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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 16
1946 57
1947 62
1948 102
1949 85
1950 142
1951 167
1952 234
1953 277
1954 266
1955 288
1956 289
1957 427
1958 433
1959 497
1960 506
1961 490
1962 628
1963 935
1964 1236
1965 949
1966 1067
1967 1304
1968 1581
1969 1604
1970 1629
1971 1847
1972 2073
1973 2083
1974 2113
1975 1900
1976 1809
1977 1837
1978 1692
1979 1778
1980 1969
1981 1842
1982 1932
1983 1809
1984 1831
1985 1759
1986 1716
1987 1640
1988 1829
1989 1874
1990 2151
1991 2248
1992 2188
1993 2058
1994 1974
1995 2147
1996 1956
1997 1988
1998 1896
1999 1871
2000 2187
2001 2403
2002 2375
2003 2481
2004 2598
2005 2678
2006 2749
2007 2902
2008 2752
2009 2983
2010 3034
2011 3001
2012 2862
2013 3049
2014 2994
2015 2960
2016 2868
2017 2836
2018 2576
2019 1174
2020 22
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118,653 results
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Page 1
Cholesterol-Recognition Motifs in Membrane Proteins.
Fantini J, et al. Adv Exp Med Biol 2019 - Review. PMID 31098808
There appear to be multiple mechanisms by which cholesterol interacts with proteins. A complete understanding of cholesterol-sensing motifs is still undergoing refinement. ...Our understanding of the factors that determine if these motifs are functional in cholesterol binding will allow us enhanced predictive capabilities....
There appear to be multiple mechanisms by which cholesterol interacts with proteins. A complete understanding of cholesterol-s …
Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer.
Lyu J, et al. Cells 2019 - Review. PMID 31035320 Free PMC article.
As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. This review discusses the role of cholesterol in angiogenesis, with a particular emphasis on cholesterol trafficking in endothelial cell signaling. ...
As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. Thi …
Cholesterol-embolization syndrome: current perspectives.
Ozkok A. Vasc Health Risk Manag 2019 - Review. PMID 31371977 Free PMC article.
Cholesterol-embolization syndrome (CES) is a multisystemic disease with various clinical manifestations. CES is caused by embolization of cholesterol crystals (CCs) from atherosclerotic plaques located in the major arteries, and is induced mostly iatrogenically by interventional and surgical procedures; however, it may also occur spontaneously. ...
Cholesterol-embolization syndrome (CES) is a multisystemic disease with various clinical manifestations. CES is caused by embolizatio
Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.
Chua NK, et al. J Biol Chem 2019. PMID 30940729 Free PMC article.
Squalene monooxygenase (SM) is a rate-limiting enzyme in cholesterol synthesis. The region comprising the first 100 amino acids, termed SM N100, represents the shortest cholesterol-responsive degron and enables SM to sense excess cholesterol in the endoplasmic reticulum (ER) membrane. ...However, the ubiquitination site required for cholesterol regulation of SM N100 is unknown. Here, we used SM N100 fused to GFP as a model degron to recapitulate cholesterol-mediated SM degradation and show that neither SM lysine residues nor the N terminus impart instability. ...
Squalene monooxygenase (SM) is a rate-limiting enzyme in cholesterol synthesis. The region comprising the first 100 amino acids, term …
Cholesterol Binding Sites in Inwardly Rectifying Potassium Channels.
Rosenhouse-Dantsker A. Adv Exp Med Biol 2019 - Review. PMID 31098814
In particular, in recent years, cholesterol has been shown to modulate a growing number of Kir channels. Subsequent to the discovery that members of the Kir2 subfamily were down-regulated by cholesterol, we have shown that members of several other Kir subfamilies were also modulated by cholesterol. ...Among these, Kir2.1 was down-regulated by cholesterol whereas Kir3.2^ and Kir3.4* were both up-regulated by cholesterol. Despite the opposite impact of cholesterol on these Kir3 channels compared to Kir2.1, putative cholesterol binding sites in all three channels were identified in equivalent transmembrane domains. ...
In particular, in recent years, cholesterol has been shown to modulate a growing number of Kir channels. Subsequent to the discovery …
Nuclear receptors, cholesterol homeostasis and the immune system.
Shahoei SH and Nelson ER. J Steroid Biochem Mol Biol 2019 - Review. PMID 31002862 Free PMC article.
Cholesterol is essential for maintaining membrane fluidity in eukaryotes. Additionally, the synthetic cascade of cholesterol results in precursor molecules important for cellular function such as lipid raft formation and protein prenylation. As such, cholesterol homeostasis is tightly regulated. Interestingly, it is now known that some cholesterol precursors and many metabolites serve as active signaling molecules, binding to different classes of receptors including the nuclear receptors. ...
Cholesterol is essential for maintaining membrane fluidity in eukaryotes. Additionally, the synthetic cascade of cholesterol r
Role of cholesterol homeostasis and its efflux pathways in cancer progression.
Sharma B and Agnihotri N. J Steroid Biochem Mol Biol 2019 - Review. PMID 31063804
Tumor cells show high avidity for cholesterol in order to support their inherent nature to divide and proliferate. This results in the rewiring of cholesterol homeostatic pathways by influencing not only de novo synthesis but also uptake or efflux pathways of cholesterol. Recent findings have pointed towards the importance of cholesterol efflux in tumor pathogenesis. Cholesterol efflux is the first and foremost step in reverse cholesterol transport and any perturbation in this pathway may lead to the accumulation of intracellular cholesterol, thereby altering the cellular equilibrium. ...
Tumor cells show high avidity for cholesterol in order to support their inherent nature to divide and proliferate. This results in th …
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype.
Cai D, et al. Nat Commun 2019. PMID 31604910 Free PMC article.
Genetic and pharmacological inhibition of RORγ reduces tumor cholesterol content and synthesis rate while preserving host cholesterol homeostasis. We demonstrate that RORγ functions as an essential activator of the entire cholesterol-biosynthesis program, dominating SREBP2 via its binding to cholesterol-biosynthesis genes and its facilitation of the recruitment of SREBP2. ...
Genetic and pharmacological inhibition of RORγ reduces tumor cholesterol content and synthesis rate while preserving host choleste
Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis
Chen N, et al. N Engl J Med 2019 - Clinical Trial. PMID 31340116
At week 27, the decrease in total cholesterol was greater with roxadustat than with epoetin alfa (difference, -22 mg per deciliter; 95% CI, -29 to -16), as was the decrease in low-density lipoprotein cholesterol (difference, -18 mg per deciliter; 95% CI, -23 to -13). ...
At week 27, the decrease in total cholesterol was greater with roxadustat than with epoetin alfa (difference, -22 mg per deciliter; 9 …
Modulation of Bone and Marrow Niche by Cholesterol.
Yin W, et al. Nutrients 2019 - Review. PMID 31234305 Free PMC article.
Correlation between circulating cholesterol and bone marrow adipocytes remains elusive, which seems opposite to its effects on osteoblasts. Epidemiological evidence has demonstrated that cholesterol deteriorates or benefits bone metabolism depending on the types, such as low-density lipoprotein (LDL) or high-density lipoprotein (HDL) cholesterol. ...
Correlation between circulating cholesterol and bone marrow adipocytes remains elusive, which seems opposite to its effects on osteob …
118,653 results
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