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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1960 1
1961 1
1962 2
1963 1
1964 10
1965 6
1966 6
1967 9
1968 20
1969 17
1970 18
1971 24
1972 35
1973 25
1974 45
1975 62
1976 54
1977 81
1978 80
1979 95
1980 115
1981 119
1982 152
1983 147
1984 153
1985 232
1986 259
1987 311
1988 374
1989 440
1990 591
1991 716
1992 886
1993 1000
1994 1261
1995 1320
1996 1527
1997 1582
1998 1825
1999 1931
2000 2137
2001 2135
2002 2281
2003 2431
2004 2627
2005 2810
2006 2862
2007 3058
2008 3074
2009 3147
2010 3371
2011 3527
2012 3759
2013 4211
2014 4339
2015 4693
2016 4742
2017 4898
2018 4992
2019 4989
2020 5265
2021 5434
2022 4924
2023 4551
2024 3439
2025 12

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98,069 results

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Page 1
Micropatterned nanolayers immobilized with nerve growth factor for neurite formation of PC12 cells.
Kim SM, Ueki M, Ren X, Akimoto J, Sakai Y, Ito Y. Kim SM, et al. Int J Nanomedicine. 2019 Sep 19;14:7683-7694. doi: 10.2147/IJN.S217416. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31571871 Free PMC article.
BACKGROUND: Nerve regeneration is important for the treatment of degenerative diseases and neurons injured by accidents. Nerve growth factor (NGF) has been previously conjugated to materials for promotion of neurogenesis. ...NGF was quantitatively immobilized …
BACKGROUND: Nerve regeneration is important for the treatment of degenerative diseases and neurons injured by accidents. Nerve gro …
Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway.
Cui H, Shao C, Liu Q, Yu W, Fang J, Yu W, Ali A, Ding K. Cui H, et al. Biochem J. 2011 Dec 1;440(2):273-82. doi: 10.1042/BJ20110167. Biochem J. 2011. PMID: 21831044
Heparanase is involved in the cleavage of the HS (heparan sulfate) chain of HSPGs (HS proteoglycans) and hence participates in remodelling of the ECM (extracellular matrix) and BM (basement membrane). In the present study we have shown that NGF (nerve growth fact …
Heparanase is involved in the cleavage of the HS (heparan sulfate) chain of HSPGs (HS proteoglycans) and hence participates in remodelling o …
The Heterogeneity of Response of PC12 Cells from Different Laboratories to Nerve Growth Factor and Pituitary Adenylate Cyclase-Activating Polypeptide Questions the Reproducibility of Studies Carried Out with Tumor Cell Lines.
Delage C, Breard-Mellin L, Thérésine C, Simioneck S, Lefranc B, Leprince J, Bénard M, Vaudry D. Delage C, et al. Neuroendocrinology. 2023;113(2):216-230. doi: 10.1159/000518337. Epub 2021 Jul 9. Neuroendocrinology. 2023. PMID: 34348336
BACKGROUND: PC12 pheochromocytoma tumor cell lines are widely used to decipher the intracellular signaling mechanisms mediating the effects of some growth factors. ...This led us to analyze the phenotypic aspect and transcriptomic expression of 5 PC12 cell lines fro …
BACKGROUND: PC12 pheochromocytoma tumor cell lines are widely used to decipher the intracellular signaling mechanisms mediating the e …
Different responses of PC12 cells to different pro-nerve growth factor protein variants.
Soligo M, Albini M, Bertoli FL, Marzano V, Protto V, Bracci-Laudiero L, Minnone G, De Benedetti F, Chiaretti A, Mantuano E, Manni L. Soligo M, et al. Neurochem Int. 2019 Oct;129:104498. doi: 10.1016/j.neuint.2019.104498. Epub 2019 Jul 3. Neurochem Int. 2019. PMID: 31278975
The present work aimed to explore the innovative hypothesis that different transcript/protein variants of a pro-neurotrophin may generate different biological outcomes in a cellular system. Nerve growth factor (NGF) is important in the development and progres …
The present work aimed to explore the innovative hypothesis that different transcript/protein variants of a pro-neurotrophin may generate di …
Disentangling the signaling complexity of nerve growth factor receptors by CRISPR/Cas9.
