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Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
Luk CT, Chan CK, Chiu F, Shi SY, Misra PS, Li YZ, Pollock-Tahiri E, Schroer SA, Desai HR, Sivasubramaniyam T, Cai EP, Krishnamurthy M, Han DJ, Chowdhury A, Aslam R, Yuen DA, Hakem A, Hakem R, Woo M. Luk CT, et al. Diabetes. 2023 Dec 1;72(12):1751-1765. doi: 10.2337/db22-1033. Diabetes. 2023. PMID: 37699387
Knockout mice also gained less weight on HFD, with decreased adiposity, adipocyte size, and hepatic steatosis. These mice had decreased adipose tissue inflammation and decreased activation of canonical and noncanonical NF-kappaB signaling. ...
Knockout mice also gained less weight on HFD, with decreased adiposity, adipocyte size, and hepatic steatosis. These mice had decreased …
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity.
Cifarelli V, Beeman SC, Smith GI, Yoshino J, Morozov D, Beals JW, Kayser BD, Watrous JD, Jain M, Patterson BW, Klein S. Cifarelli V, et al. J Clin Invest. 2020 Dec 1;130(12):6688-6699. doi: 10.1172/JCI141828. J Clin Invest. 2020. PMID: 33164985 Free PMC article. Clinical Trial.
BACKGROUNDData from studies conducted in rodent models have shown that decreased adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin resistance. ...Plasma PAI-1 increased from the MHL to the MHO to the MUO group and was …
BACKGROUNDData from studies conducted in rodent models have shown that decreased adipose tissue (AT) oxygenation is inv …
Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes.
Kovacova Z, Tharp WG, Liu D, Wei W, Xie H, Collins S, Pratley RE. Kovacova Z, et al. Obesity (Silver Spring). 2016 Apr;24(4):820-8. doi: 10.1002/oby.21418. Epub 2016 Feb 17. Obesity (Silver Spring). 2016. PMID: 26887289 Free PMC article. Clinical Trial.
METHODS: A cross-sectional study of subjects with a wide range of BMI and glucose tolerance (n = 50) was conducted, as well as a randomized 12-week trial of subjects with type 2 diabetes mellitus (T2DM) treated with pioglitazone (n = 9) or placebo (n = 10). ...Treat …
METHODS: A cross-sectional study of subjects with a wide range of BMI and glucose tolerance (n = 50) was conducted, as well as a randomiz …
Complex Positive Effects of SGLT-2 Inhibitor Empagliflozin in the Liver, Kidney and Adipose Tissue of Hereditary Hypertriglyceridemic Rats: Possible Contribution of Attenuation of Cell Senescence and Oxidative Stress.
Trnovska J, Svoboda P, Pelantova H, Kuzma M, Kratochvilova H, Kasperova BJ, Dvorakova I, Rosolova K, Malinska H, Huttl M, Markova I, Oliyarnyk O, Melcova M, Skop V, Mraz M, Stemberkova-Hubackova S, Haluzik M. Trnovska J, et al. Int J Mol Sci. 2021 Sep 30;22(19):10606. doi: 10.3390/ijms221910606. Int J Mol Sci. 2021. PMID: 34638943 Free PMC article.
Nuclear magnetic resonance (NMR)-based metabolomics; quantitative PCR of relevant genes involved in lipid and glucose metabolism, or senescence; glucose and palmitic acid oxidation in isolated tissues and cell lines of adipocytes and hepatocytes were used. (3) Results: empagliflo …
Nuclear magnetic resonance (NMR)-based metabolomics; quantitative PCR of relevant genes involved in lipid and glucose metabolism, or senesce …
IL-15 concentrations in skeletal muscle and subcutaneous adipose tissue in lean and obese humans: local effects of IL-15 on adipose tissue lipolysis.
Pierce JR, Maples JM, Hickner RC. Pierce JR, et al. Am J Physiol Endocrinol Metab. 2015 Jun 15;308(12):E1131-9. doi: 10.1152/ajpendo.00575.2014. Epub 2015 Apr 28. Am J Physiol Endocrinol Metab. 2015. PMID: 25921578 Free PMC article. Clinical Trial.
Animal/cell investigations indicate that there is a decreased adipose tissue mass resulting from skeletal muscle (SkM) IL-15 secretion (e.g., SkM-blood-adipose tissue axis). ...
