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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1966 1
1973 1
1974 1
1975 7
1976 6
1977 35
1978 171
1979 229
1980 241
1981 279
1982 303
1983 336
1984 408
1985 420
1986 375
1987 472
1988 687
1989 847
1990 942
1991 929
1992 964
1993 1043
1994 949
1995 1144
1996 1012
1997 903
1998 766
1999 988
2000 1073
2001 1054
2002 1177
2003 1580
2004 1642
2005 1522
2006 2020
2007 2701
2008 3172
2009 4148
2010 4163
2011 4300
2012 4527
2013 3997
2014 3761
2015 3613
2016 2871
2017 2900
2018 2734
2019 1615
2020 104
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61,381 results
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Page 1
Single-Molecule Analysis of Bacterial DNA Repair and Mutagenesis.
Uphoff S and Sherratt DJ. Annu Rev Biophys 2017 - Review. PMID 28375733
Then again, inaccuracies in DNA transactions and failures to remove mutagenic lesions cause heritable genome changes. Building on decades of research using genetics and biochemistry, unprecedented quantitative insight into DNA repair mechanisms has come from the new-found ability to measure single proteins in vitro and inside individual living cells. This has brought together biologists, chemists, engineers, physicists, and mathematicians to solve long-standing questions about the way in which repair enzymes search for DNA lesions and form protein complexes that act in DNA repair pathways. ...
Then again, inaccuracies in DNA transactions and failures to remove mutagenic lesions cause heritable genome changes. Building on dec …
Multifaceted roles of extracellular DNA in bacterial physiology.
Vorkapic D, et al. Curr Genet 2016 - Review. PMID 26328805 Free PMC article.
The origin of extracellular DNA in such ecological niches is diverse: it can be actively secreted or released by prokaryotic and eukaryotic cells by means of autolysis, apoptosis, necrosis, bacterial secretion systems or found in association with extracellular bacterial membrane vesicles. ...Herein, we discuss briefly the main origins of extracellular DNA and the most relevant roles for the bacterial physiology, such as biofilm formation, nutrient source, antimicrobial means and horizontal gene transfer....
The origin of extracellular DNA in such ecological niches is diverse: it can be actively secreted or released by prokaryotic and euka …
Structure of bacterial chromosome: An analysis of DNA-protein interactions in vivo.
Hołówka J and Płachetka M. Postepy Hig Med Dosw (Online) 2017 - Review. PMID 29225199 Free article.
According to recent reports, bacterial chromosomes exhibit a hierarchical organization. The number of proteins that bind DNA are responsible for local and global organization of the DNA ensuring proper chromosome compaction. Advanced molecular biology techniques combined with high-throughput DNA sequencing methods allow a precise analysis of bacterial chromosome structures on a local and global scale. ...
According to recent reports, bacterial chromosomes exhibit a hierarchical organization. The number of proteins that bind DNA a …
The Divided Bacterial Genome: Structure, Function, and Evolution.
diCenzo GC and Finan TM. Microbiol Mol Biol Rev 2017 - Review. PMID 28794225 Free PMC article.
Approximately 10% of bacterial genomes are split between two or more large DNA fragments, a genome architecture referred to as a multipartite genome. ...The availability of many complete bacterial genome sequences means that we can now examine on a broad scale the characteristics of the different types of DNA molecules in a genome. ...
Approximately 10% of bacterial genomes are split between two or more large DNA fragments, a genome architecture referred to as …
Single-molecule live-cell imaging of bacterial DNA repair and damage tolerance.
Ghodke H, et al. Biochem Soc Trans 2018 - Review. PMID 29196610
Genomic DNA is constantly under threat from intracellular and environmental factors that damage its chemical structure. Uncorrected DNA damage may impede cellular propagation or even result in cell death, making it critical to restore genomic integrity. ...In this review, we will cover practical aspects of single-molecule live-cell imaging and highlight recent advances accomplished by the application of these experimental approaches to the study of DNA-repair processes in prokaryotes....
Genomic DNA is constantly under threat from intracellular and environmental factors that damage its chemical structure. Uncorrected …
Next-generation sequencing (NGS) in the microbiological world: How to make the most of your money
Vincent AT, et al. J Microbiol Methods 2017 - Review. PMID 26995332
The Sanger sequencing method produces relatively long DNA sequences of unmatched quality and has been considered for long time as the gold standard for sequencing DNA. ...NGS allowed scientists to sequence thousands to millions of DNA molecules in a single machine run. Since then, new NGS technologies have emerged and existing NGS platforms have been improved, enabling the production of genome sequences at an unprecedented rate as well as broadening the spectrum of NGS applications. ...
The Sanger sequencing method produces relatively long DNA sequences of unmatched quality and has been considered for long time as the …
Implementation and Data Analysis of Tn-seq, Whole-Genome Resequencing, and Single-Molecule Real-Time Sequencing for Bacterial Genetics.
Burby PE, et al. J Bacteriol 2016 - Review. PMID 27672193 Free PMC article.
Although application of newer sequencing technologies to studies in bacterial genetics is increasing, the implementation of DNA sequencing technologies and development of the bioinformatics tools required for analyzing the large data sets generated remain a challenge for many. In this minireview, we have chosen to summarize three sequencing approaches that are particularly useful for bacterial genetics. ...
Although application of newer sequencing technologies to studies in bacterial genetics is increasing, the implementation of …
The evolution of bacterial DNA base composition.
Agashe D and Shankar N. J Exp Zool B Mol Dev Evol 2014 - Review. PMID 24610535
Bacterial genomes exhibit a large amount of variation in their base composition, which ranges from 13% to 75% GC. The evolution and maintenance of this variation has proved to be an enduring puzzle despite decades of theoretical and empirical work. ...We close with a discussion of open questions and fruitful avenues of inquiry that may bring us closer to understanding the evolutionary dynamics of bacterial DNA base composition....
Bacterial genomes exhibit a large amount of variation in their base composition, which ranges from 13% to 75% GC. The evolution and m
Multilocus sequence analysis (MLSA) in prokaryotic taxonomy
Glaeser SP and Kämpfer P. Syst Appl Microbiol 2015 - Review. PMID 25959541
However, MLSA is not only suggested as a phylogenetic tool to support and clarify the resolution of bacterial species with a higher resolution, as in 16S rRNA gene-based studies, but has also been discussed as a replacement for DNA-DNA hybridization (DDH) in species delineation. ...
However, MLSA is not only suggested as a phylogenetic tool to support and clarify the resolution of bacterial species with a higher r …
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