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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 16
2006 56
2007 47
2008 41
2009 53
2010 53
2011 83
2012 90
2013 73
2014 73
2015 64
2016 67
2017 59
2018 48
2019 23
2020 1
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730 results
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Page 1
Regulation of Clusterin Gene Expression.
Garcia-Aranda M, et al. Curr Protein Pept Sci 2018 - Review. PMID 28925903
Clusterin is a multifunctional glycoprotein whose role in cells has generated a great controversy in recent years. Since its discovery, numerous studies have linked clusterin expression deregulation with various physio-pathological processes such as cancer or Alzheimer's disease. ...These results, together with the breakthrough of gene therapies, have motivated a great effort to elucidate the importance of clusterin as a potential therapeutic target. ...
Clusterin is a multifunctional glycoprotein whose role in cells has generated a great controversy in recent years. Since its discover
Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes.
Pereira RM, et al. Heart Fail Rev 2018 - Review. PMID 28948410
In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarction, transplant, or myocarditis. Clusterin can act directly or indirectly on apoptosis by regulating several intracellular pathways. ...
In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardio …
Divergent roles for Clusterin in Lung Injury and Repair.
Habiel DM, et al. Sci Rep 2017. PMID 29133960 Free PMC article.
Herein, we report that extracellular Clusterin promoted epithelial cell apoptosis whereas intracellular Clusterin maintained epithelium viability during lung repair. Unlike normal and COPD lungs, IPF lungs were characterized by significantly increased extracellular Clusterin whereas the inverse was evident for intracellular Clusterin. ...
Herein, we report that extracellular Clusterin promoted epithelial cell apoptosis whereas intracellular Clusterin maintained e …
Paracrine crosstalk between endothelial cells and melanocytes through clusterin to inhibit pigmentation.
Kim M, et al. Exp Dermatol 2018. PMID 28887822
To investigate the paracrine effect of clusterin from HDMECs on the regulation of melanogenesis, HDMECs were infected with clusterin or sh-clusterin lentivirus and the HDMEC-derived conditioned media were used to treat normal human melanocytes. It was found that HDMEC-derived clusterin inhibits melanogenesis through MITF/tyrosinase downregulation. The findings here suggest that HDMECs secrete copious amounts of clusterin and that the clusterin is a factor contributing to the inhibitory effect of endothelial cells on melanogenesis via paracrine crosstalk between endothelial cells and melanocytes....
To investigate the paracrine effect of clusterin from HDMECs on the regulation of melanogenesis, HDMECs were infected with cluster
Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis.
Park JS, et al. Biochem Biophys Res Commun 2018. PMID 29229391
Clusterin is a multifunctional glycoprotein that plays important roles and is up-regulated in liver diseases such as hepatitis and hepatocellular carcinoma. However, little is known about the significance of clusterin in the pathogenesis of non-alcoholic steatohepatitis (NASH). The aim of this study is to examine the role of clusterin in progression of steatohepatitis in mice fed a methionine and choline deficient (MCD) diet. ...
Clusterin is a multifunctional glycoprotein that plays important roles and is up-regulated in liver diseases such as hepatitis and he
Mechanisms that minimize retinal impact of apolipoprotein E absence
Saadane A, et al. J Lipid Res 2018. PMID 30333155 Free PMC article.
We found that retinal cholesterol biosynthesis and the levels of retinal cholesterol were increased in Apoe(-/-) mice, whereas cholesterol elimination by metabolism was decreased. ...Therefore, cholesterol biosynthesis inside retinal cells increase, whereas metabolism to oxysterols decreases to prevent cells from cholesterol depletion. ...
We found that retinal cholesterol biosynthesis and the levels of retinal cholesterol were increased in Apoe(-/-) mice, whereas cholesterol e …
Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis.
Peix L, et al. Sci Rep 2018. PMID 29382921 Free PMC article.
Clusterin, an extracellular chaperone and regulator of cell functions, is reduced in bronchoalveolar lavage fluid of patients with pulmonary fibrosis. ...Clusterin also co-localized with elastin in vessel walls and additionally with amorphous elastin deposits in fibrotic lung. Analysis of primary lung fibroblast isolates in vitro confirmed the down-regulation of clusterin expression in fibrotic compared with control lung fibroblasts and further demonstrated that TGF-β(1) is capable of down-regulating fibroblast clusterin expression. shRNA-mediated down-regulation of clusterin did not affect TGF-β(1)-induced fibroblast-myofibroblast differentiation but inhibited fibroblast proliferative responses and sensitized to apoptosis. ...
Clusterin, an extracellular chaperone and regulator of cell functions, is reduced in bronchoalveolar lavage fluid of patients with pu
MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin.
Zhu Y, et al. EBioMedicine 2018. PMID 29628342 Free PMC article.
In CRC cells, MEG3 over-expression is related to decreased Clusterin mRNA and the corresponding protein levels, and it also directly binds to Clusterin protein through its 732-1174 region. In further, Clusterin over-expression rescues the compromised abilities of proliferation and metastasis induced by MEG3 over-expression, suggesting that MEG3 inhibits the CRC progression through regulating the Clusterin activities. ...
In CRC cells, MEG3 over-expression is related to decreased Clusterin mRNA and the corresponding protein levels, and it also directly …
Clusterin promotes growth and invasion of clear cell renal carcinoma cell by upregulation of S100A4 expression.
Liu Y, et al. Cancer Biomark 2018. PMID 29400663
METHODS: We have established stable transfectants of highly invasive Caki-1 human RCC cells with expression of clusterin shRNA targeting clusterin (Caki-1/clusterin shRNA). ...Clusterin and S100A4 expression was detected by reverse transcription (RT) PCR and western blot assay; Caki-1/clusterin shRNA and 786-O/clusterin cDNA clones were subjected to in vitro-invasion assays. ...
METHODS: We have established stable transfectants of highly invasive Caki-1 human RCC cells with expression of clusterin shRNA target …
Clusterin, a Novel DEC1 Target, Modulates DNA Damage-Mediated Cell Death.
Ming X, et al. Mol Cancer Res 2018. PMID 30002194 Free article.
Secretory clusterin (sCLU) is a cytoprotective protein that guards against genotoxic stresses. Here, clusterin (CLU) was identified as a novel target gene of DEC1 and suppresses DNA damage-induced cell death in tumor cells. ...
Secretory clusterin (sCLU) is a cytoprotective protein that guards against genotoxic stresses. Here, clusterin (CLU) was ident …
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