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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1118
1844 1248
1845 1277
1846 1406
1847 1367
1848 1203
1849 1207
1850 1126
1851 1228
1852 1310
1853 1558
1854 1306
1855 1586
1856 1587
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2179
1878 2454
1879 2399
1880 2646
1881 3149
1882 2742
1883 3126
1884 3049
1885 3337
1886 3291
1887 3965
1888 4002
1889 4194
1890 4024
1891 3607
1892 4080
1893 4370
1894 3801
1895 4129
1896 4412
1897 4689
1898 4631
1899 4169
1900 3785
1901 3886
1902 3967
1903 3910
1904 4059
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5105
1914 5135
1915 4640
1916 4543
1917 4281
1918 4567
1919 4619
1920 4960
1921 4628
1922 4123
1923 4432
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5548
1933 5610
1934 5508
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53739
1947 64968
1948 70726
1949 62805
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108541
1956 107005
1957 111515
1958 109458
1959 109989
1960 112211
1961 120166
1962 125670
1963 141520
1964 162087
1965 176641
1966 179753
1967 191497
1968 207843
1969 215070
1970 218975
1971 222872
1972 227510
1973 230629
1974 234509
1975 248223
1976 250198
1977 249431
1978 257728
1979 264994
1980 266737
1981 271091
1982 282632
1983 294199
1984 302112
1985 318342
1986 330967
1987 347149
1988 363656
1989 377620
1990 382808
1991 380898
1992 382550
1993 390130
1994 401561
1995 410674
1996 420546
1997 417974
1998 435303
1999 452467
2000 488799
2001 501174
2002 519044
2003 546559
2004 588633
2005 647350
2006 692249
2007 729878
2008 777133
2009 816696
2010 879384
2011 955900
2012 1021786
2013 1072823
2014 1126872
2015 1169035
2016 1203317
2017 1227192
2018 1271064
2019 1331755
2020 1527932
2021 1672523
2022 1673803
2023 1586546
2024 1626706
2025 426749

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36,234,312 results

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Quoted phrases not found in phrase index: "Priority Journal", "Hiv Envelope Protein Gp160 Chemistry Metabolism", "Hiv Infections Metabolism Virology", "Subtilisins Chemistry Metabolism"
Page 1
Ribonuclease S redux.
Watkins RW, Arnold U, Raines RT. Watkins RW, et al. Chem Commun (Camb). 2011 Jan 21;47(3):973-5. doi: 10.1039/c0cc03864d. Epub 2010 Nov 16. Chem Commun (Camb). 2011. PMID: 21079871 Free PMC article.
The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic activity. Although this archetypal protein-fragment complementation system has been the object of historic work in protein che …
The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic act …
Carbohydrates of human immunodeficiency virus.
Hansen JE. Hansen JE. APMIS Suppl. 1992;27:96-108. APMIS Suppl. 1992. PMID: 1520531 Review.
For anti-viral therapy in AIDS, inhibitors of glycosylation enzymes are very promising as their mode of action may preclude evolvement of resistent HIV substrains, which seems to be a common problem with the reverse transcriptase inhibitors presently used. ...
For anti-viral therapy in AIDS, inhibitors of glycosylation enzymes are very promising as their mode of action may preclude evolvement of re …
Advances in protease engineering for laundry detergents.
Vojcic L, Pitzler C, Körfer G, Jakob F, Ronny Martinez, Maurer KH, Schwaneberg U. Vojcic L, et al. N Biotechnol. 2015 Dec 25;32(6):629-34. doi: 10.1016/j.nbt.2014.12.010. Epub 2015 Jan 8. N Biotechnol. 2015. PMID: 25579194 Review.
Proteases are essential ingredients in modern laundry detergents. Over the past 30 years, subtilisin proteases employed in the laundry detergent industry have been engineered by directed evolution and rational design to tailor their properties towards industrial demands. T …
Proteases are essential ingredients in modern laundry detergents. Over the past 30 years, subtilisin proteases employed in the laundr …
Enzyme-catalyzed peptide cyclization.
Schmidt M, Toplak A, Quaedflieg PJLM, van Maarseveen JH, Nuijens T. Schmidt M, et al. Drug Discov Today Technol. 2017 Dec;26:11-16. doi: 10.1016/j.ddtec.2017.11.007. Epub 2017 Nov 26. Drug Discov Today Technol. 2017. PMID: 29249237 Review.
