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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1974 1
1980 3
1981 1
1982 2
1983 1
1994 2
1995 2
1996 67
1997 217
1998 208
1999 247
2000 323
2001 428
2002 511
2003 583
2004 681
2005 726
2006 864
2007 948
2008 1032
2009 1129
2010 1474
2011 1665
2012 1914
2013 2106
2014 2331
2015 2338
2016 2457
2017 2466
2018 2368
2019 1095
2020 21
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25,223 results
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Page 1
DNA methylation in mammals.
Li E and Zhang Y. Cold Spring Harb Perspect Biol 2014 - Review. PMID 24789823 Free PMC article.
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is involved in various biological processes including the silencing of transposable elements, regulation of gene expression, genomic imprinting, and X-chromosome inactivation. This article describes how DNA methylation serves as a cellular memory system and how it is dynamically regulated through the action of the DNA methyltransferase (DNMT) and ten eleven translocation (TET) enzymes. ...
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is involved in various biological pro
DNA methylation-based biomarkers and the epigenetic clock theory of ageing.
Horvath S and Raj K. Nat Rev Genet 2018 - Review. PMID 29643443
In a recent breakthrough, biomarkers of ageing based on DNA methylation data have enabled accurate age estimates for any tissue across the entire life course. ...
In a recent breakthrough, biomarkers of ageing based on DNA methylation data have enabled accurate age estimates for any tissu …
Establishing, maintaining and modifying DNA methylation patterns in plants and animals.
Law JA and Jacobsen SE. Nat Rev Genet 2010 - Review. PMID 20142834 Free PMC article.
Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and transposon silencing, imprinting and X chromosome inactivation. ...Drawing on insights from both plants and animals should deepen our understanding of the regulation and biological significance of DNA methylation....
Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and tran …
Role of TET enzymes in DNA methylation, development, and cancer.
Rasmussen KD and Helin K. Genes Dev 2016 - Review. PMID 27036965 Free PMC article.
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. ...
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methyla
Function and information content of DNA methylation.
Schübeler D. Nature 2015 - Review. PMID 25592537
Cytosine methylation is a DNA modification generally associated with transcriptional silencing. Factors that regulate methylation have been linked to human disease, yet how they contribute to malignances remains largely unknown. Genomic maps of DNA methylation have revealed unexpected dynamics at gene regulatory regions, including active demethylation by TET proteins at binding sites for transcription factors. ...
Cytosine methylation is a DNA modification generally associated with transcriptional silencing. Factors that regulate methy
Readers of DNA methylation, the MBD family as potential therapeutic targets.
Ginder GD and Williams DC. Pharmacol Ther 2018 - Review. PMID 29128342 Free PMC article.
DNA methylation represents a fundamental epigenetic modification that regulates chromatin architecture and gene transcription. Many diseases, including cancer, show aberrant methylation patterns that contribute to the disease phenotype. DNA methylation inhibitors have been used to block methylation dependent gene silencing to treat hematopoietic neoplasms and to restore expression of developmentally silenced genes. ...
DNA methylation represents a fundamental epigenetic modification that regulates chromatin architecture and gene transcription.
Genomic DNA methylation: the mark and its mediators.
Klose RJ and Bird AP. Trends Biochem Sci 2006 - Review. PMID 16403636
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability. ...Recent studies have illuminated the role of DNA methylation in controlling gene expression and have strengthened its links with histone modification and chromatin remodelling....
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essen
Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.
Saghafinia S, et al. Cell Rep 2018. PMID 30355485 Free article.
Here, we designed an algorithmic approach (RESET) to identify aberrant DNA methylation and associated cis-transcriptional changes across >6,000 human tumors. ...Our results provide a pan-cancer map of aberrant DNA methylation to inform functional and therapeutic studies....
Here, we designed an algorithmic approach (RESET) to identify aberrant DNA methylation and associated cis-transcriptional chan …
Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.
Rulands S, et al. Cell Syst 2018. PMID 30031774 Free PMC article.
Exit from pluripotency and priming for differentiation into somatic lineages is associated with genome-wide de novo DNA methylation. We show that during this phase, co-expression of enzymes required for DNA methylation turnover, DNMT3s and TETs, promotes cell-to-cell variability in this epigenetic mark. ...
Exit from pluripotency and priming for differentiation into somatic lineages is associated with genome-wide de novo DNA methylatio
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