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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1953 4
1954 6
1955 11
1956 17
1957 9
1958 12
1959 15
1960 7
1961 12
1962 7
1964 1
1965 30
1966 62
1967 118
1968 161
1969 179
1970 191
1971 230
1972 238
1973 256
1974 298
1975 322
1976 316
1977 257
1978 245
1979 241
1980 185
1981 148
1982 145
1983 125
1984 129
1985 135
1986 191
1987 170
1988 178
1989 171
1990 174
1991 199
1992 174
1993 196
1994 216
1995 205
1996 300
1997 377
1998 428
1999 526
2000 540
2001 573
2002 589
2003 769
2004 844
2005 1004
2006 1058
2007 1131
2008 1297
2009 1479
2010 1730
2011 2001
2012 2187
2013 2368
2014 2434
2015 2352
2016 2391
2017 2278
2018 2160
2019 960
2020 8
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Search Results

33,513 results
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Page 1
The molecular neurobiology of depression.
Krishnan V and Nestler EJ. Nature 2008 - Review. PMID 18923511 Free PMC article.
Nevertheless, other symptoms have been accurately modelled, and these, together with clinical data, are providing insight into the neurobiology of depression. Recent studies combining behavioural, molecular and electrophysiological techniques reveal that certain aspects of depression result from maladaptive stress-induced neuroplastic changes in specific neural circuits. ...
Nevertheless, other symptoms have been accurately modelled, and these, together with clinical data, are providing insight into the neurobiol …
Depression in Autoimmune Diseases.
Pryce CR and Fontana A. Curr Top Behav Neurosci 2017 - Review. PMID 27221625 Free article.
Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. ...
Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like sympt …
Depression and Sleep.
Steiger A and Pawlowski M. Int J Mol Sci 2019 - Review. PMID 30708948 Free PMC article.
Impaired sleep is both a risk factor and a symptom of depression. Objective sleep is assessed using the sleep electroencephalogram (EEG). ...Some predictive sleep-EEG markers of depression appear to be related to hypothalamo-pituitary-adrenocortical system activity....
Impaired sleep is both a risk factor and a symptom of depression. Objective sleep is assessed using the sleep electroencephalogram (E …
[Inflammatory mechanism of depression and its new strategy for diagnosis and treatment].
Su WJ, et al. Sheng Li Xue Bao 2017 - Review. PMID 29063119 Chinese. Free article.
Depression is a major class of mental illness; owing to its high prevalence, high disability rate and heavy disease burden, it has become a stern and formidable global health problem. It is generally believed that the etiology of depression is multifactorial, which is related to gender differences, chronic stress, dietary behavior and drug abuse. ...
Depression is a major class of mental illness; owing to its high prevalence, high disability rate and heavy disease burden, it has be
Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress.
Jianguo L, et al. Transl Psychiatry 2019. PMID 30696813 Free PMC article.
In addition, metabolic disorder, which is strongly associated with depression, is exacerbated by changes in the composition of the gut microbiota and is alleviated by treatment with antidepressants. However, the key players and pathways that link the gut microbiota to the pathogenesis of depression remain largely unknown. ...
In addition, metabolic disorder, which is strongly associated with depression, is exacerbated by changes in the composition of the gu …
Pharmacological management of depression in patients with multiple sclerosis.
Carta MG, et al. Expert Opin Pharmacother 2018 - Review. PMID 30207800
INTRODUCTION: The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. ...AREAS COVERED: This review provides a clinically oriented critical perspective on the connection between MS and major depressive disorder (MDD) or depression associated with bipolar disorder (BD), focusing on its optimal pharmacotherapy. ...
INTRODUCTION: The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that ca …
Understanding the epigenetic basis of sex differences in depression.
Hodes GE, et al. J Neurosci Res 2017 - Review. PMID 27870456 Free PMC article.
Depression is twofold more common in females, yet the majority of preclinical research has been conducted exclusively in male subjects. Here we discuss what is known about sex differences in epigenetic regulation and function and how this may contribute to the etiology and onset of mood disorders. © 2016 Wiley Periodicals, Inc....
Depression is twofold more common in females, yet the majority of preclinical research has been conducted exclusively in male subject
[Gut microbiota and depressive symptoms]
Knudsen JK, et al. Ugeskr Laeger 2017 - Review. PMID 29208194 Danish.
The gut microbiota is believed to affect a wide variety of mental disorders, including depression. The hypothesis involves bacterial signalling to the host through metabolic, endocrinal, immunologic and neuronal pathways. Few studies of patients with depression have shown altered microbiota profiles and increased levels of systemic endotoxin, which can be detected by leucocytes and result in expression of cytokines. ...
The gut microbiota is believed to affect a wide variety of mental disorders, including depression. The hypothesis involves bacterial …
The role of CREB and other transcription factors in the pharmacotherapy and etiology of depression.
Sulser F. Ann Med 2002 - Review. PMID 12452479
Since transcription factors represent the final communicative link between receptor activation and the orchestration of programs of gene expression, they are prime targets for studies on both the pharmacotherapy and the etiology of depression. ...Moreover, pCREB is down-regulated in human fibroblasts from patients with major depression and in postmortem brain of suicide victims with a history of depression. ...
Since transcription factors represent the final communicative link between receptor activation and the orchestration of programs of gene exp …
A network perspective on comorbid depression in adolescents with obsessive-compulsive disorder.
Jones PJ, et al. J Anxiety Disord 2018. PMID 29125957
Models showed OCD and depression as separate syndromes linked by bridge symptoms. Bridges between the two disorders emerged between obsessional problems in the OCD syndrome, and guilt, concentration problems, and sadness in the depression syndrome. ...We conclude that the network approach to mental disorders provides a new way to understand the etiology and maintenance of comorbid OCD-depression. ...
Models showed OCD and depression as separate syndromes linked by bridge symptoms. Bridges between the two disorders emerged between o …
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