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Year Number of Results
2002 1
2005 1
2006 14
2007 42
2008 31
2009 32
2010 24
2011 31
2012 41
2013 37
2014 24
2015 20
2016 21
2017 25
2018 21
2019 7
2020 0
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323 results
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The relationship between DNA single-stranded damage response and double-stranded damage response.
Ma A and Dai X. Cell Cycle 2018. PMID 29157089 Free PMC article.
The research has been focused on damage response of DNA single-stranded breaks or DNA double-stranded breaks. However, when single-stranded breaks and double-stranded breaks exist simultaneously, the DNA damage response remains to be elucidated. ...Firstly, when two kinds of damage are present at the same time, the response of p53 is graded, it means that p53 responds to single-stranded breaks preferentially; Secondly, DNA single-stranded breaks are repaired preferentially, and single-stranded breaks and double-stranded breaks can be repaired simultaneously after most of single-stranded breaks having been repaired; Moreover, single-stranded breaks are more likely to cause apoptosis, because the accumulation of p53 in DNA single-stranded breaks is faster than it in DNA double-stranded breaks and single-stranded breaks has lower threshold of apoptosis....
The research has been focused on damage response of DNA single-stranded breaks or DNA double-stranded
Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.
Ganguly A, et al. PLoS Genet 2018. PMID 30148840 Free PMC article.
Here, genome-wide quantitative functional profiling, DDR measurements and genetic interaction assays in Schizosaccharomyces pombe reveal a chromate toxicogenomic profile that closely resembles the cancer chemotherapeutic drug camptothecin (CPT), which traps Topoisomerase 1 (Top1)-DNA covalent complex (Top1cc) at the 3' end of single-stand breaks (SSBs), resulting in replication fork collapse. ATR/Rad3-dependent checkpoints that detect stalled and collapsed replication forks are crucial in Cr(VI)-treated cells, as is Mus81-dependent sister chromatid recombination (SCR) that repairs single-ended double-strand breaks (seDSBs) at broken replication forks. ...
Here, genome-wide quantitative functional profiling, DDR measurements and genetic interaction assays in Schizosaccharomyces pombe reveal a c …
Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells.
Yellowhair M, et al. Toxicol Appl Pharmacol 2018. PMID 29698738 Free PMC article.
This indicates that UA is producing single strand breaks and forming UA-DNA adducts rather than double strand breaks in CHO cells. ...These results indicate that DU induces DNA damage via strand breaks and uranium-DNA adducts in treated cells. These results suggest that: (1) DU is genotoxic in CHO cells, and (2) DU is inducing single strand breaks rather than double strand breaks in vitro....
This indicates that UA is producing single strand breaks and forming UA-DNA adducts rather than double strand breaks
Imaging DNA single-strand breaks generated by reactive oxygen species using a liquid crystal-based sensor.
Kim HJ and Jang CH. Anal Biochem 2018. PMID 29920235
DNA single-strand breaks (SSBs) have attracted much interest since they are highly related to carcinogenesis and ageing. Herein, we report a new liquid crystal (LC)-based sensor for the detection of DNA SSBs generated by reactive oxygen species (ROS) created from the Fenton reaction. The adsorption of single-stranded DNA (ssDNA) onto the cationic surfactant-laden aqueous/LC interface interferes with the surfactant layer, inducing a planar orientation of the LCs. ...
DNA single-strand breaks (SSBs) have attracted much interest since they are highly related to carcinogenesis and ageing
Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
Eustermann S, et al. Mol Cell 2015. PMID 26626479 Free PMC article.
Poly(ADP-ribose)polymerase 1 (PARP-1) is a key eukaryotic stress sensor that responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic damage. ...Automodification in cis explains the subsequent release of monomeric PARP-1 from DNA, allowing repair and replication to proceed. ...
Poly(ADP-ribose)polymerase 1 (PARP-1) is a key eukaryotic stress sensor that responds in seconds to DNA single-strand break
Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks.
Xu Y, et al. Biol Reprod 2017. PMID 28453612 Free PMC article.
MEIOB (meiosis specific with OB domains), a meiosis-specific single-stranded DNA-binding homolog of replication protein A1 (RPA1), is essential for meiotic recombination. ...Furthermore, MEIOB and SPATA22 are recruited to induced DNA double-strand breaks (DSBs) together but not alone. These results demonstrate the cooperative property of the MEIOB-SPATA22 complex in its interaction with RPA and recruitment to DSBs....
MEIOB (meiosis specific with OB domains), a meiosis-specific single-stranded DNA-binding homolog of replication protein …
DNA single-strand break-induced DNA damage response causes heart failure.
Higo T, et al. Nat Commun 2017. PMID 28436431 Free PMC article.
The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogenesis of heart failure remain elusive. Here we show the critical role of DNA single-strand break (SSB) in the pathogenesis of pressure overload-induced heart failure. ...
The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed …
Coordination of DNA single strand break repair.
Abbotts R and Wilson DM. Free Radic Biol Med 2017 - Review. PMID 27890643 Free PMC article.
Both exogenous and endogenous mechanisms are associated with a high risk of single strand breakage, either produced directly or generated as intermediates of DNA repair. This review will focus upon the creation, consequences and resolution of single strand breaks, with a particular focus on two major coordinating repair proteins: poly(ADP-ribose) polymerase 1 (PARP1) and X-ray repair cross-complementing protein 1 (XRCC1)....
Both exogenous and endogenous mechanisms are associated with a high risk of single strand breakage, either produced directly or gener …
Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ.
Driessens N, et al. Endocr Relat Cancer 2009. PMID 19509065
DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer but their induction by hydrogen peroxide (H(2)O(2)) is still controversial. ...Scores of DNA damage, in terms of strand breaks, were obtained by comet assay (alkaline condition for single-strand breaks (SSBs) and neutral condition for DSBs). ...
DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer but their induction by hydrogen peroxide
Kinetic aspects of enzyme-mediated repair of DNA single-strand breaks.
Zhdanov VP. Biosystems 2016. PMID 27771386
In cells and bacteria, DNA can be damaged in different ways. The efficient damage repair, mediated by various enzymes, is crucial for their survival. Most frequently, the damage is reduced to single-strand breaks. In human cells, according to the experiments, the repair of such breaks can mechanistically be divided into four steps including (i) the break detection, (ii) processing of damaged ends, (iii) gap filling, and (iv) ligation of unbound ends of the broken strand. ...
In cells and bacteria, DNA can be damaged in different ways. The efficient damage repair, mediated by various enzymes, is crucial for …
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