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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 2
1946 23
1947 22
1948 28
1949 26
1950 37
1951 47
1952 39
1953 57
1954 56
1955 56
1956 59
1957 70
1958 47
1959 57
1960 57
1961 63
1962 61
1963 87
1964 86
1965 43
1966 2
1967 1
1969 1
1974 2
1975 2
1976 1
1978 3
1979 4
1980 21
1981 109
1982 164
1983 170
1984 186
1985 205
1986 200
1987 187
1988 208
1989 216
1990 255
1991 258
1992 225
1993 227
1994 215
1995 197
1996 173
1997 154
1998 170
1999 146
2000 201
2001 210
2002 205
2003 217
2004 231
2005 280
2006 289
2007 285
2008 299
2009 332
2010 343
2011 411
2012 451
2013 444
2014 435
2015 474
2016 473
2017 427
2018 431
2019 252
2020 11
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10,526 results
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Effects of sodium citrate, citric acid and lactic acid on human blood coagulation.
Scaravilli V, et al. Perfusion 2018. PMID 29783879
Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. METHODS: In this in vitro study, citric acid, sodium citrate and lactic acid were added to venous blood from seven healthy donors, obtaining concentrations of 9 mEq/L, 12 mEq/L and 15 mEq/L. ...CONCLUSIONS: Citric acid infusions determine acidification and anticoagulation of blood similar to lactic acid and sodium citrate, respectively....
Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. METHODS: In this in …
Citric acid and itaconic acid accumulation: variations of the same story?
Karaffa L and Kubicek CP. Appl Microbiol Biotechnol 2019 - Review. PMID 30758523 Free PMC article.
Both organic acids are formed by the same metabolic pathway, but whereas citric acid is the end product in A. niger, A. terreus performs two additional enzymatic steps leading to itaconic acid. ...These comparative data may facilitate further investigations of citric acid and itaconic acid accumulation and may contribute to improvements in their industrial production....
Both organic acids are formed by the same metabolic pathway, but whereas citric acid is the end product in A. niger, A. terreu …
Engineering of the citrate exporter protein enables high citric acid production in Aspergillus niger.
Steiger MG, et al. Metab Eng 2019. PMID 30553933
Aspergillus niger was engineered using a gene responsible for citric acid transport, which has a significant impact on citric acid secretion when overexpressed. ...The disruption of this gene completely abolishes citric acid secretion, which indicates that this protein is the main citric acid transporter in A. niger. ...
Aspergillus niger was engineered using a gene responsible for citric acid transport, which has a significant impact on citr
Production of high titer of citric acid from inulin.
Rakicka M, et al. BMC Biotechnol 2019. PMID 30744615 Free PMC article.
CONCLUSIONS: The citric acid titer obtained in the proposed process is the highest value reported in the literature for Yarrowia yeast. The obtained results suggest that citric acid production from inulin by engineered Y. lipolytica may be a very promising technology for industrial citric acid production....
CONCLUSIONS: The citric acid titer obtained in the proposed process is the highest value reported in the literature for Yarrow …
Surface Hydrophobicity and Functional Properties of Citric Acid Cross-Linked Whey Protein Isolate: The Impact of pH and Concentration of Citric Acid.
Li T, et al. Molecules 2018. PMID 30231489 Free PMC article.
The effects of citric acid-mediated cross-linking under non-acidic conditions on the surface hydrophobicity, solubility, emulsifying, and foaming properties of whey protein isolate (WPI) were investigated. ...The emulsifying activity and foaming ability of WPI reached a maximum under the condition of 1% citric acid and pH 7.0. However, the solubility of WPI-CA gradually decreased with pH and the content of citric acid increased. ...
The effects of citric acid-mediated cross-linking under non-acidic conditions on the surface hydrophobicity, solubility, emuls …
Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid.
Ryan EM, et al. J Pharm Biomed Anal 2019. PMID 30447534 Free PMC article.
DISCUSSION: Our results indicate that citric acid obstructs accurate uricase-based UA measurement, providing falsely low values. Citric acid, a known antioxidant, scavenges hydrogen peroxide, a key intermediate using the uricase method. By scavenging hydrogen peroxide, citric acid decreases the amount of oxidized leuco dye leading to falsely low UA measurements. ...
DISCUSSION: Our results indicate that citric acid obstructs accurate uricase-based UA measurement, providing falsely low value …
Systems metabolic engineering for citric acid production by Aspergillus niger in the post-genomic era.
Tong Z, et al. Microb Cell Fact 2019 - Review. PMID 30717739 Free PMC article.
Citric acid is the world's largest consumed organic acid and is widely used in beverage, food and pharmaceutical industries. Aspergillus niger is the main industrial workhorse for citric acid production. Since the release of the genome sequence, extensive multi-omic data are being rapidly obtained, which greatly boost our understanding of the citric acid accumulation mechanism in A. niger to a molecular and system level. ...
Citric acid is the world's largest consumed organic acid and is widely used in beverage, food and pharmaceutical indust
Continuous citric acid production in repeated-fed batch fermentation by Aspergillus niger immobilized on a new porous foam.
Yu B, et al. J Biotechnol 2018. PMID 29588182
The efficiency of current methods for industrial production of citric acid is limited. To achieve continuous citric acid production with enhanced yield and reduced cost, immobilized fermentation was employed in an Aspergillus niger 831 repeated fed-batch fermentation system. ...Then eight-cycle repeated fed-batch cultures for citric acid production were carried out over 600 h, which showed stable production with maximum citric acid concentrations and productivity levels of 162.7 g/L and 2.26 g L(-1) h(-1), respectively. ...
The efficiency of current methods for industrial production of citric acid is limited. To achieve continuous citric
Determination and study on refractive indices and viscosities of aqueous solutions of citric acid, (citric acid + glycerol), and (citric acid + d-sorbitol) at T = 293.15 K-323.15 K and atmospheric pressure.
Omran MM, et al. Food Chem 2019. PMID 30955634
Citric acid, glycerol, and d-sorbitol are used as important food additives. In this research work, viscosities and refractive indices (the physico-chemical properties) for aqueous solution of citric acid, as well as ternary solutions of (water + d-sorbitol + citric acid) and (water + glycerol + citric acid) were measured in mass fractions of citric acid (0.03-0.21) and at temperatures (T = 293.15, 303.15, 313.15, and 323.15) K and atmospheric pressure. ...
Citric acid, glycerol, and d-sorbitol are used as important food additives. In this research work, viscosities and refractive
Citric acid mitigates soybean meal induced inflammatory response and tight junction disruption by altering TLR signal transduction in the intestine of turbot, Scophthalmus maximus L.
Zhao S, et al. Fish Shellfish Immunol 2019. PMID 31176009
Four isonitrogenous and isolipidic practical diets were formulated: fish meal-based diet (FM); 40% fish meal protein in FM replaced with soybean meal protein (SBM); SBM + 1.5% citric acid and SBM + 3% citric acid. ...Therefore, citric acid could function on mitigating soybean meal induced enteropathy in the distal intestine of juvenile turbot....
Four isonitrogenous and isolipidic practical diets were formulated: fish meal-based diet (FM); 40% fish meal protein in FM replaced with soy …
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