Animal/cell investigations indicate that there is a decreased adipose tissue mass resulting from skeletal muscle (SkM) …
Combined Insulin Deficiency and Endotoxin Exposure Stimulate Lipid Mobilization and Alter Adipose Tissue Signaling in an Experimental Model of Ketoacidosis in Subjects With Type 1 Diabetes: A Randomized Controlled Crossover Trial.
Svart M, Kampmann U, Voss T, Pedersen SB, Johannsen M, Rittig N, Poulsen PL, Nielsen TS, Jessen N, Møller N. Svart M, et al. Diabetes. 2016 May;65(5):1380-6. doi: 10.2337/db15-1645. Epub 2016 Feb 16. Diabetes. 2016. PMID: 26884439 Clinical Trial.
During KET, serum tumor necrosis factor-alpha, cortisol, glucagon, and growth hormone levels increased, and free fatty acids and 3-hydroxybutyrate concentrations and the rate of lipolysis rose markedly. Serum bicarbonate and pH decreased. Adipose tissue mRNA …
During KET, serum tumor necrosis factor-alpha, cortisol, glucagon, and growth hormone levels increased, and free fatty acids and 3-hydroxybu …
Rosiglitazone treatment increases subcutaneous adipose tissue glucose uptake in parallel with perfusion in patients with type 2 diabetes: a double-blind, randomized study with metformin.
Viljanen AP, Virtanen KA, Järvisalo MJ, Hällsten K, Parkkola R, Rönnemaa T, Lönnqvist F, Iozzo P, Ferrannini E, Nuutila P. Viljanen AP, et al. J Clin Endocrinol Metab. 2005 Dec;90(12):6523-8. doi: 10.1210/jc.2005-1073. Epub 2005 Sep 27. J Clin Endocrinol Metab. 2005. PMID: 16189256 Clinical Trial.
PATIENTS: Thirty-seven patients with newly diagnosed type 2 diabetes were included. INTERVENTION: Patients were randomized into treatment with rosiglitazone, metformin, or placebo for 26 wk in a double-blinded trial. ...Rosiglitazone treatment increased flow by 72% …
PATIENTS: Thirty-seven patients with newly diagnosed type 2 diabetes were included. INTERVENTION: Patients were randomized into treat …
The anti-angiogenic herbal extract from Melissa officinalis inhibits adipogenesis in 3T3-L1 adipocytes and suppresses adipocyte hypertrophy in high fat diet-induced obese C57BL/6J mice.
Woo S, Yoon M, Kim J, Hong Y, Kim MY, Shin SS, Yoon M. Woo S, et al. J Ethnopharmacol. 2016 Feb 3;178:238-50. doi: 10.1016/j.jep.2015.12.015. Epub 2015 Dec 15. J Ethnopharmacol. 2016. PMID: 26702505
An in vivo study showed that ALS-L1023 not only decreased adipose tissue mass and adipocyte size, but also reduced mRNA levels of adipose tissue angiogenic factors and MMPs in HFD-fed obese mice. ...
An in vivo study showed that ALS-L1023 not only decreased adipose tissue mass and adipocyte size, but also reduced mRNA …
Effect of improved diabetes control on the expression of lipoprotein lipase in human adipose tissue.
Simsolo RB, Ong JM, Saffari B, Kern PA. Simsolo RB, et al. J Lipid Res. 1992 Jan;33(1):89-95. J Lipid Res. 1992. PMID: 1552236 Free article.
Patients with diabetes commonly manifest hypertriglyceridemia along with decreased adipose tissue lipoprotein lipase (LPL) activity, and improved diabetes control tends to reverse these abnormalities. ...
Patients with diabetes commonly manifest hypertriglyceridemia along with decreased adipose tissue lipoprotein lipase (L …
The IGF-I response to very low rhGH doses is preserved in human ageing.
Arvat E, Ceda G, Ramunni J, Lanfranco F, Aimaretti G, Gianotti L, Broglio F, Ghigo E. Arvat E, et al. Clin Endocrinol (Oxf). 1998 Dec;49(6):757-63. doi: 10.1046/j.1365-2265.1998.00613.x. Clin Endocrinol (Oxf). 1998. PMID: 10209563
In fact, treatment with pharmacological doses of rhGH restored plasma IGF-I levels, increased lean body mass and muscle strength while decreased adipose tissue mass in healthy elderly subjects. At present it is unclear whether peripheral GH sensitivity is pre …
In fact, treatment with pharmacological doses of rhGH restored plasma IGF-I levels, increased lean body mass and muscle strength while de …