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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1948 4
1951 2
1953 1
1954 3
1955 5
1956 2
1957 1
1958 2
1960 2
1961 7
1962 6
1963 8
1964 4
1965 4
1968 4
1969 2
1974 11
1976 2
1977 1
1978 2
1979 2
1980 15
1981 5
1982 3
1983 5
1984 5
1985 8
1986 169
1987 380
1988 491
1989 548
1990 514
1991 559
1992 579
1993 695
1994 851
1995 861
1996 1010
1997 1050
1998 1064
1999 1193
2000 1227
2001 1356
2002 1425
2003 1431
2004 1589
2005 1724
2006 1905
2007 1958
2008 2010
2009 1954
2010 2061
2011 2170
2012 2265
2013 2213
2014 2109
2015 2242
2016 2088
2017 2113
2018 1812
2019 910
2020 20
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Search Results

42,561 results
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Page 1
Mechanisms of DNA damage, repair, and mutagenesis.
Chatterjee N and Walker GC. Environ Mol Mutagen 2017 - Review. PMID 28485537 Free PMC article.
However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. ...In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue. ...
However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the …
The DNA-damage response in human biology and disease.
Jackson SP and Bartek J. Nature 2009 - Review. PMID 19847258 Free PMC article.
This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. ...Our improving understanding of DNA-damage responses is providing new avenues for disease management....
This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has e …
DNA damage foci: Meaning and significance.
Rothkamm K, et al. Environ Mol Mutagen 2015 - Review. PMID 25773265
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci, has revolutionized the detection of these lesions and has enabled studies of the cellular machinery that contributes to their repair. ...Here we aim to review the biological meaning and significance of DNA damage foci, looking specifically at a range of different settings in which such markers of DNA damage and repair are being studied and interpreted....
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumul …
The DNA damage response and cancer therapy.
Lord CJ and Ashworth A. Nature 2012 - Review. PMID 22258607
Genomic instability is one of the most pervasive characteristics of tumour cells and is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells. ...A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease....
Genomic instability is one of the most pervasive characteristics of tumour cells and is probably the combined effect of DNA damage
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
Michelini F, et al. Nat Cell Biol 2017. PMID 29180822 Free PMC article.
The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation. ...Following DNA damage, RNA polymerase II (RNAPII) binds to the MRE11-RAD50-NBS1 complex, is recruited to DSBs and synthesizes damage-induced long non-coding RNAs (dilncRNAs) from and towards DNA ends. ...
The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA dou …
The DNA damage response: ten years after.
Harper JW and Elledge SJ. Mol Cell 2007 - Review. PMID 18082599 Free article.
The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair of DNA damage and resolution of DNA replication problems, coordinating these processes with ongoing cellular physiology. In the past decade, we have witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage. ...
The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair …
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.
Xia J, et al. Cell 2019. PMID 30633903 Free PMC article.
DNA damage provokes mutations and cancer and results from external carcinogens or endogenous cellular processes. However, the intrinsic instigators of endogenous DNA damage are poorly understood. ...Half of the tested human homologs promote DNA damage and mutation when overproduced in human cells, with DNA damage-elevating mechanisms like those in E. coli. ...
DNA damage provokes mutations and cancer and results from external carcinogens or endogenous cellular processes. However, the
The DNA damage response pathway in normal hematopoiesis and malignancies.
Delia D and Mizutani S. Int J Hematol 2017 - Review. PMID 28707218
In mammalian cells, the DNA damage response (DDR) prevents the replication and propagation of DNA errors to the next generation, thus maintaining genomic stability. At the heart of the DDR are the related signaling kinases ATM, ATR, and DNA-PK, which regulate DNA repair and associated events such as cell cycle checkpoints, chromatin remodeling, transcription, and ultimately apoptosis. ...
In mammalian cells, the DNA damage response (DDR) prevents the replication and propagation of DNA errors to the next ge …
The immunological consequences of radiation-induced DNA damage.
Wilkins AC, et al. J Pathol 2019 - Review. PMID 30632153
Inhibitors of the DNA damage response show promise in augmenting this inflammatory IFN response. However, a substantial proportion of tumours show chronic IFN signalling prior to radiotherapy, which paradoxically drives immunosuppression. ...High-quality translational studies of immunological changes occurring during radiotherapy that incorporate intrinsic tumour biology will enable a better understanding of the immunological consequences of radiation-induced DNA damage in patients. ...
Inhibitors of the DNA damage response show promise in augmenting this inflammatory IFN response. However, a substantial propor …
A tough row to hoe: when replication forks encounter DNA damage.
Patel DR and Weiss RS. Biochem Soc Trans 2018 - Review. PMID 30514768 Free PMC article.
Eukaryotic cells continuously experience DNA damage that can perturb key molecular processes like DNA replication. DNA replication forks that encounter DNA lesions typically slow and may stall, which can lead to highly detrimental fork collapse if appropriate protective measures are not executed. ...Recent efforts from multiple laboratories have highlighted several proteins involved in replication fork remodeling and DNA damage response pathways as key regulators of fork stability. ...
Eukaryotic cells continuously experience DNA damage that can perturb key molecular processes like DNA replication. D
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