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Year Number of Results
1989 1
2002 1
2003 38
2004 97
2005 115
2006 131
2007 129
2008 130
2009 148
2010 150
2011 176
2012 209
2013 167
2014 161
2015 160
2016 128
2017 128
2018 93
2019 53
2020 0
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1,922 results
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Page 1
Single nucleotide polymorphisms in DNA glycosylases: From function to disease.
D'Errico M, et al. Free Radic Biol Med 2017 - Review. PMID 27932076
Most oxidatively induced DNA base lesions are repaired by the base excision repair (BER) pathway which involves the action of various DNA glycosylases. ...This overview provides a convincing picture that SNPs of DNA glycosylases that remove oxidatively generated DNA lesions are susceptibility factors for a wide disease spectrum that includes besides cancer (particularly lung, breast and gastrointestinal tract), cochlear/ocular disorders, myocardial infarction and neurodegenerative disorders which can be all grouped under the umbrella of oxidative stress-related pathologies....
Most oxidatively induced DNA base lesions are repaired by the base excision repair (BER) pathway which involves the action of various …
DNA glycosylases: in DNA repair and beyond.
Jacobs AL and Schär P. Chromosoma 2012 - Review. PMID 22048164 Free PMC article.
DNA glycosylases play a key role in the elimination of such DNA lesions; they recognize and excise damaged bases, thereby initiating a repair process that restores the regular DNA structure with high accuracy. ...DNA glycosylases have been brought into context with molecular processes relating to innate and adaptive immunity as well as to the control of DNA methylation and epigenetic stability. ...
DNA glycosylases play a key role in the elimination of such DNA lesions; they recognize and excise damaged bases, there
Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases.
Schormann N, et al. Protein Sci 2016 - Review. PMID 27684934 Free PMC article.
Uracil-DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil-DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA. ...
Uracil-DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genom …
Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-Myc-induced B-cell lymphomagenesis.
Green B, et al. Exp Hematol 2018. PMID 29496532
Therefore, we investigated the role of Ogg1 and UNG glycosylases in c-Myc-driven lymphomagenesis but found that their deficiencies did not influence disease outcome in the Eµ c-Myc mouse model. ...
Therefore, we investigated the role of Ogg1 and UNG glycosylases in c-Myc-driven lymphomagenesis but found that their deficiencies di …
The effect of sleep deprivation and disruption on DNA damage and health of doctors.
Cheung V, et al. Anaesthesia 2019 - Clinical Trial. PMID 30675716
DNA damage and expression of DNA repair genes were quantified. Information on health, working patterns and sleep diaries were collected. ...Increased DNA damage has been linked to the development of chronic disease. This study demonstrates that disrupted sleep is associated with DNA damage. ...
DNA damage and expression of DNA repair genes were quantified. Information on health, working patterns and sleep diaries were
Active DNA demethylation mediated by DNA glycosylases.
Zhu JK. Annu Rev Genet 2009 - Review. PMID 19659441 Free PMC article.
Active DNA demethylation is involved in many vital developmental and physiological processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis have demonstrated that a subfamily of DNA glycosylases function to promote DNA demethylation through a base excision-repair pathway. These specialized bifunctional DNA glycosylases remove the 5-methylcytosine base and then cleave the DNA backbone at the abasic site, resulting in a gap that is then filled with an unmethylated cytosine nucleotide by as yet unknown DNA polymerase and ligase enzymes. ...
Active DNA demethylation is involved in many vital developmental and physiological processes of plants and animals. Recent genetic an …
A combinatorial role for MutY and Fpg DNA glycosylases in mutation avoidance in Mycobacterium smegmatis.
Hassim F, et al. Mutat Res 2015. PMID 26125998
In addition, the formamidopyrimidine (Fpg/MutM) and MutY DNA glycosylases have also been implicated in mutation avoidance and BER in mycobacteria. ...Taken together these data indicate that the mycobacterial mutY, in combination with the Fpg DNA N-glycosylases, plays an important role in controlling mutagenesis under oxidative stress....
In addition, the formamidopyrimidine (Fpg/MutM) and MutY DNA glycosylases have also been implicated in mutation avoidance and …
Oxidative DNA glycosylases: recipes from cloning to characterization.
Bandaru V, et al. Methods Enzymol 2006. PMID 16793360
This chapter attempts to provide a primer for cloning, expression, and assay procedures for bacterial and human DNA glycosylases that recognize oxidative DNA damages. These methodologies can be translated readily to novel DNA glycosylases or to DNA glycosylases that recognize other types of DNA damages....
This chapter attempts to provide a primer for cloning, expression, and assay procedures for bacterial and human DNA glycosylases
MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.
Sjolund AB, et al. Mutat Res 2013 - Review. PMID 23195996 Free PMC article.
The base excision repair system is vital to the repair of endogenous and exogenous DNA damage. This pathway is initiated by one of several DNA glycosylases that recognizes and excises specific DNA lesions in a coordinated fashion. Methyl-CpG Domain Protein 4 (MBD4) and Thymine DNA Glycosylase (TDG) are the two major G:T glycosylases that remove thymine generated by the deamination of 5-methylcytosine. ...
The base excision repair system is vital to the repair of endogenous and exogenous DNA damage. This pathway is initiated by one of se …
Recent advances in the structural mechanisms of DNA glycosylases.
Brooks SC, et al. Biochim Biophys Acta 2013 - Review. PMID 23076011 Free PMC article.
DNA glycosylases safeguard the genome by locating and excising a diverse array of aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. ...Work over the past several years has unraveled details for how the various DNA glycosylases survey DNA, detect damage within the duplex, select for the correct modification, and catalyze base excision. ...
DNA glycosylases safeguard the genome by locating and excising a diverse array of aberrant nucleobases created from oxidation,
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