Subtilisin-like proteases in nematodes.
Poole CB, Jin J, McReynolds LA. Poole CB, et al. Mol Biochem Parasitol. 2007 Sep;155(1):1-8. doi: 10.1016/j.molbiopara.2007.05.001. Epub 2007 May 6. Mol Biochem Parasitol. 2007. PMID: 17570539 Review.
Cleavage by subtilisin-like proteases (subtilases) is an essential step in post-translational processing of proteins found in organisms ranging from yeast to mammals. ...
Cleavage by subtilisin-like proteases (subtilases) is an essential step in post-translational processing of proteins found in organis …
Engineering subtilisin proteases that specifically degrade active RAS.
Chen Y, Toth EA, Ruan B, Choi EJ, Simmerman R, Chen Y, He Y, Wang R, Godoy-Ruiz R, King H, Custer G, Travis Gallagher D, Rozak DA, Solomon M, Muro S, Weber DJ, Orban J, Fuerst TR, Bryan PN. Chen Y, et al. Commun Biol. 2021 Mar 5;4(1):299. doi: 10.1038/s42003-021-01818-7. Commun Biol. 2021. PMID: 33674772 Free PMC article.
We describe the design, kinetic properties, and structures of engineered subtilisin proteases that degrade the active form of RAS by cleaving a conserved sequence in switch 2. RAS is a signaling protein that, when mutated, drives a third of human cancers. To generat …
We describe the design, kinetic properties, and structures of engineered subtilisin proteases that degrade the active form of RAS by …
Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function.
Hor L, Pilapitiya A, McKenna JA, Panjikar S, Anderson MA, Desvaux M, Paxman JJ, Heras B. Hor L, et al. Nat Commun. 2023 Mar 1;14(1):1163. doi: 10.1038/s41467-023-36719-2. Nat Commun. 2023. PMID: 36859523 Free PMC article.
Although the structures of subtilases have been well documented, this subtilisin-like protein is associated with a 248 residue beta-helix and itself includes three finger-like protrusions around its active site involved in substrate interactions. ...
Although the structures of subtilases have been well documented, this subtilisin-like protein is associated with a 248 residue …
Biocatalytic combinatorial synthesis.
Krstenansky JL, Khmelnitsky Y. Krstenansky JL, et al. Bioorg Med Chem. 1999 Oct;7(10):2157-62. doi: 10.1016/s0968-0896(99)00145-5. Bioorg Med Chem. 1999. PMID: 10579520
Combinatorial biocatalysis, based on a principle of the combinatorial use of biosynthetic steps rather than the combinatorial use of reagents, offers a complementary approach to combinatorial chemistry, which, used individually or in connection with synthetic organic trans …
Combinatorial biocatalysis, based on a principle of the combinatorial use of biosynthetic steps rather than the combinatorial use of reagent …
Molecular and cellular regulation of prohormone processing.
Creemers JW, Jackson RS, Hutton JC. Creemers JW, et al. Semin Cell Dev Biol. 1998 Feb;9(1):3-10. doi: 10.1006/scdb.1997.0195. Semin Cell Dev Biol. 1998. PMID: 9572108 Review.
The processing of prohormones involves cleavage at specific basic amino acids by members of the subtilisin-like serine endoprotease family, followed by trimming of the COOH terminus by carboxypeptidase E. ...
The processing of prohormones involves cleavage at specific basic amino acids by members of the subtilisin-like serine endoprotease f …
Variable Digestion Strategies for Phosphoproteomics Analysis.
Gonczarowska-Jorge H, Dell'Aica M, Dickhut C, Zahedi RP. Gonczarowska-Jorge H, et al. Methods Mol Biol. 2016;1355:225-39. doi: 10.1007/978-1-4939-3049-4_15. Methods Mol Biol. 2016. PMID: 26584929
To overcome these limitations, we introduce an alternative and simple approach based on the usage of the nonspecific serine protease subtilisin, which enables a fast and reproducible digestion and provides access to "hidden" areas of the proteome. ...While the overlap was …
To overcome these limitations, we introduce an alternative and simple approach based on the usage of the nonspecific serine protease subt …
36,234,312 results
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