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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 2
1965 76
1966 135
1967 145
1968 130
1969 133
1970 139
1971 158
1972 150
1973 133
1974 138
1975 133
1976 156
1977 158
1978 178
1979 175
1980 110
1981 48
1982 35
1983 43
1984 37
1985 25
1986 28
1987 28
1988 27
1989 33
1990 29
1991 33
1992 29
1993 34
1994 50
1995 62
1996 66
1997 78
1998 89
1999 94
2000 164
2001 119
2002 124
2003 140
2004 206
2005 208
2006 252
2007 263
2008 273
2009 299
2010 357
2011 418
2012 432
2013 435
2014 463
2015 470
2016 461
2017 445
2018 469
2019 236
2020 1
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8,537 results
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Page 1
Pharmacotherapy for Perinatal Depression.
Lusskin SI, et al. Clin Obstet Gynecol 2018 - Review. PMID 29561284
Perinatal depression is associated with serious risks for the mother, baby, and family. When considering treating perinatal depression with a drug indicated for the treatment of depression, the major concerns are whether the drug increases the risks of teratogenicity, pregnancy complications, poor neonatal adaptation, or neurodevelopmental disorders. Although different studies have produced different results, the majority have not shown increases in risk for selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, tricyclic antidepressants, or the noradrenergic/dopaminergic drug bupropion. ...
Perinatal depression is associated with serious risks for the mother, baby, and family. When considering treating perinatal depres
How do antidepressants work? New perspectives for refining future treatment approaches
Harmer CJ, et al. Lancet Psychiatry 2017 - Review. PMID 28153641 Free PMC article.
However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. ...
However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of mo …
Oral Ketamine for Depression, 1: Pharmacologic Considerations and Clinical Evidence.
Andrade C. J Clin Psychiatry 2019 - Review. PMID 30946543 Free article.
Case reports, case series, chart reviews, and 3 recent randomized controlled trials (RCTs) show that oral ketamine is effective in treating severe depression, depression with suicidal ideation, and treatment-resistant depression; that oral ketamine, used as an augmentation agent, improves outcomes in patients receiving a conventional antidepressant; and that oral ketamine reduces depression in patients with chronic pain. ...These findings suggest that if ketamine is to find a place as an off-label treatment for depression and suicidality in mainstream psychiatry, researchers should study the safety, efficacy, and optimization of oral ketamine. ...
Case reports, case series, chart reviews, and 3 recent randomized controlled trials (RCTs) show that oral ketamine is effective in treating …
Peripheral administration of lactate produces antidepressant-like effects
Carrard A, et al. Mol Psychiatry 2018. PMID 27752076 Free PMC article.
Clinical and basic research studies have shown that major depression and chronic stress are associated with alterations in structural and functional plasticity. ...Further elucidation of the mechanisms underlying the antidepressant effects of l-lactate may help to identify novel therapeutic targets for the treatment of depression....
Clinical and basic research studies have shown that major depression and chronic stress are associated with alterations in structural …
Predictors of Response and Remission to Antidepressants in Geriatric Depression: A Systematic Review.
Masse-Sibille C, et al. J Geriatr Psychiatry Neurol 2018. PMID 30477416
The results of our review confirm that geriatric depression includes many subgroups of patients with particular endophenotypes that may influence the course of depression. CONCLUSION: Further studies are needed to characterize depression subgroups in order to better understand the pathophysiology of late life depression and to find specific predictors for each group of patients....
The results of our review confirm that geriatric depression includes many subgroups of patients with particular endophenotypes that m …
Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials.
Sun Y, et al. BMC Complement Altern Med 2018 - Review. PMID 29454341 Free PMC article.
BACKGROUND: Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. ...CONCLUSIONS: This review found that Chai Hu Shu Gan San has some advantages in treating depression, especially post-stroke depression and post-partum depression. ...
BACKGROUND: Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depressi
Depression in adults: drug and physical treatments.
Cipriani A, et al. BMJ Clin Evid 2011 - Review. PMID 21609510 Free PMC article.
In severe depression, only prescription antidepressants and electroconvulsive therapy are known to improve symptoms. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments in mild to moderate and severe depression, and in treatment-resistant depression? ...We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). ...
In severe depression, only prescription antidepressants and electroconvulsive therapy are known to improve symptoms. METHODS A …
Present status of drug therapy of depression in late life.
Gerner RH. J Affect Disord 1985 - Review. PMID 2869075
The increasing proportion of elderly to the general population and the relatively high prevalence rate of depression in this age group justifies concern for specific clinical indications for antidepressant selection. ...
The increasing proportion of elderly to the general population and the relatively high prevalence rate of depression in this age grou …
New Treatment Options for Depression: A Primer for Internists.
Byun TH, et al. Am J Med 2019 - Review. PMID 30710538
Depression continues to be a challenging condition to treat despite the myriad treatment options available. Primary care providers are increasingly tasked with providing second- and third-line treatments for major depressive disorder, and thus, should be familiar with newer medication therapies that are available. In this article, we aim to provide the general internist and other providers who treat depression in their practice with a succinct review of recent developments in the treatment of depression....
Depression continues to be a challenging condition to treat despite the myriad treatment options available. Primary care providers ar
[Drug therapy of masked depression].
Kielholz P and Adams C. Dtsch Med Wochenschr 1979. PMID 33789 German.
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