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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 1
1947 5
1948 5
1949 3
1950 15
1951 16
1952 19
1953 12
1954 8
1955 10
1956 13
1957 14
1958 16
1959 13
1960 27
1961 14
1962 17
1963 27
1964 95
1965 100
1966 211
1967 335
1968 385
1969 442
1970 583
1971 631
1972 802
1973 871
1974 995
1975 908
1976 913
1977 802
1978 895
1979 878
1980 958
1981 957
1982 999
1983 1013
1984 1099
1985 1087
1986 1157
1987 1254
1988 1248
1989 1282
1990 1523
1991 1538
1992 1532
1993 1431
1994 1429
1995 1447
1996 1492
1997 1556
1998 1599
1999 1633
2000 1583
2001 1690
2002 1619
2003 1659
2004 1695
2005 1917
2006 1894
2007 2173
2008 2084
2009 2125
2010 2058
2011 1922
2012 2047
2013 2186
2014 2192
2015 2126
2016 1959
2017 2013
2018 1764
2019 670
2020 8
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69,949 results
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Page 1
Neurobiology of Circadian Rhythm Regulation.
Rosenwasser AM and Turek FW. Sleep Med Clin 2015 - Review. PMID 26568118
The circadian timing system is composed of a large number of cellular oscillators located in the SCN, in non-SCN brain structures, and throughout the body. Cellular-level oscillations are generated by a molecular feedback loop in which circadian clock genes rhythmically regulate their own transcription, as well as that of hundreds of clock-controlled genes. ...
The circadian timing system is composed of a large number of cellular oscillators located in the SCN, in non-SCN brain structures, an …
[Circadian rhythm sleep-wake disorder (circadian rhythm sleep disorder)].
Tagaya H, et al. Nihon Rinsho 2015 - Review. PMID 26065124 Japanese.
The role of the circadian system is forecasting the daily and yearly change of environment. Circadian rhythm sleep-wake disorder (CRSWD) is defined as physical and social impairment caused by misalignment between circadian rhythm and desirable social schedule. ...Bright light therapy and orally administered small dose of melatonin or melatonin agonist at proper circadian phase are recommended treatments. ...
The role of the circadian system is forecasting the daily and yearly change of environment. Circadian rhythm sleep-wake disord …
Chronobiology of Aging: A Mini-Review
Cornelissen G and Otsuka K. Gerontology 2017 - Review. PMID 27771728 Free article.
Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. ...Caloric restriction, which is consistently and reproducibly associated with prolonging life in different animal models, is associated with an increased circadian amplitude. ...
Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian
Melatonin: Pharmacology, Functions and Therapeutic Benefits
Tordjman S, et al. Curr Neuropharmacol 2017 - Review. PMID 28503116 Free PMC article.
.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24-hour clock. ...
.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environ …
Melatonin: exceeding expectations
Reiter RJ, et al. Physiology (Bethesda) 2014 - Review. PMID 25180262 Free article.
Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. ...
Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions rela …
Circadian clock proteins and immunity.
Curtis AM, et al. Immunity 2014 - Review. PMID 24560196 Free article.
Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow an organism to anticipate daily changes in activity and feeding and the associated risk of infection or tissue damage to the host. ...
Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circa
Evolution of circadian rhythms: from bacteria to human.
Bhadra U, et al. Sleep Med 2017 - Review. PMID 28619182
This review reports insights into the evolution of the circadian mechanism and its evolutionary shift which is vital and plays a major role in assisting different organisms to adapt in different zones and controls their internal biological clocks with changing external cues....
This review reports insights into the evolution of the circadian mechanism and its evolutionary shift which is vital and plays a majo …
The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
Dibner C, et al. Annu Rev Physiol 2010 - Review. PMID 20148687
., fluctuations in light intensity and temperature), an internal circadian timing system, and the interaction between this timekeeping system and environmental signals. ...Here we discuss knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system....
., fluctuations in light intensity and temperature), an internal circadian timing system, and the interaction between this timekeepin …
Circadian rhythms of liver physiology and disease: experimental and clinical evidence.
Tahara Y and Shibata S. Nat Rev Gastroenterol Hepatol 2016 - Review. PMID 26907879
The circadian clock system consists of a central clock located in the suprachiasmatic nucleus in the hypothalamus and peripheral clocks in peripheral tissues. ...In this Review, we focus on the molecular mechanisms of hepatic circadian gene regulation and the relationships between hepatic circadian clock systems and liver physiology and disease. ...
The circadian clock system consists of a central clock located in the suprachiasmatic nucleus in the hypothalamus and peripheral cloc …
Extraordinary behavioral entrainment following circadian rhythm bifurcation in mice.
Harrison EM, et al. Sci Rep 2016. PMID 27929128 Free PMC article.
The mammalian circadian timing system uses light to synchronize endogenously generated rhythms with the environmental day. Entrainment to schedules that deviate significantly from 24 h (T24) has been viewed as unlikely because the circadian pacemaker appears capable only of small, incremental responses to brief light exposures. Challenging this view, we demonstrate that simple manipulations of light alone induce extreme plasticity in the circadian system of mice. ...
The mammalian circadian timing system uses light to synchronize endogenously generated rhythms with the environmental day. Entrainmen …
69,949 results
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