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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1957 1
1959 2
1963 1
1964 1
1980 1
1981 64
1982 144
1983 143
1984 184
1985 212
1986 223
1987 194
1988 259
1989 299
1990 367
1991 422
1992 432
1993 404
1994 434
1995 501
1996 458
1997 510
1998 536
1999 630
2000 721
2001 842
2002 937
2003 976
2004 1014
2005 1093
2006 1108
2007 1079
2008 1196
2009 1217
2010 1215
2011 1228
2012 1218
2013 1469
2014 1549
2015 1482
2016 1496
2017 1347
2018 1287
2019 548
2020 11
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26,985 results
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Page 1
Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol.
Ray KK, et al. N Engl J Med 2019 - Clinical Trial. PMID 30865796 Free article.
BACKGROUND: Short-term studies have shown that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low-density lipoprotein (LDL) cholesterol. ...The primary end point was safety, and the principal secondary end point (principal efficacy end point) was the percentage change in the LDL cholesterol level at week 12 of 52 weeks. ...
BACKGROUND: Short-term studies have shown that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low-density lipoprotein …
Non-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment.
Carr SS, et al. Pathology 2019 - Review. PMID 30595507
In routine clinical practice, the Friedewald equation is used to estimate LDL-cholesterol, but it has limitations. Commercially available direct measures of LDL-cholesterol are not standardised. ...Non-HDL-cholesterol and apoB are more accurate measures than LDL-cholesterol in hypertriglyceridaemic individuals, non-fasting samples, and in those with very-low LDL-cholesterol concentrations. ...
In routine clinical practice, the Friedewald equation is used to estimate LDL-cholesterol, but it has limitations. Commerciall …
A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke.
Amarenco P, et al. N Engl J Med 2020 - Clinical Trial. PMID 31738483
The target level for low-density lipoprotein (LDL) cholesterol to reduce cardiovascular events after stroke has not been well studied. ...The mean LDL cholesterol level at baseline was 135 mg per deciliter (3.5 mmol per liter), and the mean achieved LDL cholesterol level was 65 mg per deciliter (1.7 mmol per liter) in the lower-target group and 96 mg per deciliter (2.5 mmol per liter) in the higher-target group. ...
The target level for low-density lipoprotein (LDL) cholesterol to reduce cardiovascular events after stroke has not been well …
What is 'LDL cholesterol'?
Holmes MV and Ala-Korpela M. Nat Rev Cardiol 2019. PMID 30700860
Effects of PCSK9 inhibitors on LDL cholesterol, cardiovascular morbidity and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials.
Dicembrini I, et al. J Endocrinol Invest 2019. PMID 30762200
The present meta-analysis is aimed at the assessment of PCSK9 inhibitors effect on LDL Cholesterol, cardiovascular morbidity and all-cause mortality. ...CONCLUSIONS: PCSK-9 inhibitors are effective in reducing LDL cholesterol and the incidence of major cardiovascular events in high-risk patients. ...
The present meta-analysis is aimed at the assessment of PCSK9 inhibitors effect on LDL Cholesterol, cardiovascular morbidity a …
Pharmacological lipid-modification therapies for prevention of ischaemic heart disease: current and future options
Ray KK, et al. Lancet 2019 - Review. PMID 31448741 Free article.
Within the lipid profile, the principal target is lowering LDL cholesterol, firstly with lifestyle interventions and subsequently with pharmacological therapy. ...In addition to LDL cholesterol, mendelian randomisation studies support a causal role for lipoprotein(a) and triglycerides in ischaemic heart disease. ...
Within the lipid profile, the principal target is lowering LDL cholesterol, firstly with lifestyle interventions and subsequen …
Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol.
Vincent MJ, et al. Am J Clin Nutr 2019 - Review. PMID 30596814
BACKGROUND: Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Dietary guidance recommends reducing saturated fatty acid, trans fatty acid, and cholesterol intakes to reduce circulating LDL cholesterol. ...Mean predicted changes in LDL cholesterol for an increase of 100 mg dietary cholesterol/d were 1.90, 4.46, and 4.58 mg/dL for the linear, nonlinear MM, and Hill models, respectively. ...
BACKGROUND: Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Dietary guid …
Lipid-Lowering Agents
Hegele RA and Tsimikas S. Circ Res 2019. PMID 30702996
Much effort has been directed to agents that reduce LDL (low-density lipoprotein) cholesterol, triglyceride, and Lp[a] (lipoprotein[a]), with some sustained programs on agents to raise HDL (high-density lipoprotein) cholesterol. Lomitapide, mipomersen, AAV8.TBG.hLDLR, inclisiran, bempedoic acid, and gemcabene primarily target LDL cholesterol. Alipogene tiparvovec, pradigastat, and volanesorsen primarily target elevated triglycerides, whereas evinacumab and IONIS-ANGPTL3-L(Rx) target both LDL cholesterol and triglyceride. ...
Much effort has been directed to agents that reduce LDL (low-density lipoprotein) cholesterol, triglyceride, and Lp[a] (lipopr …
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.
Huang L, et al. Nature 2019. PMID 31019307 Free PMC article.
Atherosclerosis, which underlies life-threatening cardiovascular disorders such as myocardial infarction and stroke(1), is initiated by passage of low-density lipoprotein (LDLcholesterol into the artery wall and its engulfment by macrophages, which leads to foam cell formation and lesion development(2,3). ...DOCK4 promotes internalization of SR-B1 and transport of LDL by coupling the binding of LDL to SR-B1 with activation of RAC1. ...
Atherosclerosis, which underlies life-threatening cardiovascular disorders such as myocardial infarction and stroke(1), is initiated by pass …
LDL cholesterol relates to depression, its severity, and the prospective course.
Wagner CJ, et al. Prog Neuropsychopharmacol Biol Psychiatry 2019. PMID 30779936
In patients with a current MDE, higher HAMD scores correlated also with higher values of triglycerides (ρ = 0.213, P = 0.015), total cholesterol (ρ = 0.199, P = 0.023), LDL cholesterol (ρ = 0.224, P = 0.010), and LDL/HDL ratio (ρ = 0.196, P = 0.026). Moreover, higher total cholesterol (ρ = -0.233, P = 0.010), LDL cholesterol (ρ = -0.235, P = 0.010), and LDL/HDL ratio (ρ = -0.199, P = 0.029) were associated with a stronger decline in HAMD score between study inclusion and direct follow-up. ...
In patients with a current MDE, higher HAMD scores correlated also with higher values of triglycerides (ρ = 0.213, P = 0.015), total chol
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