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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 2
1946 23
1947 26
1948 31
1949 29
1950 52
1951 55
1952 50
1953 67
1954 59
1955 60
1956 60
1957 77
1958 56
1959 66
1960 65
1961 70
1962 68
1963 89
1964 93
1965 44
1966 2
1967 1
1969 1
1974 2
1975 2
1976 1
1978 3
1979 4
1980 21
1981 109
1982 164
1983 170
1984 188
1985 206
1986 201
1987 188
1988 209
1989 218
1990 255
1991 258
1992 225
1993 228
1994 216
1995 199
1996 183
1997 178
1998 204
1999 174
2000 233
2001 245
2002 239
2003 259
2004 273
2005 318
2006 341
2007 337
2008 358
2009 377
2010 402
2011 468
2012 514
2013 511
2014 492
2015 527
2016 535
2017 485
2018 492
2019 279
2020 15
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11,620 results
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Page 1
Effects of sodium citrate, citric acid and lactic acid on human blood coagulation.
Scaravilli V, et al. Perfusion 2018. PMID 29783879
Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. METHODS: In this in vitro study, citric acid, sodium citrate and lactic acid were added to venous blood from seven healthy donors, obtaining concentrations of 9 mEq/L, 12 mEq/L and 15 mEq/L. ...CONCLUSIONS: Citric acid infusions determine acidification and anticoagulation of blood similar to lactic acid and sodium citrate, respectively....
Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. METHODS: In this in …
Continuous citric acid production in repeated-fed batch fermentation by Aspergillus niger immobilized on a new porous foam.
Yu B, et al. J Biotechnol 2018. PMID 29588182
The efficiency of current methods for industrial production of citric acid is limited. To achieve continuous citric acid production with enhanced yield and reduced cost, immobilized fermentation was employed in an Aspergillus niger 831 repeated fed-batch fermentation system. ...Then eight-cycle repeated fed-batch cultures for citric acid production were carried out over 600 h, which showed stable production with maximum citric acid concentrations and productivity levels of 162.7 g/L and 2.26 g L(-1) h(-1), respectively. ...
The efficiency of current methods for industrial production of citric acid is limited. To achieve continuous citric
A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation
Williams NC and O'Neill LAJ. Front Immunol 2018 - Review. PMID 29459863 Free PMC article.
Cytosolic metabolism of citrate to acetyl-coenzyme A (acetyl-CoA) is important for both fatty-acid synthesis and protein acetylation, both of which have been linked to macrophage and DC activation. ...
Cytosolic metabolism of citrate to acetyl-coenzyme A (acetyl-CoA) is important for both fatty-acid synthesis and protein acetylation, …
Citric acid production.
Berovic M and Legisa M. Biotechnol Annu Rev 2007 - Review. PMID 17875481
Citric acid is a commodity chemical produced and consumed throughout The World. It is used mainly in the food and beverage industry, primarily as an acidulant. ...Global production of citric acid in 2007 was over 1.6 million tones. Biochemistry of citric acid fermentation, various microbial strains, as well as various substrates, technological processes and product recovery are presented. ...
Citric acid is a commodity chemical produced and consumed throughout The World. It is used mainly in the food and beverage ind
pH selectively regulates citric acid and lipid production in Yarrowia lipolytica W29 during nitrogen-limited growth on glucose.
Zhang S, et al. J Biotechnol 2019. PMID 30496777
Yarrowia lipolytica has been used to produce both citric acid and lipid-based bioproducts at high titers. In this study, we found that pH differentially affects citric acid and lipid production in Y. lipolytica W29, with citric acid production enhanced at more neutral pH's and lipid production enhanced at more acid pH's. ...These results suggest that this pH-dependent switch is mediated at the level of citric acid transport rather than changes in the expression of the enzymes involved in citric acid and lipid metabolism. ...
Yarrowia lipolytica has been used to produce both citric acid and lipid-based bioproducts at high titers. In this study, we fo …
Optimization of the integrated citric acid-methane fermentation process by air stripping and glucoamylase addition.
Xu J, et al. Bioprocess Biosyst Eng 2015. PMID 25194466
To solve the problem of extraction wastewater in citric acid industry, an integrated citric acid-methane fermentation process was proposed. ...In consequence, citric acid production was significantly improved but still lower by 6.1 % than the control. Results indicated that metal ions in ADE synergistically inhibited the activity of glucoamylase, thus reducing citric acid production. ...
To solve the problem of extraction wastewater in citric acid industry, an integrated citric acid-methane ferment …
Effect of citric acid on setting reaction and tissue response to β-TCP granular cement.
Fukuda N, et al. Biomed Mater 2017. PMID 28233758
As the concentration of citric acid in the acidic calcium phosphate solution increased, the amount of DCPD formation in the set β-TCPGC decreased, and the crystal morphology of DCPD became elongated. β-TCPGC prepared with various citric acid concentrations were used as grafting material in rat calvarial bone defects to evaluate bone regeneration in vivo. ...We concluded, therefore, that citric acid might be a useful retarder of β-TCPGC setting times....
As the concentration of citric acid in the acidic calcium phosphate solution increased, the amount of DCPD formation in …
The impact of harmfulness information on citric acid induced cough and urge-to-cough.
Janssens T, et al. Pulm Pharmacol Ther 2015 - Clinical Trial. PMID 25634521
Using dosimeter-controlled inhalations, the dose of citric acid eliciting at least three coughs (C3) was determined. Next, participants received 4 blocks of randomized presentations of citric acid at the C3 dose, a sub-threshold dose of citric acid and saline control. ...During repeated citric acid presentations, framing the cough-inducing substance as a potentially harmful chemical resulted in a greater urge-to-cough compared to information framing it as natural citric acid (p < .01). ...
Using dosimeter-controlled inhalations, the dose of citric acid eliciting at least three coughs (C3) was determined. Next, par …
[Quantitative measurement of citric acid in urine using tandem liquid chromatography mass spectrometry].
Dong J, et al. Zhonghua Yi Xue Za Zhi 2017. PMID 29275581 Chinese.
Objective: To find a suitable method for the determination of citric acid in the urine of patients with stones, in order to provide a new method and basis for the prevention and treatment of stone. ...Results: The results showed a good linear relationship with the concentration of citric acid in urine. y=50.31x+ 0.002 6 (R(2)=0.994 21). ...
Objective: To find a suitable method for the determination of citric acid in the urine of patients with stones, in order to pr …
Citric acid production patent review.
Anastassiadis S, et al. Recent Pat Biotechnol 2008 - Review. PMID 19075859
Further perspectives aiming in the improvement of citric acid production are the improvement of citric acid producing strains by classical and modern mutagenesis and selection as well as downstream processes. ...Alternatively, continuous processes utilizing yeasts which reach 200-250 g/l citric acid can stand in today's strong competition in citric acid industry and replace the traditional discontinuous fungi processes....
Further perspectives aiming in the improvement of citric acid production are the improvement of citric acid prod …
11,620 results
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