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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 3
1946 9
1947 2
1948 12
1949 8
1950 2
1951 42
1952 153
1953 184
1954 170
1955 196
1956 217
1957 320
1958 368
1959 388
1960 404
1961 389
1962 417
1963 538
1964 722
1965 443
1966 415
1967 760
1968 1206
1969 1170
1970 1221
1971 1350
1972 1559
1973 1602
1974 1634
1975 1520
1976 1479
1977 1576
1978 1430
1979 1516
1980 1700
1981 1618
1982 1688
1983 1606
1984 1730
1985 1807
1986 1735
1987 1666
1988 1824
1989 1912
1990 2231
1991 2325
1992 2351
1993 2213
1994 2163
1995 2387
1996 2163
1997 2327
1998 2235
1999 2319
2000 2695
2001 2956
2002 3014
2003 3169
2004 3312
2005 3556
2006 3611
2007 3641
2008 3806
2009 4067
2010 4125
2011 4068
2012 3979
2013 4447
2014 4438
2015 4241
2016 4027
2017 3946
2018 3501
2019 1537
2020 29
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127,507 results
Results by year
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Page 1
Brain cholesterol metabolism and Parkinson's disease.
Huang X, et al. Mov Disord 2019. PMID 30681742 Free PMC article.
Fasting plasma (S)24-OH-cholesterol (brain-derived cholesterol metabolite) and 27-OH-cholesterol (peripheral cholesterol metabolite) were quantified. ...Furthermore, (S)24-OH-cholesterol levels were stable over time, whereas 27-OH-cholesterol decreased with time in both cases and controls. ...
Fasting plasma (S)24-OH-cholesterol (brain-derived cholesterol metabolite) and 27-OH-cholesterol (peripheral cholest
The Interplay Between Cholesterol Metabolism and Intrinsic Ageing.
Mc Auley MT. Subcell Biochem 2018 - Review. PMID 30779007
A worthwhile way to examine how ageing intersects with CVD is to consider the effects ageing has on cholesterol metabolism, because dysregualted cholesterol metabolism is the key factor which underpins the pathology of CVD. The aim of this chapter is to outline a hypothesis which accounts for how ageing intersects with intracellular cholesterol metabolism. ...
A worthwhile way to examine how ageing intersects with CVD is to consider the effects ageing has on cholesterol metabolism, because d …
The Role of Cholesterol in Cancer.
Kuzu OF, et al. Cancer Res 2016 - Review. PMID 27197250 Free PMC article.
The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. ...Finally, preclinical studies tend to more consistently support the role of cholesterol in cancer, with several demonstrating that cholesterol homeostasis genes can modulate development. ...
The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis i …
Cholesterol Biosynthesis: A Mechanistic Overview.
Cerqueira NM, et al. Biochemistry 2016 - Review. PMID 27604037
In light of the current need for new drugs capable of controlling the levels of cholesterol in the bloodstream, it is important to understand how cholesterol is synthesized in the organism and identify the main enzymes involved in this process. ...We believe that this review may contribute to a deeper level of understanding of cholesterol metabolism and that it will serve as a useful resource for future studies of the cholesterol biosynthesis pathway....
In light of the current need for new drugs capable of controlling the levels of cholesterol in the bloodstream, it is important to un …
[Cholesterol metabolism].
Weis HJ. Klin Wochenschr 1970 - Review. PMID 4920502 German.
Determinants of cholesterol efflux capacity in humans.
Talbot CPJ, et al. Prog Lipid Res 2018 - Review. PMID 29269048
High-density lipoproteins (HDL) play an important role in the reverse cholesterol transport (RCT) pathway, contributing to the efflux of excess cellular cholesterol. ...It is therefore essential not only to understand targets to increase cholesterol efflux capacity, but also to prove causality between cholesterol efflux capacity and the prevention of CVD risk....
High-density lipoproteins (HDL) play an important role in the reverse cholesterol transport (RCT) pathway, contributing to the efflux …
Cholesterol metabolism in man.
Grundy SM. West J Med 1978 - Review. PMID 204111 Free PMC article.
Recent investigations on cholesterol metabolism in man have led to new insights into diseases associated with abnormal accumulations of cholesterol in plasma (hypercholesterolemia), arterial tissues (atherosclerosis) and biliary tract (gallstones). Regulation of cholesterol synthesis under the influence of dietary and plasma cholesterol, may play a crucial role in determining biliary and tissue concentrations of this sterol. ...
Recent investigations on cholesterol metabolism in man have led to new insights into diseases associated with abnormal accumulations …
Cholesterol metabolism and aging.
Kreisberg RA and Kasim S. Am J Med 1987 - Review. PMID 3544833
The low-density lipoprotein cholesterol concentration increases progressively in men and women after age 20, but more rapidly in men, accounting for most of the overall gender difference in total cholesterol. ...The high-density lipoprotein cholesterol concentrations remain constant in women throughout their lifetime. Beyond 30 years of age, women taking estrogen preparations have higher high-density lipoprotein cholesterol concentrations than women who are not taking estrogens. ...
The low-density lipoprotein cholesterol concentration increases progressively in men and women after age 20, but more rapidly in men, …
The effect of taurine on cholesterol metabolism.
Chen W, et al. Mol Nutr Food Res 2012 - Review. PMID 22648615
The elevated plasma cholesterol level, in particular, LDL cholesterol is regarded as an important risk factor for the development of atherosclerosis and coronary artery disease. A number of studies provide the evidence that taurine has the efficient action to reduce plasma and liver cholesterol concentrations, especially to decrease VLDL and LDL cholesterol in hypercholesterolemia animal induced by high cholesterol diet. ...
The elevated plasma cholesterol level, in particular, LDL cholesterol is regarded as an important risk factor for the developm …
A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation.
Mc Auley MT, et al. BMC Syst Biol 2012. PMID 23046614 Free PMC article.
In fact elevated plasma cholesterol, particularly Low Density Lipoprotein Cholesterol (LDL-C) has consistently stood out as a risk factor for having a cardiovascular event. ...This first whole-body systems based model of cholesterol balance could potentially be used as a tool to further improve our understanding of whole-body cholesterol metabolism and its dysregulation with age. ...
In fact elevated plasma cholesterol, particularly Low Density Lipoprotein Cholesterol (LDL-C) has consistently stood out as a …
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