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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 4
1995 31
1996 76
1997 129
1998 196
1999 275
2000 292
2001 337
2002 287
2003 346
2004 353
2005 350
2006 336
2007 340
2008 336
2009 343
2010 329
2011 319
2012 296
2013 303
2014 276
2015 262
2016 214
2017 183
2018 140
2019 58
2020 0
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5,866 results
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Page 1
The cyclin-dependent kinase inhibitor p27 kip1 regulates radial stem cell quiescence and neurogenesis in the adult hippocampus.
Andreu Z, et al. Stem Cells 2015. PMID 25185890 Free article.
Members of the cyclin-dependent kinase (CDK)-inhibitory protein (CIP)/kinase-inhibitory protein (KIP) family of cyclin-dependent kinase inhibitors regulate proliferation and cell cycle exit of mammalian cells. ...Analysis of animals carrying a disruption in the cyclin-CDK interaction domain of p27(kip1) indicates that the CDK inhibitory function of the protein is necessary to control the activity of radial stem cells. ...
Members of the cyclin-dependent kinase (CDK)-inhibitory protein (CIP)/kinase-inhibitory protein (KIP) family of …
SGK1-Sensitive Regulation of Cyclin-Dependent Kinase Inhibitor 1B (p27) in Cardiomyocyte Hypertrophy.
Voelkl J, et al. Cell Physiol Biochem 2015. PMID 26344141 Free article.
SGK1 phosphorylation targets include cyclin-dependent kinase inhibitor 1B (p27), a protein which suppresses cardiac hypertrophy. ...Moreover, isoproterenol treatment stimulated the hypertrophic response and was followed by disappearance of p27 from the nuclei, effects prevented by the SGK1 inhibitor EMD638683. ...
SGK1 phosphorylation targets include cyclin-dependent kinase inhibitor 1B (p27), a protein which suppress …
Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: A double-edged sword protein.
Abbastabar M, et al. DNA Repair (Amst) 2018 - Review. PMID 30075372
Cyclin dependent kinase inhibitor p27 (also known as KIP(1)) is a factor that inhibits the progression of the cell cycle by using specific molecular mechanisms. ...Post- translational modification of p27 by phosphorylation and ubiquitination respectively regulates interaction between p27 and cyclin/CDK complex and degradation of p27. ...
Cyclin dependent kinase inhibitor p27 (also known as KIP(1)) is a factor that inhibits the progression of
Genetic association between the cyclin-dependent kinase inhibitor gene p27/Kip1 polymorphism (rs34330) and cancer susceptibility: a meta-analysis.
Cheng XK, et al. Sci Rep 2017. PMID 28317869 Free PMC article.
The p27 rs34330 (-79C/T) polymorphism has been widely studied for human cancer susceptibility. The current findings, however, still remained controversial. ...The association of p27 rs34330 polymorphism and cancer susceptibility was estimated with odds ratios and corresponding 95% confidence intervals. ...
The p27 rs34330 (-79C/T) polymorphism has been widely studied for human cancer susceptibility. The current findings, however, still r …
Upregulation of p27 cyclin-dependent kinase inhibitor and a C-terminus truncated form of p27 contributes to G1 phase arrest.
Satoh T and Kaida D. Sci Rep 2016. PMID 27282251 Free PMC article.
SSA treatment caused upregulation of the p27 cyclin-dependent kinase inhibitor both at mRNA and protein levels. In addition to p27, we observed expression of p27*, a C-terminal truncated form of p27 that is translated from CDKN1B (p27) pre-mRNA accumulated after splicing inhibition. ...There results suggest that G1 arrest in SSA-treated cells is caused, at least in part, by upregulation of p27 and p27*....
SSA treatment caused upregulation of the p27 cyclin-dependent kinase inhibitor both at mRNA and protein l …
Cyclin-dependent kinase inhibitor p27 as a prognostic biomarker and potential cancer therapeutic target.
Hershko DD. Future Oncol 2010 - Review. PMID 21142858
This article presents the current knowledge on the prognostic significance of p27 expression in cancer and its potential role as a target for future therapy....
This article presents the current knowledge on the prognostic significance of p27 expression in cancer and its potential role as a ta …
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation.
Tsytlonok M, et al. Nat Commun 2019. PMID 30976006 Free PMC article.
p27(Kip1) is an intrinsically disordered protein (IDP) that inhibits cyclin-dependent kinase (Cdk)/cyclin complexes (e.g., Cdk2/cyclin A), causing cell cycle arrest. Cell division progresses when stably Cdk2/cyclin A-bound p27 is phosphorylated on one or two structurally occluded tyrosine residues and a distal threonine residue (T187), triggering degradation of p27. ...
p27(Kip1) is an intrinsically disordered protein (IDP) that inhibits cyclin-dependent kinase (Cdk)/cyclin
Lack of association between cyclin-dependent kinase inhibitor 1B rs2066827 polymorphism and breast cancer susceptibility.
Jia ZM, et al. Tumour Biol 2014. PMID 24523023
Based on this meta-analysis, we conclude that the cyclin-dependent kinase inhibitor 1B rs2066827 polymorphism might not be a risk factor for breast cancer development. Further studies, either with larger sample size or involving other SNPs and haplotypes of the cyclin-dependent kinase inhibitor 1B gene, are necessary to clarify the contribution of cyclin-dependent kinase inhibitor 1B rs2066827 in breast carcinogenesis....
Based on this meta-analysis, we conclude that the cyclin-dependent kinase inhibitor 1B rs2066827 polymorphism mi …
Overexpression of cyclin dependent kinase inhibitor P27/Kip1 increases oligodendrocyte differentiation from induced pluripotent stem cells.
Tamaki S and Tokumoto Y. In Vitro Cell Dev Biol Anim 2014. PMID 24764126
The results showed that the expression levels of cyclin dependent kinase inhibitor P27/Kip1, mitogen-activated protein kinase (MAPK) JNK3, and transcription factor Mash1 were lower in iPSC-derived cells. ...Although the overexpression of Mash1 had no effect, the overexpression of P27/Kip1 increased the differentiation efficiency of iPSC-derived cells into O4(+) OLs....
The results showed that the expression levels of cyclin dependent kinase inhibitor P27/Kip1, mitogen-acti …
p27(Kip1) and human cancers: A reappraisal of a still enigmatic protein.
Bencivenga D, et al. Cancer Lett 2017 - Review. PMID 28687353
p27(Kip1) is a cell cycle regulator firstly identified as a cyclin-dependent kinase inhibitor. For a long time, its function has been associated to cell cycle progression inhibition at G1/S boundary in response to antiproliferative stimuli. The picture resulted complicated by the discovery that p27(Kip1) is an intrinsically unstructured protein, with numerous CDK-dependent and -independent functions and involvement in many cellular processes, such as cytoskeleton dynamics and cell motility control, apoptosis and autophagy activation. ...
p27(Kip1) is a cell cycle regulator firstly identified as a cyclin-dependent kinase inhibitor. For a long
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