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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1971 3
1974 1
1975 1
1977 1
1978 20
1979 47
1980 55
1981 64
1982 62
1983 87
1984 176
1985 241
1986 300
1987 423
1988 728
1989 1106
1990 1782
1991 2516
1992 3102
1993 4075
1994 5298
1995 6783
1996 7768
1997 9060
1998 10067
1999 11243
2000 12460
2001 13793
2002 14720
2003 15836
2004 17883
2005 19221
2006 20648
2007 21664
2008 22951
2009 24437
2010 25822
2011 28204
2012 29512
2013 30486
2014 30433
2015 30409
2016 29086
2017 28675
2018 27534
2019 12575
2020 199
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471,587 results
Results by year
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Page 1
Subcellular localisation of the stem cell markers OCT4, SOX2, NANOG, KLF4 and c-MYC in cancer: a review
van Schaijik B, et al. J Clin Pathol 2018 - Review. PMID 29180509
The stem cell markers octamer-binding transcription factor 4, sex-determining region Y-box 2, NANOG, Kruppel-like factor 4 and c-MYC are key factors in inducing pluripotency in somatic cells, and they have been used to detect cancer stem cell subpopulations in a range of cancer types. ...This review analyses this area of research in the context of the biology of stem cells and cancer and explores the potential modulating effect of subcellular localisation of these proteins as supported by the literature....
The stem cell markers octamer-binding transcription factor 4, sex-determining region Y-box 2, NANOG, Kruppel-like factor 4 and c-MYC …
Prohibitin 2: At a communications crossroads
Bavelloni A, et al. IUBMB Life 2015 - Review. PMID 25904163 Free article.
Prohibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators of pathologies such as cancer, neuromuscular degeneration, and other metabolic diseases. The human genome encodes two PHB proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2), which function not only as a heterodimeric complex, but also independently. ...
Prohibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs …
Introduction to NF-kappaB: players, pathways, perspectives
Gilmore TD. Oncogene 2006 - Review. PMID 17072321
Described are the structures, activities and regulation of the proteins in the NF-kappaB family of transcription factors. NF-kappaB signaling is primarily regulated by inhibitor kappaB (IkappaB) proteins and the IkappaB kinase complex through two major pathways: the canonical and non-canonical NF-kappaB pathways. ...
Described are the structures, activities and regulation of the proteins in the NF-kappaB family of transcription factors. NF-kappaB s …
The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS. Annu Rev Immunol 1996 - Review. PMID 8717528
In the nucleus, NF-kappa B dimers bind to target DNA elements and activate transcription of genes encoding proteins involved with immune or inflammation responses and with cell growth control. ...
In the nucleus, NF-kappa B dimers bind to target DNA elements and activate transcription of genes encoding proteins involved w …
Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher.
Normanno D, et al. Nat Commun 2015. PMID 26151127 Free PMC article.
Many cellular functions rely on DNA-binding proteins finding and associating to specific sites in the genome. Yet the mechanisms underlying the target search remain poorly understood, especially in the case of the highly organized mammalian cell nucleus. ...Altogether, our results provide a comprehensive view of the recruitment dynamics of proteins at specific loci in mammalian cells....
Many cellular functions rely on DNA-binding proteins finding and associating to specific sites in the genome. Yet the m …
A PDX1-ATF transcriptional complex governs β cell survival during stress
Juliana CA, et al. Mol Metab 2018. PMID 30174228 Free PMC article.
Activation of caspase 3 by immunoblotting or by irreversible binding to a fluorescent inhibitor was taken as an indication of commitment to an apoptotic fate. ...
Activation of caspase 3 by immunoblotting or by irreversible binding to a fluorescent inhibitor was taken as an indication of commitm …
Networks of Transcription Factors for Oct4 Expression in Mice
Li YQ. DNA Cell Biol 2017 - Review. PMID 28731785
Through a comprehensive analysis of the binding sites and the interrelationships of the transcription factors of Oct4, it is found that transcription factors of Oct4 form three regulating complexes centered by Oct4-Sox2, Nanog, and Lrh1. ...
Through a comprehensive analysis of the binding sites and the interrelationships of the transcription factors of Oct4, it is found th …
OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts
Narayan S, et al. Cell Rep 2017. PMID 28813671 Free PMC article.
We report that, at an early stage of reprogramming, virtually all DNA-bound OCT4, SOX2, and SOX2-VP16 were embedded in putative enhancers, about half of which were created de novo. ...Many newly created putative enhancers were transient, and many transcription factor locations on DNA changed as reprogramming progressed. ...
We report that, at an early stage of reprogramming, virtually all DNA-bound OCT4, SOX2, and SOX2-VP16 were embedded in putative enhan …
471,587 results
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