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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1960 1
1962 5
1963 6
1964 57
1965 1097
1966 1132
1967 1128
1968 1292
1969 1450
1970 1519
1971 1475
1972 1841
1973 2087
1974 2459
1975 2932
1976 2966
1977 3000
1978 3238
1979 2825
1980 2643
1981 3135
1982 3305
1983 3862
1984 4058
1985 4468
1986 4885
1987 4850
1988 4874
1989 5489
1990 4211
1991 1380
1992 1717
1993 2492
1994 3818
1995 4171
1996 4268
1997 4736
1998 5421
1999 6403
2000 6988
2001 8691
2002 10113
2003 11505
2004 12051
2005 11966
2006 12306
2007 11623
2008 13025
2009 14085
2010 14333
2011 14194
2012 13572
2013 13924
2014 13229
2015 13715
2016 14046
2017 13742
2018 13753
2019 6761
2020 140
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336,530 results
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Page 1
Adaptive Designs for Clinical Trials.
Bhatt DL and Mehta C. N Engl J Med 2016 - Review. PMID 27406349 Free article.
Innovation in oncology clinical trial design.
Verweij J, et al. Cancer Treat Rev 2019 - Review. PMID 30665053
The gold standard of randomised confirmatory Phase III trials is not always ethical or feasible when developing drugs for treatment of small cancer populations. Alternative strategies comprise accelerated approval via conditional marketing approval, which can be granted in the EU based on small non-randomised Phase II trials. ...
The gold standard of randomised confirmatory Phase III trials is not always ethical or feasible when developing drugs for treatment o …
Statistical Controversies in Reporting of Clinical Trials: Part 2 of a 4-Part Series on Statistics for Clinical Trials.
Pocock SJ, et al. J Am Coll Cardiol 2015 - Review. PMID 26670066 Free article.
This paper tackles several statistical controversies that are commonly faced when reporting a major clinical trial. Topics covered include: multiplicity of data, interpreting secondary endpoints and composite endpoints, the value of covariate adjustment, the traumas of subgroup analysis, assessing individual benefits and risks, alternatives to analysis by intention to treat, interpreting surprise findings (good and bad), and the overall quality of clinical trial reports. ...
This paper tackles several statistical controversies that are commonly faced when reporting a major clinical trial. Topics covered in …
Clinical trials update 2015: Year in review.
Peroutka SJ. Headache 2016 - Review. PMID 26790852
This section of Headache annually reviews the status of recently completed and ongoing major clinical trials involving common headache disorders. The review will focus on multicenter trials of new therapies, as well as novel formulations of previously approved therapeutics. ...
This section of Headache annually reviews the status of recently completed and ongoing major clinical trials involving common …
Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.
Waubant E, et al. Neurology 2019. PMID 31043474 Free PMC article.
METHODS: The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review the advances in the understanding of pediatric-onset multiple sclerosis (MS) and the advent of clinical trials for this population. ...There are also ethical considerations on conducting clinical trials in this age group including the use of placebo owing to highly active disease. ...
METHODS: The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review the advances in the understandin …
What is the impact of ethics on clinical trials?
Spielman B. Expert Rev Clin Pharmacol 2016. PMID 26414551
Ethics has often been ignored or evaded in clinical trials, and the conditions under which global clinical trials are conducted make this problem likely to persist. ...This editorial provides historical examples of ignoring, evading or, alternatively, using ethical help to improve clinical trials, and suggests that the actual role of ethics depends on the individuals involved....
Ethics has often been ignored or evaded in clinical trials, and the conditions under which global clinical trials
Reappraisal of eligibility criteria in cancer clinical trials.
Penel N, et al. Curr Opin Oncol 2018 - Review. PMID 30020120
PURPOSE OF REVIEW: We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropriate eligibility criteria in cancer clinical trials. ...However, stringent eligibility criteria jeopardize the feasibility of trials, and, consequently, the generalizability of trial results. ...
PURPOSE OF REVIEW: We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropria …
Key design considerations for adaptive clinical trials: a primer for clinicians.
Thorlund K, et al. BMJ 2018. PMID 29519932 Free PMC article.
This article reviews important considerations for researchers who are designing adaptive clinical trials. These differ from conventional clinical trials because they allow and even enforce continual modifications to key components of trial design while data are being collected. ...Adaptive designs have mostly been used in trials evaluating drugs, but their use is spreading. The US Food and Drug Administration recently issued guidance on adaptive trial designs, which highlighted general principles and different types of adaptive clinical trials but did not provide concrete guidance about important considerations in designing such trials. ...
This article reviews important considerations for researchers who are designing adaptive clinical trials. These differ from co …
International Clinical Trial Day and clinical trials in Ethiopia and Africa.
Fekadu A, et al. Trials 2014. PMID 25526797 Free PMC article.
The motto for the day was 'Clinical Trials for Excellence in Patient Care'. The celebration offered an opportunity to inform academic staff, researchers, students and the leadership about clinical trials being conducted and to discuss the future of clinical trials in the country. ...In this commentary we reflect on the celebration of ICTD, the status and opportunities for conducting clinical trials and the way forward for facilitating clinical trials in Ethiopia and Africa....
The motto for the day was 'Clinical Trials for Excellence in Patient Care'. The celebration offered an opportunity to inform a …
Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy.
Tunis SR, et al. JAMA 2003. PMID 14506122
Clinical trials for which the hypothesis and study design are developed specifically to answer the questions faced by decision makers are called pragmatic or practical clinical trials (PCTs). ...The supply of PCTs is limited primarily because the major funders of clinical research, the National Institutes of Health and the medical products industry, do not focus on supporting such trials. ...
Clinical trials for which the hypothesis and study design are developed specifically to answer the questions faced by decision
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