 2018 - Review. PMID 30366655
Autoimmune sclerosing cholangitis (ASC) is a form of sclerosing cholangitis with strong autoimmune features overlapping with those of autoimmune hepatitis (AIH). It is a well-recognized nosological entity in paediatrics, where it accounts for the majority of sclerosing cholangitis cases. ...
Autoimmune sclerosing cholangitis (ASC) is a form of sclerosing cholangitis with strong autoimmune features over …
Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.
Guicciardi ME, et al. J Hepatol 2018. PMID 29802947 Free PMC article.
BACKGROUND & AIMS: Macrophages contribute to liver disease, but their role in cholestatic liver injury, including primary sclerosing cholangitis (PSC), is unclear. ...LAY SUMMARY: Primary sclerosing cholangitis (PSC) is an inflammatory liver disease which often progresses to liver failure. The cause of the disease is unclear and therapeutic options are limited. ...
BACKGROUND & AIMS: Macrophages contribute to liver disease, but their role in cholestatic liver injury, including primary sclerosing
IgG4-related sclerosing cholangitis: all we need to know.
Zen Y, et al. J Gastroenterol 2016 - Review. PMID 26817943
ISC needs to be discriminated from primary sclerosing cholangitis, cholangiocarcinoma, and other rare forms of lymphoplasmacytic cholangiopathy (e.g., follicular cholangitis and sclerosing cholangitis with granulocytic epithelial lesions). ...A better understanding of its immunopathology will offer some potential drug targets for this emerging biliary disease....
ISC needs to be discriminated from primary sclerosing cholangitis, cholangiocarcinoma, and other rare forms of lymphoplasmacyt …
Novel and emerging therapies for cholestatic liver diseases
Goldstein J and Levy C. Liver Int 2018 - Review. PMID 29758112
By altering or overwhelming these defence mechanisms, cholestatic diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) can further progress to biliary cirrhosis, end-stage liver disease and death or liver transplantation. While PBC is currently treated with ursodeoxycholic acid (UDCA) and obeticholic acid (OCA), many fail treatment, and we have yet to find an effective therapy for PSC. ...
By altering or overwhelming these defence mechanisms, cholestatic diseases such as primary biliary cholangitis (PBC) and primary s
IgG4-Related Sclerosing Cholangitis.
Nakazawa T, et al. Semin Liver Dis 2016 - Review. PMID 27466792
More men than women develop immunoglobulin G4-related sclerosing cholangitis (IgG4-SC). Age at clinical onset is significantly older in patients with IgG4-SC. Patients with IgG4-SC appear similar to those with cholangiocarcinoma and primary sclerosing cholangitis (PSC). The association between IgG4-SC and autoimmune pancreatitis (AIP) is useful for the diagnosis of IgG4-SC. ...
More men than women develop immunoglobulin G4-related sclerosing cholangitis (IgG4-SC). Age at clinical onset is significantly …
Pharmacologic management of primary sclerosing cholangitis: what's in the pipeline?
Suri J, et al. Expert Rev Gastroenterol Hepatol 2019 - Review. PMID 31257956
Introduction: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by biliary inflammation, fibrosis, and stricturing. Although considered progressive, its course is difficult to predict, and there is currently no definitive therapy shown to alter disease course and prevent death or the need for liver transplantation. ...
Introduction: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by biliary inflammation, …
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