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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1964 1
1965 35
1966 100
1967 123
1968 138
1969 139
1970 186
1971 175
1972 173
1973 171
1974 192
1975 203
1976 216
1977 247
1978 268
1979 264
1980 334
1981 377
1982 474
1983 432
1984 553
1985 655
1986 709
1987 779
1988 1026
1989 1220
1990 1418
1991 1696
1992 1976
1993 2360
1994 2723
1995 3076
1996 3455
1997 3687
1998 3868
1999 4138
2000 4397
2001 4608
2002 4817
2003 4988
2004 4981
2005 5467
2006 5972
2007 6519
2008 7004
2009 6987
2010 7308
2011 7800
2012 7963
2013 8122
2014 8343
2015 8375
2016 8170
2017 7692
2018 7247
2019 2978
2020 46
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152,811 results
Results by year
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Page 1
Biology of IL-38 and its role in disease
van de Veerdonk FL, et al. Immunol Rev 2018 - Review. PMID 29247986
IL-38 belongs to the IL-36 cytokines, which in turn are part of the IL-1 family. The first biological function of IL-38 described was blocking the activation of the IL-36R signaling similar to IL-36Ra. Since IL-36 cytokines require processing in order to become fully active, it is likely that IL-38 also must be processed to become maximally active. ...
IL-38 belongs to the IL-36 cytokines, which in turn are part of the IL-1 family. The first biological function of IL-38 described was …
Differential Regulation of Type I and Type III Interferon Signaling
Stanifer ML, et al. Int J Mol Sci 2019 - Review. PMID 30901970 Free PMC article.
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. ...Since the discovery of type III IFNs, the last 15 years of research in the IFN field has focused on understanding whether the induction, the signaling and the function of these powerful cytokines are regulated differently compared to type I IFN-mediated immune response. ...
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation a …
Cytokines IL-17 and IL-22 in the host response to infection.
Valeri M and Raffatellu M. Pathog Dis 2016 - Review. PMID 27915228 Free PMC article.
Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and in the development of chronic inflammatory diseases. These cytokines are produced by cells that are often located in epithelial barriers, including subsets of T cells and innate lymphoid cells. ...
Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and in the development of chronic inflammatory diseases
Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer
Yan J, et al. Cold Spring Harb Perspect Biol 2018 - Review. PMID 28716888 Free PMC article.
The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. ...
The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or pr …
Inflammasome-independent regulation of IL-1-family cytokines.
Netea MG, et al. Annu Rev Immunol 2015 - Review. PMID 25493334
Induction, production, and release of proinflammatory cytokines are essential steps to establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce inflammation and regulate T lymphocyte responses while also displaying homeostatic and metabolic activities. ...However, increasing evidence suggests that inflammasomes and caspase-1 are not the only mechanism for processing IL-1 cytokines. ...
Induction, production, and release of proinflammatory cytokines are essential steps to establish an effective host defense. Cytoki
Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines.
Kheirandish-Gozal L and Gozal D. Int J Mol Sci 2019 - Review. PMID 30678164 Free PMC article.
Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients....
Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory …
Into the eye of the cytokine storm
Tisoncik JR, et al. Microbiol Mol Biol Rev 2012 - Review. PMID 22390970 Free PMC article.
The cytokine storm has captured the attention of the public and the scientific community alike, and while the general notion of an excessive or uncontrolled release of proinflammatory cytokines is well known, the concept of a cytokine storm and the biological consequences of cytokine overproduction are not clearly defined. ...
The cytokine storm has captured the attention of the public and the scientific community alike, and while the general notion of an excessive …
[Effect of proinflammatory factors TNF-α,IL-1β, IL-6 on neuropathic pain]
Li QY, et al. Zhongguo Zhong Yao Za Zhi 2017 - Review. PMID 29235283 Chinese.
Cytokines can be divided into two types: proinflammatory cytokines and anti-inflammatory cytokines. Proinflammatory cytokines are a kind of small molecular peptides synthesized and excreted by immune and non-immune cells, which can regulate a variety of physiological functions and play an important role in the process of trauma, pain and infection. ...In recent years, with the deepening of studies on neuropathic pain mechanism and the increasing expansion of the neuroinflammation study field, the action mechanisms of cytokines and molecules in regulating cytokines in neuropathic pain are expected to provide new targets for the development of analgesic drugs. ...
Cytokines can be divided into two types: proinflammatory cytokines and anti-inflammatory cytokines. Proinflammatory
The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?
Artlett CM. Immunol Lett 2018 - Review. PMID 29203183
IL-36 also belongs to the IL-1 family of cytokines and is a new comer to this field of research. Recent analyses of the IL-1 family of cytokines have demonstrated that many of them play a role in skin inflammation and fibrosis and their corresponding antagonists (IL-1RA and IL-36RA) can abrogate this pathology. Understanding how these cytokines are regulated and how they contribute to fibrosis will be important to understanding this pathology and may shed light in new areas for therapeutic development....
IL-36 also belongs to the IL-1 family of cytokines and is a new comer to this field of research. Recent analyses of the IL-1 family o …
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family
Sziksz E, et al. Mediators Inflamm 2015 - Review. PMID 26199463 Free PMC article.
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines....
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) c …
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