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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 8
1996 25
1997 34
1998 63
1999 93
2000 123
2001 144
2002 160
2003 171
2004 177
2005 168
2006 203
2007 176
2008 191
2009 205
2010 189
2011 220
2012 206
2013 215
2014 202
2015 161
2016 175
2017 165
2018 131
2019 62
2020 0
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3,353 results
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CpG islands and the regulation of transcription.
Deaton AM and Bird A. Genes Dev 2011 - Review. PMID 21576262 Free PMC article.
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. ...Silencing of CGI promoters is achieved through dense CpG methylation or polycomb recruitment, again using their distinctive DNA sequence composition. ...
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern …
CpG islands--'a rough guide'.
Illingworth RS and Bird AP. FEBS Lett 2009 - Review. PMID 19376112 Free article.
Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). ...
Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands
CpG Islands: A Historical Perspective.
Antequera F and Bird A. Methods Mol Biol 2018. PMID 29605844
The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium. ...
The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecul …
Orphan CpG islands as alternative promoters.
Sarda S and Hannenhalli S. Transcription 2018. PMID 29099304 Free PMC article.
CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. ...
CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, w
Preservation of methylated CpG dinucleotides in human CpG islands.
Panchin AY, et al. Biol Direct 2016. PMID 27005429 Free PMC article.
BACKGROUND: CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher. This observation is usually explained by lower CpG > TpG substitution rates within CGIs due to reduced cytosine methylation levels. ...
BACKGROUND: CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG
CpG Islands in Cancer: Heads, Tails, and Sides.
Ferreira HJ and Esteller M. Methods Mol Biol 2018. PMID 29605847
This CpG dinucleotide modification cooperates in the regulation of the output of the cellular genetic content, in both healthy and pathological conditions. ...When these dinucleotides are organized in dense regions are called CpG islands (CGIs), being commonly known as transcriptional regulatory regions frequently associated with the promoter region of several genes. ...
This CpG dinucleotide modification cooperates in the regulation of the output of the cellular genetic content, in both healthy and pa …
Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells.
Takahashi Y, et al. Science 2017. PMID 28473583 Free PMC article.
CpG islands (CGIs) are primarily promoter-associated genomic regions and are mostly unmethylated within highly methylated mammalian genomes. ...Here we show that insertion of CpG-free DNA into targeted CGIs induces de novo methylation of the entire CGI in human pluripotent stem cells (PSCs). ...
CpG islands (CGIs) are primarily promoter-associated genomic regions and are mostly unmethylated within highly methylated mamm
CG dinucleotides enhance promoter activity independent of DNA methylation
Hartl D, et al. Genome Res 2019. PMID 30709850 Free PMC article.
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in CpGs and devoid of DNA methylation. ...However, this CpG contribution to promoter activity is independent of DNA methyltransferase activity. Together, this refines our understanding of mammalian promoter regulation as it shows that high CpG density within CpG islands directly contributes to an environment permissive for full transcriptional activity....
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in CpGs and devoid of DNA methylation. …
Factors to preserve CpG-rich sequences in methylated CpG islands.
Miyahara H, et al. BMC Genomics 2015. PMID 25879481 Free PMC article.
BACKGROUND: Mammalian CpG islands (CGIs) normally escape DNA methylation in all adult tissues and developmental stages. However, in our previous study we unexpectedly identified many methylated CGIs in human peripheral blood leukocytes. Methylated CpG dinucleotides convert to TpG dinucleotides through deaminization of their cytosine bases more frequently than hypomethylated CpG dinucleotides. ...
BACKGROUND: Mammalian CpG islands (CGIs) normally escape DNA methylation in all adult tissues and developmental stages. Howeve …
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.
Long HK, et al. Biochem Soc Trans 2013 - Review. PMID 23697932 Free PMC article.
Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. ...In contrast with DNA methylation, which is found broadly across vertebrate genomes, non-methylated DNA is concentrated in regions known as CGIs (CpG islands). ...
Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. …
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