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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 3
1984 81
1985 185
1986 187
1987 167
1988 240
1989 256
1990 318
1991 370
1992 393
1993 369
1994 389
1995 452
1996 416
1997 459
1998 498
1999 543
2000 644
2001 747
2002 805
2003 825
2004 844
2005 924
2006 966
2007 922
2008 1012
2009 1034
2010 1033
2011 1052
2012 1055
2013 1293
2014 1342
2015 1294
2016 1196
2017 1073
2018 1017
2019 418
2020 5
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22,710 results
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Page 1
[LDL-cholesterol and cardiovascular events: the lower the better?].
Weitgasser R, et al. Wien Med Wochenschr 2018 - Review. PMID 27770320 German.
For over 30 years, intensive research efforts investigated the role of LDL cholesterol in the pathogenesis of cardiovascular disease. In various settings, large statin trials showed an association between LDL cholesterol levels and cardiovascular event rates. ...
For over 30 years, intensive research efforts investigated the role of LDL cholesterol in the pathogenesis of cardiovascular d …
Quantifying Atherogenic Lipoproteins: Current and Future Challenges in the Era of Personalized Medicine and Very Low Concentrations of LDL Cholesterol. A Consensus Statement from EAS and EFLM.
Langlois MR, et al. Clin Chem 2018. PMID 29760220 Free article.
CONTENT: We critically examined LDL cholesterol, non-HDL cholesterol, apolipoprotein B (apoB), and LDL particle number assays based on key criteria for medical application of biomarkers. (a) Analytical performance: Discordant LDL cholesterol quantification occurs when LDL cholesterol is measured or calculated with different assays, especially in patients with hypertriglyceridemia >175 mg/dL (2 mmol/L) and low LDL cholesterol concentrations <70 mg/dL (1.8 mmol/L). ...
CONTENT: We critically examined LDL cholesterol, non-HDL cholesterol, apolipoprotein B (apoB), and LDL particle …
Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases
Ivanova EA, et al. Oxid Med Cell Longev 2017 - Review. PMID 28572872 Free PMC article.
It has been well documented that sdLDL has a greater atherogenic potential than that of other LDL subfractions and that sdLDL cholesterol (sdLDL-C) proportion is a better marker for prediction of cardiovascular disease than that of total LDL-C. Circulating sdLDL readily undergoes multiple atherogenic modifications in blood plasma, such as desialylation, glycation, and oxidation, that further increase its atherogenicity. ...
It has been well documented that sdLDL has a greater atherogenic potential than that of other LDL subfractions and that sdLDL chol
Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review.
Ravnskov U, et al. BMJ Open 2016 - Review. PMID 27292972 Free PMC article.
CONCLUSIONS: High LDL-C is inversely associated with mortality in most people over 60 years. This finding is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly LDL-C, is inherently atherogenic). Since elderly people with high LDL-C live as long or longer than those with low LDL-C, our analysis provides reason to question the validity of the cholesterol hypothesis. ...
CONCLUSIONS: High LDL-C is inversely associated with mortality in most people over 60 years. This finding is inconsistent with the …
LDL cholesterol level in fifth-grade schoolchildren associates with stature.
Pyles LA, et al. J Lipid Res 2017. PMID 28870972 Free PMC article.
Short stature is associated with increased LDL-cholesterol levels and coronary artery disease in adults. We investigated the relationship of stature to LDL levels in children in the West Virginia Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project to determine whether the genetically determined inverse relationship observed in adults would be evident in fifth graders. ...The first (shortest) quartile showed an LDL level of 93.6 mg/dl compared with an LDL level of 89.7 mg/dl for the fourth (tallest) quartile. ...
Short stature is associated with increased LDL-cholesterol levels and coronary artery disease in adults. We investigated the r …
[Lowering LDL-cholesterol: the lower the better?].
Bots ML. Ned Tijdschr Geneeskd 2017. PMID 28145216 Dutch.
The issue is whether those with an achieved low LDL level (< 1.8 mmol/l) carry a lower vascular risk than those with an LDL between 1.8 and 2.5 mmol/l. ...One paper (shows no benefit for a LDL level lower than 2.5 mmol/l) is based on individual participant information, allowing for optimal adjustment. ...
The issue is whether those with an achieved low LDL level (< 1.8 mmol/l) carry a lower vascular risk than those with an LDL
Reducing elevated plasma LDL cholesterol: the central role of the LDL receptor.
Vincent J. Clin Pharmacol Ther 2014. PMID 24942393
Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for cardiovascular disease (CVD), and reduction of elevated LDL-C reduces mortality in patients at risk. This benefit has evolved from the use of statins and knowledge of the LDL receptor (LDLR). The most potent drugs used for dyslipidemias act by mechanisms that involve this receptor. ...
Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for cardiovascular disease (CVD), and reduc …
[Comparison of calculated LDL cholesterol (LDL-C) versus measured LDL cholesterol (LDL-M) and potential impact in terms of therapeutic management].
Reignier A, et al. Ann Biol Clin (Paris) 2014. PMID 25336132 French. Free article.
In this respect, the recommendations have been established based on target to achieve LDL-cholesterol. Currently in France, the determination of LDL-cholesterol is mainly carried out by the Friedewald formula whose limits are well known. ...On the other hand in 17% of cases the classification of subjects will be different, with a majority so overestimation of calculated LDL-cholesterol with respect to measured LDL-cholesterol. ...
In this respect, the recommendations have been established based on target to achieve LDL-cholesterol. Currently in France, th …
LDL cholesterol: should guidelines include targets?
Banerjee S, et al. Expert Rev Cardiovasc Ther 2014. PMID 24502625
Elevated low-density lipoprotein cholesterol (LDL-C) is associated with adverse cardiovascular outcomes. The strategy of target-based LDL-C lowering to reduce the risk of coronary heart disease and secondary event rates is now well established. However, the strategy for treating to a target LDL-C, and whether there is a lower threshold level for LDL-C continues to be debated. ...
Elevated low-density lipoprotein cholesterol (LDL-C) is associated with adverse cardiovascular outcomes. The strategy of targe …
Mobile phone-based interventions for improving adherence to medication prescribed for the primary prevention of cardiovascular disease in adults
Palmer MJ, et al. Cochrane Database Syst Rev 2018 - Review. PMID 29932455 Free PMC article.
The interventions received varied widely; one trial evaluated an intervention focused on blood pressure medication adherence delivered solely through short messaging service (SMS), and one intervention involved blood pressure monitoring combined with feedback delivered via smartphone. ...Due to heterogeneity in the nature and delivery of the interventions, we did not conduct a meta-analysis, and therefore reported results narratively.We judged the body of evidence for the effect of mobile phone-based interventions on objective outcomes (blood pressure and cholesterol) of low quality due to all included trials being at high risk of bias, and inconsistency in outcome effects. ...
The interventions received varied widely; one trial evaluated an intervention focused on blood pressure medication adherence delivere …
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