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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 3
2011 59
2012 131
2013 124
2014 136
2015 151
2016 168
2017 154
2018 196
2019 54
2020 0
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995 results
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Cognitive and emotional control of pain and its disruption in chronic pain.
Bushnell MC, et al. Nat Rev Neurosci 2013 - Review. PMID 23719569 Free PMC article.
Chronic pain is one of the most prevalent health problems in our modern world, with millions of people debilitated by conditions such as back pain, headache and arthritis. ...It will also examine the accumulating evidence that chronic pain itself alters brain circuitry, including that involved in endogenous pain control, suggesting that controlling pain becomes increasingly difficult as pain becomes chronic....
Chronic pain is one of the most prevalent health problems in our modern world, with millions of people debilitated by conditio
Central sensitization in chronic low back pain: A narrative review.
Sanzarello I, et al. J Back Musculoskelet Rehabil 2016 - Review. PMID 27062464
Central sensitization has been recently recognized as a potential pathophysiological mechanism underlying a group of chronic pain conditions, and may be a contributory factor for a sub-group of patients with chronic low back pain. ...First, to describe central sensitization and its symptoms and signs in patients with chronic pain disorders in order to allow its recognition in patients with nonspecific low back pain. ...
Central sensitization has been recently recognized as a potential pathophysiological mechanism underlying a group of chronic pain
The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain.
Edwards RR, et al. J Pain 2016 - Review. PMID 27586832 Free PMC article.
Collectively, the complexity and profound variability in chronic pain highlights the need to better understand the multidimensional array of interacting forces that determine the trajectory of chronic pain conditions. PERSPECTIVE: The AAPT is an evidence-based chronic pain classification system in which psychosocial concepts and processes are essential in understanding the development of chronic pain and its effects. ...
Collectively, the complexity and profound variability in chronic pain highlights the need to better understand the multidimens …
Pain Modulation and the Transition from Acute to Chronic Pain.
Heinricher MM. Adv Exp Med Biol 2016 - Review. PMID 26900066
There is now increasing evidence that pathological pain states are at least in part driven by changes in the brain itself. Descending modulatory pathways are known to mediate top-down regulation of nociceptive processing, transmitting cortical and limbic influences to the dorsal horn. ...Models of persistent pain that fail to include descending modulatory pathways are thus incomplete. Although teasing out individual links in a recurrent network is never straightforward, it is imperative that understanding of pain modulation be fully integrated into how we think about pain....
There is now increasing evidence that pathological pain states are at least in part driven by changes in the brain itself. Descending …
Neurobiology of fibromyalgia and chronic widespread pain.
Sluka KA and Clauw DJ. Neuroscience 2016 - Review. PMID 27291641 Free PMC article.
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. ...
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. …
Neural Circuits of Chronic Pain.
Kuner R and Flor H. Neuroscience 2018. PMID 30220381
Chronic pain: a review of its epidemiology and associated factors in population-based studies.
Mills SEE, et al. Br J Anaesth 2019 - Review. PMID 31079836 Free PMC article.
Chronic pain is a common, complex, and distressing problem that has a profound impact on individuals and society. It frequently presents as a result of a disease or an injury; however, it is not merely an accompanying symptom, but rather a separate condition in its own right, with its own medical definition and taxonomy. Studying the distribution and determinants of chronic pain allows us to understand and manage the problem at the individual and population levels. ...
Chronic pain is a common, complex, and distressing problem that has a profound impact on individuals and society. It frequentl
Transition to chronic pain: opportunities for novel therapeutics.
Price TJ, et al. Nat Rev Neurosci 2018. PMID 29765159 Free PMC article.
Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain....
Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in th …
Chronic pain in critical care survivors: a narrative review.
Kemp HI, et al. Br J Anaesth 2019 - Review. PMID 31126622 Free PMC article.
Chronic pain is an important problem after critical care admission. Estimates of the prevalence of chronic pain in the year after discharge range from 14% to 77% depending on the type of cohort, the tool used to measure pain, and the time point when pain was assessed. ...Older age, pre-existing pain, and medical co-morbidity have been associated with pain after critical care admission. No trials were identified of interventions to target chronic pain in survivors specifically. ...
Chronic pain is an important problem after critical care admission. Estimates of the prevalence of chronic pain
Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States.
Yang S and Chang MC. Int J Mol Sci 2019 - Review. PMID 31248061 Free PMC article.
Chronic pain is a condition in which pain progresses from an acute to chronic state and persists beyond the healing process. Chronic pain impairs function and decreases patients' quality of life. In recent years, efforts have been made to deepen our understanding of chronic pain and to develop better treatments to alleviate chronic pain. ...
Chronic pain is a condition in which pain progresses from an acute to chronic state and persists beyond the heal
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