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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 3
1998 18
1999 14
2000 27
2001 46
2002 66
2003 78
2004 38
2005 87
2006 123
2007 159
2008 244
2009 271
2010 266
2011 219
2012 267
2013 233
2014 239
2015 202
2016 265
2017 252
2018 265
2019 194
2020 1
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3,128 results
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Page 1
Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity
Vincent BM, et al. Cell Rep 2018. PMID 30517862 Free article.
Using unbiased phenotypic screening, we identified a series of compounds that were cytoprotective against α-syn-mediated toxicity by inhibiting the highly conserved enzyme stearoyl-CoA desaturase (SCD). ...
Using unbiased phenotypic screening, we identified a series of compounds that were cytoprotective against α-syn-mediated toxicity by …
Hepatoprotective activity of metformin: A new mission for an old drug?
Iranshahy M, et al. Eur J Pharmacol 2019 - Review. PMID 30753869
However, the beneficial effects of metformin are not limited to insulin sensitizing and blood glucose lowering effects as recent clinical trials deciphered lower cancer risk in metformin users. ...Clinical trials are under way to assess possible additive effects of metformin when co-administered along with the standard regimen for hepatocellular carcinoma (HCC) treatment. ...
However, the beneficial effects of metformin are not limited to insulin sensitizing and blood glucose lowering effects as rece …
Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase
Hinman A, et al. PLoS One 2018. PMID 30110365 Free PMC article.
To elucidate the biochemical mechanism of vitamin E activity, we systematically investigated the effects of its major vitamers and metabolites on lipid oxidation and ferroptosis in a striatal cell model. ...We propose that, similar to the other lipophilic vitamins A, D and K, vitamin E is instead a pro-vitamin, with its quinone/hydroquinone metabolites responsible for its anti-ferroptotic cytoprotective activity....
To elucidate the biochemical mechanism of vitamin E activity, we systematically investigated the effects of its major vitamers and me …
Protective effects of Ginkgo biloba L. against natural toxins, chemical toxicities, and radiation: A comprehensive review.
Omidkhoda SF, et al. Phytother Res 2019 - Review. PMID 31429152
A few clinical studies have been conducted in this field, which demonstrated the beneficial effects of GB against toxic agents. However, the promising effects of this valuable herbal extract will practically remain useless without carrying out more clinical studies and proving its effects on human beings....
A few clinical studies have been conducted in this field, which demonstrated the beneficial effects of GB against toxic agents. Howev …
Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa.
Qiu ZK, et al. Biomed Pharmacother 2018. PMID 30075369
The astrocyte cells were cultured and AC-5216 (TSPO ligand) was selected as the positive control drug. The cytoprotective effects of PF and the levels of neurosteroids were quantified by water-soluble tetrazolium assay and enzyme linked immunosorbent assay, respectively. ...In summary, the cytoprotective effects of PF maybe mediated by TSPO and neurosteroids biosynthesis. The findings may provide the new insights into the cytoprotective effects of PF....
The astrocyte cells were cultured and AC-5216 (TSPO ligand) was selected as the positive control drug. The cytoprotective e
Pharmacological Properties of Biocompounds from Spores of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes): A Review
Soccol CR, et al. Int J Med Mushrooms 2016 - Review. PMID 27910768
In addition, the major active components identified and their biological properties, such as neurological activity and antiaging and cell-protective effects, are investigated because these are of importance for potential drug development....
In addition, the major active components identified and their biological properties, such as neurological activity and antiaging and cell-pr …
Effects of Eicosapentaenoic Acid on the Cytoprotection Through Nrf2-Mediated Heme Oxygenase-1 in Human Endothelial Cells.
Lee SE, et al. J Cardiovasc Pharmacol 2015. PMID 25815672
The aim of this study was to investigate whether heme oxygenase-1 (HO-1) induction contributes to the cytoprotective effects of EPA in endothelial cells threatened with oxidative damage. ...
The aim of this study was to investigate whether heme oxygenase-1 (HO-1) induction contributes to the cytoprotective effects o …
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