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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1947 6
1948 7
1949 4
1950 13
1951 11
1952 10
1953 18
1954 14
1955 13
1956 13
1957 14
1958 14
1959 9
1960 24
1961 27
1962 26
1963 35
1964 34
1965 14
1981 1
1989 1
1991 1
1993 4
1994 42
1995 95
1996 102
1997 98
1998 97
1999 97
2000 95
2001 90
2002 75
2003 64
2004 71
2005 61
2006 89
2007 100
2008 100
2009 106
2010 99
2011 87
2012 83
2013 81
2014 67
2015 104
2016 102
2017 93
2018 105
2019 38
2020 0
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2,385 results
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Page 1
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.
Hampel H, et al. Brain 2018 - Review. PMID 29850777 Free PMC article.
The cholinergic hypothesis of Alzheimer's disease centres on the progressive loss of limbic and neocortical cholinergic innervation. Neurofibrillary degeneration in the basal forebrain is believed to be the primary cause for the dysfunction and death of forebrain cholinergic neurons, giving rise to a widespread presynaptic cholinergic denervation. ...
The cholinergic hypothesis of Alzheimer's disease centres on the progressive loss of limbic and neocortical cholinergic innerv …
Alzheimer's disease: Targeting the Cholinergic System.
Ferreira-Vieira TH, et al. Curr Neuropharmacol 2016 - Review. PMID 26813123 Free PMC article.
Nevertheless, synaptic loss is the principal correlate of disease progression and loss of cholinergic neurons contributes to memory and attention deficits. Thus, drugs that act on the cholinergic system represent a promising option to treat AD patients....
Nevertheless, synaptic loss is the principal correlate of disease progression and loss of cholinergic neurons contributes to memory a …
Cholinergic modulation of the immune system presents new approaches for treating inflammation.
Hoover DB. Pharmacol Ther 2017 - Review. PMID 28529069 Free PMC article.
Further investigation made the important discovery that cholinergic T cells within the spleen and not cholinergic nerve cells were the source of ACh that stimulated α7 receptors on splenic macrophages. ...This basic work has already fostered several clinical trials examining the efficacy of VNS and cholinergic therapeutics in human inflammatory diseases. ...
Further investigation made the important discovery that cholinergic T cells within the spleen and not cholinergic nerve cells …
Molecular, Cellular and Circuit Basis of Cholinergic Modulation of Pain.
Naser PV and Kuner R. Neuroscience 2018 - Review. PMID 28890048 Free PMC article.
We discuss the distribution of cholinergic neurons, muscarinic and nicotinic receptors over the central nervous system and the synaptic and circuit-level modulation by cholinergic signaling. ...Finally, we critically discuss the clinical relevance of cholinergic signaling to pain therapy. Cholinergic mechanisms contribute to several both conventional as well as unorthodox forms of pain treatments, and reciprocal interactions between cholinergic and opioidergic modulation impact on the function and efficacy of both opioids and cholinomimetic drugs....
We discuss the distribution of cholinergic neurons, muscarinic and nicotinic receptors over the central nervous system and the synapt …
Paediatric Tracheomalacia
Hysinger EB and Panitch HB. Paediatr Respir Rev 2016 - Review. PMID 25962857
Current treatment strategies involve pharmacotherapy with cholinergic agents, positive pressure ventilation, and surgical repair....
Current treatment strategies involve pharmacotherapy with cholinergic agents, positive pressure ventilation, and surgical repair....
The Input-Output Relationship of the Cholinergic Basal Forebrain.
Gielow MR and Zaborszky L. Cell Rep 2017. PMID 28199851 Free PMC article.
Here, we identify input neurons to cholinergic cells projecting to specific cortical regions by infecting cholinergic axon terminals with a monosynaptically restricted viral tracer. This approach revealed several circuit motifs, such as central amygdala neurons synapsing onto basolateral amygdala-projecting cholinergic neurons or strong somatosensory cortical input to motor cortex-projecting cholinergic neurons. ...
Here, we identify input neurons to cholinergic cells projecting to specific cortical regions by infecting cholinergic axon ter …
Cholinergic modulation of spatial learning, memory and navigation.
Solari N and Hangya B. Eur J Neurosci 2018 - Review. PMID 30055067 Free PMC article.
Since the hippocampus receives its main subcortical input from the medial septum of the basal forebrain (BF) cholinergic system, it is not surprising that the potential role of the septo-hippocampal pathway in spatial navigation has been investigated in many studies. ...Here we review the current state of the art of the division of labour within this complex 'navigation system', with special focus on how subcortical cholinergic inputs may regulate various aspects of spatial learning, memory and navigation....
Since the hippocampus receives its main subcortical input from the medial septum of the basal forebrain (BF) cholinergic system, it i …
Cholinergic modulation of the hippocampal region and memory function.
Haam J and Yakel JL. J Neurochem 2017 - Review. PMID 28791706 Free PMC article.
Cholinergic neurons densely innervate the hippocampus, mediating the formation of episodic as well as semantic memory. Here, we will review recent findings on acetylcholine's modulation of memory function, with a particular focus on hippocampus-dependent learning, and the circuits involved. ...This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms....
Cholinergic neurons densely innervate the hippocampus, mediating the formation of episodic as well as semantic memory. Here, we will
Cholinergic medication for antipsychotic-induced tardive dyskinesia.
Tammenmaa-Aho I, et al. Cochrane Database Syst Rev 2018 - Review. PMID 29553158 Free PMC article.
It has been proposed that TD could have a component of central cholinergic deficiency. Cholinergic drugs have been used to treat TD. ...The clinical effects of both older cholinergic drugs and new cholinergic agents, now used for treating Alzheimer's disease, are unclear, as too few, too small studies leave many questions unanswered. ...
It has been proposed that TD could have a component of central cholinergic deficiency. Cholinergic drugs have been used to tre …
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Lozovaya N, et al. Nat Commun 2018. PMID 29651049 Free PMC article.
We report that half striatal cholinergic interneurons are dual transmitter cholinergic and GABAergic interneurons (CGINs) expressing ChAT, GAD65, Lhx7, and Lhx6 mRNAs, labeled with GAD and VGAT, generating monosynaptic dual cholinergic/GABAergic currents and an inhibitory pause response. ...Therefore, most of the striatal cholinergic excitatory drive is balanced by a concomitant powerful GABAergic inhibition that is impaired by dopamine deprivation. ...
We report that half striatal cholinergic interneurons are dual transmitter cholinergic and GABAergic interneurons (CGINs) expr …
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