Testa G, Mainardi M, Vannini E, Pancrazi L, Cattaneo A, Costa M. Testa G, et al. FASEB J. 2022 Nov;36(11):e22498. doi: 10.1096/fj.202101760RR. FASEB J. 2022. PMID: 37036720
The binding of nerve growth factor (NGF) to the tropomyosin-related kinase A (TrkA) and p75(NTR) receptors activates a large variety of pathways regulating critical processes as diverse as proliferation, differentiation, membrane potential, synaptic plasticit …
The binding of nerve growth factor (NGF) to the tropomyosin-related kinase A (TrkA) and p75(NTR) receptors activates a …
GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.
Li J, Fang J, Qin Y, Liao W, Liu H, Zhou Y, Ding K. Li J, et al. Biochem J. 2014 Apr 15;459(2):405-15. doi: 10.1042/BJ20131360. Biochem J. 2014. PMID: 24499487
In the present study we showed that GLCE depletion caused arrested PC12 cell growth and promoted the cell neuritogenesis and differentiation induced by NGF (nerve growth factor). PC12 cell growth was boosted by overexpression of GLCE, and neurit …
In the present study we showed that GLCE depletion caused arrested PC12 cell growth and promoted the cell neuritogenesis and differen …
Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor.
Matsushima Y, Terada K, Kamei C, Sugimoto Y. Matsushima Y, et al. Eur J Pharmacol. 2019 Jun 15;853:129-135. doi: 10.1016/j.ejphar.2019.03.032. Epub 2019 Mar 19. Eur J Pharmacol. 2019. PMID: 30902656
The selective serotonin reuptake inhibitors (SSRIs) fluvoxamine and sertraline show a high affinity for sigma-1 receptors. Fluvoxamine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells via a sigma-1 receptor-mediated mechanism, …
The selective serotonin reuptake inhibitors (SSRIs) fluvoxamine and sertraline show a high affinity for sigma-1 receptors. Fluvoxamine enhan …
Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells.
Takito J, Kimura J, Kajima K, Uozumi N, Watanabe M, Yokosuka A, Mimaki Y, Nakamura M, Ohizumi Y. Takito J, et al. Can J Physiol Pharmacol. 2016 Jul;94(7):728-33. doi: 10.1139/cjpp-2015-0394. Epub 2016 Feb 12. Can J Physiol Pharmacol. 2016. PMID: 27128150
We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal models of memory loss and activated the cAMP responsive element (CRE)-dependent transcription in PC12 cells. Nobiletin activated the cA …
We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal mo …
Nerve growth factor-induced decrease in the calpain activity of PC12 cells.
Oshima M, Koizumi S, Fujita K, Guroff G. Oshima M, et al. J Biol Chem. 1989 Dec 5;264(34):20811-6. J Biol Chem. 1989. PMID: 2555371 Free article.
PC12 cells are a nerve growth factor-responsive clone derived from a rat pheochromocytoma. ...These studies suggest that nerve growth factor causes a decrease in the activity of calpain in morphologically differentiating PC12 …
PC12 cells are a nerve growth factor-responsive clone derived from a rat pheochromocytoma. ...These studies sugg …
Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells.
Chen MC, Lin H, Hsu FN, Huang PH, Lee GS, Wang PS. Chen MC, et al. Am J Physiol Cell Physiol. 2010 Aug;299(2):C516-27. doi: 10.1152/ajpcell.00534.2009. Epub 2010 May 12. Am J Physiol Cell Physiol. 2010. PMID: 20463173 Free article.
The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of t …
The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model syst …
98,069 results
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