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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 3
1997 4
1998 7
1999 10
2000 8
2001 27
2002 35
2003 30
2004 36
2005 37
2006 40
2007 44
2008 45
2009 65
2010 75
2011 66
2012 65
2013 52
2014 76
2015 55
2016 49
2017 51
2018 34
2019 20
2020 1
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822 results
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Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals.
Elbadawy M, et al. Int J Mol Sci 2018 - Review. PMID 30287790 Free PMC article.
Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. ...Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. ...
Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is
Death-associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes.
Farag AK and Roh EJ. Med Res Rev 2019 - Review. PMID 29949198
Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even though a few Food and Drug Administration approved STKs inhibitors are reported. ...This family was named death-associated protein kinase family (DAPK family). DAPKs comprise five members (DAPK1, DAPK2, DAPK3, DRAK1, and DRAK2) and belong to the calcium/calmodulin-dependent kinases domain. ...
Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even though a few Food and Drug Administr …
Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.
You MH, et al. Cell Death Differ 2017. PMID 28141794 Free PMC article.
Death-associated protein kinase 1 (DAPK1) has been shown to have important roles in neuronal cell death in several model systems and has been implicated in multiple diseases, including Alzheimer's disease (AD). ...Furthermore, NDRG2-mediated cell death by DAPK1 was required for a caspase-dependent poly-ADP-ribose polymerase cleavage. In addition, DAPK1 ablation suppressed ceramide-induced cell death in mouse brain and neuronal cell death in Tg2576 APPswe-overexpressing mice. ...
Death-associated protein kinase 1 (DAPK1) has been shown to have important roles in neuronal cell death in sever
Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease.
Kim N, et al. Int J Mol Sci 2019 - Review. PMID 31248062 Free PMC article.
Regulated neuronal cell death plays an essential role in biological processes in normal physiology, including the development of the nervous system. ...Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin (Ca(2+)/CaM)-dependent serine/threonine (Ser/Thr) protein kinase that activates death signaling and regulates apoptotic neuronal cell death. ...
Regulated neuronal cell death plays an essential role in biological processes in normal physiology, including the development of the …
Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression.
Chou TF, et al. Nat Commun 2016. PMID 27312851 Free PMC article.
Death-associated protein kinase (DAPK) is a tumour suppressor. Here we show that DAPK also inhibits T helper 17 (Th17) and prevents Th17-mediated pathology in a mouse model of autoimmunity. ...DAPK also binds prolyl hydroxylase domain protein 2 (PHD2) and increases HIF-1α-PHD2 association. DAPK thereby promotes the proline hydroxylation and proteasome degradation of HIF-1α. ...
Death-associated protein kinase (DAPK) is a tumour suppressor. Here we show that DAPK also inhibits T helper 17 (Th17)
Death-associated protein kinase 2: Regulator of apoptosis, autophagy and inflammation.
Geering B. Int J Biochem Cell Biol 2015 - Review. PMID 26055515
Death-associated protein kinase 2 (DAPK2/DRP-1) belongs to a family of five related serine/threonine kinases that mediate a range of cellular processes, including membrane blebbing, apoptosis, and autophagy, and possess tumour suppressive functions. ...
Death-associated protein kinase 2 (DAPK2/DRP-1) belongs to a family of five related serine/threonine kinases tha
Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer's Disease.
Chen D, et al. Recent Pat Anticancer Drug Discov 2019 - Review. PMID 30569876 Free PMC article.
BACKGROUND: Death-Associated Protein Kinase 1 (DAPK1) plays an important role in apoptosis, tumor suppression and neurodegeneration including Alzheimer's Disease (AD). ...It is down-regulated and/or inactivated by multiple mechanisms in many human cancers, and elicits a protective effect to counteract numerous death stimuli in cancer, including activation of the master regulator Pin1. ...
BACKGROUND: Death-Associated Protein Kinase 1 (DAPK1) plays an important role in apoptosis, tumor suppression and neuro …
Death associated protein kinases: molecular structure and brain injury.
Nair S, et al. Int J Mol Sci 2013 - Review. PMID 23880846 Free PMC article.
A member of the death associated protein kinase (DAPk) family, DAPk1, has been implicated in cerebral ischemic damage, whereby DAPk1 potentiates NMDA receptor-mediated excitotoxicity through interaction with the NR2BR subunit. DAPk1 also mediate a range of activities from autophagy, membrane blebbing and DNA fragmentation ultimately leading to cell death. ...
A member of the death associated protein kinase (DAPk) family, DAPk1, has been implicated in cerebral ischemic damage, …
Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
Zhao J, et al. J Clin Invest 2015. PMID 26075823 Free PMC article.
Estrogen receptor-negative (ER-negative) breast cancers are extremely aggressive and associated with poor prognosis. In particular, effective treatment strategies are limited for patients diagnosed with triple receptor-negative breast cancer (TNBC), which also carries the worst prognosis of all forms of breast cancer; therefore, extensive studies have focused on the identification of molecularly targeted therapies for this tumor subtype. ...Specifically, we found that death-associated protein kinase 1 (DAPK1) is essential for growth of p53-mutant cancers, which account for over 80% of TNBCs. ...
Estrogen receptor-negative (ER-negative) breast cancers are extremely aggressive and associated with poor prognosis. In particular, e …
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