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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1981 1
1991 13
1992 43
1993 29
1994 53
1995 35
1996 45
1997 59
1998 64
1999 88
2000 78
2001 114
2002 119
2003 139
2004 165
2005 143
2006 176
2007 191
2008 182
2009 209
2010 275
2011 281
2012 336
2013 441
2014 495
2015 520
2016 496
2017 526
2018 539
2019 203
2020 2
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5,460 results
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Page 1
Immunonutrition in Critical Illness: What Is the Role?
McCarthy MS and Martindale RG. Nutr Clin Pract 2018. PMID 29878555
Agreement is still lacking about the value of individual immune-modulating substrates for specific patient populations. However, it has long been agreed that there are 3 primary targets for these substrates: 1) mucosal barrier function, 2) cellular defense function, and 3) local and systemic inflammation. ...This overview of immunonutrition will discuss the evidence for its role in critical illness today....
Agreement is still lacking about the value of individual immune-modulating substrates for specific patient populations. …
Chronic Critical Illness: Application of What We Know.
Rosenthal MD, et al. Nutr Clin Pract 2018 - Review. PMID 29323761 Free PMC article.
Over the last decade, chronic critical illness (CCI) has emerged as an epidemic in intensive care unit (ICU) survivors worldwide. ...Many MOF survivors, however, experience a persistent dysregulated immune response that is causing an increasingly predominant clinical phenotype called the persistent inflammation, immunosuppression, and catabolism syndrome (PICS). ...
Over the last decade, chronic critical illness (CCI) has emerged as an epidemic in intensive care unit (ICU
Critical Illness in Patients With Asplenia.
O'Neal HR, et al. Chest 2016 - Review. PMID 27068019
Because of the relatively small size of this population and the relative infrequency with which critical illness occurs in it, there are few controlled trials that can serve as a basis for therapeutic maneuvers; thus, optimal management requires an astute clinician with an understanding of the pathogenetic mechanisms underlying the reported consequences of splenectomy. The purpose of this review is to explore the pathophysiology of the asplenic state-impairment in adaptive immunity, loss of blood filtration, endothelial dysfunction, and dysregulated coagulation-and how it leads to infection, thrombosis, and pulmonary hypertension as well as to discuss the implications of these conditions on the management of the critically ill, splenectomized patient....
Because of the relatively small size of this population and the relative infrequency with which critical illness occurs …
Gastrointestinal Tract Dysfunction With Critical Illness: Clinical Assessment and Management.
Hill TL. Top Companion Anim Med 2019 - Review. PMID 31122688
The gut is the site of digestion and absorption as well as serving as an endocrine and immune organ. All of these functions may be affected by critical illness. This review will discuss secondary effects of critical illness on the gut in terms of gastrointestinal function that is clinically observable and discuss consequences of gut dysfunction with critical illness to patient outcome. ...
The gut is the site of digestion and absorption as well as serving as an endocrine and immune organ. All of these functions ma …
Metabolic response to the stress of critical illness.
Preiser JC, et al. Br J Anaesth 2014 - Review. Among authors: Ichai C. PMID 24970271 Free article.
The metabolic response to stress is part of the adaptive response to survive critical illness. Several mechanisms are well preserved during evolution, including the stimulation of the sympathetic nervous system, the release of pituitary hormones, a peripheral resistance to the effects of these and other anabolic factors, triggered to increase the provision of energy substrates to the vital tissues. ...The loss of muscle proteins and function is a major long-term consequence of stress metabolism. Specific therapeutic interventions, including hormone supplementation, enhanced protein intake, and early mobilization, are investigated. ...
The metabolic response to stress is part of the adaptive response to survive critical illness. Several mechanisms are w …
[Personalized therapy: the cornerstone of development in critical care medicine].
Liu D. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019. PMID 30707859 Chinese.
Critical therapy is a goal-directed personalized treatment according to the real-time changes of critical illness and the body's response to intervention, based on the theory of critical care medicine. ...The personalized critical therapy is moving towards more feasible and accurate, and is promoting the overall development of critical care medicine....
Critical therapy is a goal-directed personalized treatment according to the real-time changes of critical illness
Exercise rehabilitation following intensive care unit discharge for recovery from critical illness: executive summary of a Cochrane Collaboration systematic review.
Connolly B, et al. J Cachexia Sarcopenia Muscle 2016 - Review. PMID 27891297 Free PMC article.
Skeletal muscle wasting and weakness are major complications of critical illness and underlie the profound physical and functional impairments experienced by survivors after discharge from the intensive care unit (ICU). ...We were unable to determine an overall effect on functional exercise capacity or health-related quality of life of interventions initiated after ICU discharge for survivors of critical illness. ...
Skeletal muscle wasting and weakness are major complications of critical illness and underlie the profound physical and functi …
Nutrition in critical illness.
Kelly MK and Collins J. Crit Care Nurs Clin North Am 2014. PMID 24878213
Rapid-response teams
Jones DA, et al. N Engl J Med 2011 - Review. PMID 21751906
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