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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 12
1985 20
1986 26
1987 29
1988 39
1989 43
1990 48
1991 72
1992 57
1993 44
1994 65
1995 72
1996 64
1997 99
1998 107
1999 111
2000 154
2001 142
2002 176
2003 161
2004 176
2005 250
2006 240
2007 228
2008 258
2009 274
2010 257
2011 271
2012 306
2013 338
2014 385
2015 371
2016 342
2017 362
2018 376
2019 136
2020 3
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5,561 results
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Page 1
Can LDL cholesterol be too low? Possible risks of extremely low levels.
Olsson AG, et al. J Intern Med 2017 - Review. PMID 28295777 Free article.
Following the continuous accumulation of evidence supporting the beneficial role of reducing low-density lipoprotein cholesterol (LDL-C) levels in the treatment and prevention of atherosclerotic cardiovascular disease and its complications, therapeutic possibilities now exist to lower LDL-C to very low levels, similar to or even lower than those seen in newborns and nonhuman species. ...Even at extremely low LDL-C levels, critical capacities of steroid hormone and bile acid production are preserved, and the presence of a cholesterol blood-brain barrier protects cells in the central nervous system. ...
Following the continuous accumulation of evidence supporting the beneficial role of reducing low-density lipoprotein cholesterol ( …
LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature.
Ravnskov U, et al. Expert Rev Clin Pharmacol 2018 - Review. PMID 30198808
For half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been considered to be the major cause of atherosclerosis and cardiovascular disease (CVD), and statin treatment has been widely promoted for cardiovascular prevention. ...This article delineates the serious errors in these three reviews as well as other obvious falsifications of the cholesterol hypothesis. ...
For half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been cons …
[LDL-cholesterol and cardiovascular events: the lower the better?].
Weitgasser R, et al. Wien Med Wochenschr 2018 - Review. PMID 27770320 German.
For over 30 years, intensive research efforts investigated the role of LDL cholesterol in the pathogenesis of cardiovascular disease. In various settings, large statin trials showed an association between LDL cholesterol levels and cardiovascular event rates. ...
For over 30 years, intensive research efforts investigated the role of LDL cholesterol in the pathogenesis of cardiovascular d …
Long-term moderately elevated LDL-cholesterol and blood pressure and risk of coronary heart disease.
Ueda P, et al. PLoS One 2018. PMID 30059527 Free PMC article.
BACKGROUND: Harmful effects of long-term exposure to moderately elevated low-density lipoprotein (LDL)-cholesterol and blood pressure on coronary heart disease (CHD) have not been rigorously examined. ...The results for blood pressure were similar. CONCLUSIONS: Long-term exposure to moderate levels of LDL-cholesterol and blood pressure had a similar impact on CHD risk as shorter exposures to levels considered 'high' per clinical guidelines....
BACKGROUND: Harmful effects of long-term exposure to moderately elevated low-density lipoprotein (LDL)-cholesterol and bloo
Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors.
Fernández-Friera L, et al. J Am Coll Cardiol 2017. PMID 29241485 Free article.
CVRF freedom was defined as no current smoking and untreated blood pressure <140/90 mm Hg, fasting glucose <126 mg/dl, total cholesterol <240 mg/dl, low-density lipoprotein cholesterol (LDL-C) <160 mg/dl, and high-density lipoprotein cholesterol ≥40 mg/dl. A subgroup with optimal CVRFs (n = 740) was also defined as having blood pressure <120/80 mm Hg, fasting glucose <100 mg/dl, glycosylated hemoglobin <5.7%, and total cholesterol <200 mg/dl. ...
CVRF freedom was defined as no current smoking and untreated blood pressure <140/90 mm Hg, fasting glucose <126 mg/dl, total …
What is 'LDL cholesterol'?
Holmes MV and Ala-Korpela M. Nat Rev Cardiol 2019. PMID 30700860
Intensive LDL-cholesterol lowering therapy and neurocognitive function.
Banach M, et al. Pharmacol Ther 2017 - Review. PMID 27865998
The key lipid-lowering target is to achieve guideline-recommended low-density lipoprotein cholesterol (LDL-C) levels, usually by using statins. ...Gender, genetic, LDL-C-related genotypes and aging-related changes should also be considered. Some data indicate that carriers of apolipoprotein E (apoE) ε-4 allele, with low levels of apoA1 and high-density lipoprotein cholesterol have a distinct plasma lipid profile and may be more susceptible to neurocognitive dysfunction. ...
The key lipid-lowering target is to achieve guideline-recommended low-density lipoprotein cholesterol (LDL-C) levels, usually …
Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials.
Cholesterol Treatment Trialists' (CTT) Collaboration , et al. Lancet 2015. PMID 25579834
Effects on major vascular events, major coronary events, stroke, coronary revascularisation and mortality were weighted per 1.0 mmol/L reduction in LDL cholesterol and effects in men and women compared with a Cox model that adjusted for non-sex differences. ...Allocation to a statin had similar absolute effects on 1 year lipid concentrations in both men and women (LDL cholesterol reduced by about 1.1 mmol/L in statin vs control trials and roughly 0.5 mmol/L for more-intensive vs less-intensive therapy). ...
Effects on major vascular events, major coronary events, stroke, coronary revascularisation and mortality were weighted per 1.0 mmol/L reduc …
LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors.
Christensen JJ, et al. J Clin Lipidol 2016. PMID 27919354
However, elevated maternal LDL cholesterol (LDL-C) in pregnancy and offspring cardiovascular disease (CVD) risk has scarcely been studied. ...METHODS: We recruited 6-to-13-year-old children whose mothers attended a pregnancy cohort and who had high or low cholesterol in pregnancy, defined as LDL-C over the 90th percentile or below the 10th percentile within the pregnancy cohort, respectively. ...
However, elevated maternal LDL cholesterol (LDL-C) in pregnancy and offspring cardiovascular disease (CVD) risk has sca …
Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases
Ivanova EA, et al. Oxid Med Cell Longev 2017 - Review. PMID 28572872 Free PMC article.
It has been well documented that sdLDL has a greater atherogenic potential than that of other LDL subfractions and that sdLDL cholesterol (sdLDL-C) proportion is a better marker for prediction of cardiovascular disease than that of total LDL-C. Circulating sdLDL readily undergoes multiple atherogenic modifications in blood plasma, such as desialylation, glycation, and oxidation, that further increase its atherogenicity. ...
It has been well documented that sdLDL has a greater atherogenic potential than that of other LDL subfractions and that sdLDL chol
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