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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 2
1980 17
1981 27
1982 33
1983 19
1984 23
1985 34
1986 36
1987 25
1988 20
1989 30
1990 31
1991 31
1992 37
1993 48
1994 45
1995 47
1996 64
1997 50
1998 81
1999 79
2000 110
2001 108
2002 112
2003 142
2004 179
2005 186
2006 164
2007 186
2008 165
2009 190
2010 197
2011 213
2012 236
2013 194
2014 205
2015 197
2016 168
2017 178
2018 118
2019 69
2020 1
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3,718 results
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Page 1
Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics.
Dizdaroglu M, et al. Mutat Res 2017 - Review. PMID 28342455
DNA glycosylases remove modified DNA bases from DNA by hydrolyzing the glycosidic bond leaving behind an apurinic/apyrimidinic (AP) site. ...Differences between the substrate specificities and excision kinetics of DNA glycosylases have been found when these two different substrates were used. ...
DNA glycosylases remove modified DNA bases from DNA by hydrolyzing the glycosidic bond leaving behind an
Differential Ability of Five DNA Glycosylases to Recognize and Repair Damage on Nucleosomal DNA.
Olmon ED and Delaney S. ACS Chem Biol 2017. PMID 28085251 Free PMC article.
Damage to genomic DNA leads to mutagenesis and disease. Repair of single base damage is initiated by DNA glycosylases, the first enzymes in the base excision repair pathway. Although eukaryotic packaging of chromosomal DNA in nucleosomes is known to decrease DNA glycosylase efficiency, the impact on individual glycosylases is unclear. ...
Damage to genomic DNA leads to mutagenesis and disease. Repair of single base damage is initiated by DNA glycosylases, …
Hide and seek: How do DNA glycosylases locate oxidatively damaged DNA bases amidst a sea of undamaged bases?
Lee AJ and Wallace SS. Free Radic Biol Med 2017 - Review. PMID 27865982 Free PMC article.
The first step of the base excision repair (BER) pathway responsible for removing oxidative DNA damage utilizes DNA glycosylases to find and remove the damaged DNA base. ...These studies open up a wealth of possibilities for further study in real time of the interactions of DNA glycosylases and other BER enzymes with various DNA substrates....
The first step of the base excision repair (BER) pathway responsible for removing oxidative DNA damage utilizes DNA glycosy
Whole-genome landscape of pancreatic neuroendocrine tumours
Scarpa A, et al. Nature 2017. PMID 28199314
Here we describe the mutational signatures they harbour, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which encodes a DNA glycosylase. Clinically sporadic PanNETs contain a larger-than-expected proportion of germline mutations, including previously unreported mutations in the DNA repair genes MUTYH, CHEK2 and BRCA2. ...
Here we describe the mutational signatures they harbour, including a deficiency in G:C > T:A base excision repair due to inactivation of …
Repair of 8-oxo-7,8-dihydroguanine in prokaryotic and eukaryotic cells: Properties and biological roles of the Fpg and OGG1 DNA N-glycosylases.
Boiteux S, et al. Free Radic Biol Med 2017 - Review. PMID 27903453
In prokaryotic and eukaryotic cells, 8-oxoG is primarily repaired by the base excision repair pathway (BER) initiated by a DNA N-glycosylase, Fpg and OGG1, respectively. ...Other DNA N-glycosylases able to release 8-oxoG from damaged DNA in various organisms will be discussed. Finally, we will report on the role of OGG1 in human disease and the possible use of 8-oxoG DNA N-glycosylases as therapeutic targets....
In prokaryotic and eukaryotic cells, 8-oxoG is primarily repaired by the base excision repair pathway (BER) initiated by a DNA N-g
Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.
Schomacher L, et al. Nat Struct Mol Biol 2016. PMID 26751644 Free PMC article.
DNA 5-methylcytosine is a dynamic epigenetic mark with important roles in development and disease. In the Tet-Tdg demethylation pathway, methylated cytosine is iteratively oxidized by Tet dioxygenases, and unmodified cytosine is restored via thymine DNA glycosylase (Tdg). Here we show that human NEIL1 and NEIL2 DNA glycosylases coordinate abasic-site processing during TET-TDG DNA demethylation. ...
DNA 5-methylcytosine is a dynamic epigenetic mark with important roles in development and disease. In the Tet-Tdg demethylation pathw
Processing of N(5)-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3.
Minko IG, et al. DNA Repair (Amst) 2019. PMID 30448017 Free PMC article.
The β species are predominant in double-stranded (ds) DNA. Recently, we have demonstrated that the DNA glycosylase NEIL1 can initiate repair of AFB(1)-Fapy-dG adducts both in vitro and in vivo, with Neil1(-/-) mice showing an increased susceptibility to AFB(1)-induced hepatocellular carcinoma. Here, we hypothesized that NEIL1 could excise NM-Fapy-dG and that NEIL3, a closely related DNA glycosylase, could excise both NM-Fapy-dG and AFB(1)-Fapy-dG. ...
The β species are predominant in double-stranded (ds) DNA. Recently, we have demonstrated that the DNA glycosylase NEIL …
Single nucleotide polymorphisms in DNA glycosylases: From function to disease.
D'Errico M, et al. Free Radic Biol Med 2017 - Review. PMID 27932076
Most oxidatively induced DNA base lesions are repaired by the base excision repair (BER) pathway which involves the action of various DNA glycosylases. ...This overview provides a convincing picture that SNPs of DNA glycosylases that remove oxidatively generated DNA lesions are susceptibility factors for a wide disease spectrum that includes besides cancer (particularly lung, breast and gastrointestinal tract), cochlear/ocular disorders, myocardial infarction and neurodegenerative disorders which can be all grouped under the umbrella of oxidative stress-related pathologies....
Most oxidatively induced DNA base lesions are repaired by the base excision repair (BER) pathway which involves the action of various …
Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases.
Shi R, et al. Bioessays 2018 - Review. PMID 30264543
DNA glycosylases remove aberrant DNA nucleobases as the first enzymatic step of the base excision repair (BER) pathway. The alkyl-DNA glycosylases AlkC and AlkD adopt a unique structure based on α-helical HEAT repeats. ...Here, we review the phylogeny, biochemistry, and structures of the HLR proteins, which have helped broaden our understanding of the mechanisms by which DNA glycosylases locate and excise chemically modified DNA nucleobases....
DNA glycosylases remove aberrant DNA nucleobases as the first enzymatic step of the base excision repair (BER) pathway.
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