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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 1
1957 1
1959 4
1960 4
1962 2
1965 6
1966 16
1967 26
1968 41
1969 45
1970 54
1971 61
1972 58
1973 70
1974 103
1975 91
1976 82
1977 105
1978 117
1979 109
1980 120
1981 33
1982 30
1983 21
1984 28
1985 18
1986 45
1987 25
1988 36
1989 37
1990 33
1991 35
1992 32
1993 42
1994 35
1995 32
1996 35
1997 45
1998 71
1999 71
2000 74
2001 91
2002 86
2003 113
2004 111
2005 137
2006 157
2007 202
2008 216
2009 282
2010 328
2011 394
2012 458
2013 504
2014 483
2015 582
2016 637
2017 649
2018 613
2019 265
2020 0
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7,153 results
Results by year
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Page 1
Neurobiology of depression.
Nestler EJ, et al. Neuron 2002 - Review. PMID 11931738 Free article.
Current treatments for depression are inadequate for many individuals, and progress in understanding the neurobiology of depression is slow. ...These advances will fundamentally improve the treatment and prevention of depression....
Current treatments for depression are inadequate for many individuals, and progress in understanding the neurobiology of depressio
MicroRNAs and exosomes in depression: Potential diagnostic biomarkers.
Tavakolizadeh J, et al. J Cell Biochem 2018 - Review. PMID 29236313
Hence, miRNAs could be used as diagnostic and therapeutic biomarkers in patients with depression. Besides miRNAs, exosomes as nano- carriers could have been emerged as diagnostic biomarkers in several diseases such as depression. ...Moreover, we highlighted exosomes as new diagnostic biomarkers for patients with depression....
Hence, miRNAs could be used as diagnostic and therapeutic biomarkers in patients with depression. Besides miRNAs, exosomes as nano- c …
Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis.
Leighton SP, et al. Mol Psychiatry 2018 - Review. PMID 29133955 Free PMC article.
Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral-central crosstalk and may be important in mediating depressive behaviours. ...Overall, our meta-analysis finds evidence linking abnormalities of blood chemokines with depression in humans. Furthermore, we have demonstrated the possibility of classifying individuals with depression based on their inflammatory biomarker profile. ...
Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral-central cro …
Sex differences in depression during pregnancy and the postpartum period.
Sundström Poromaa I, et al. J Neurosci Res 2017 - Review. PMID 27870443 Free PMC article.
This Review discusses the literature on maternal and paternal depression and the endocrine changes that may predispose a person to depression at this stage of life, with specific focus on the hypothalamus-pituitary axis, oxytocin, and testosterone levels in men. ...Additionally, sex differences in neurogenesis and brain plasticity are described in relation to peripartum depression. © 2016 The Authors. ...
This Review discusses the literature on maternal and paternal depression and the endocrine changes that may predispose a person to …
Molecular aspects of depression: A review from neurobiology to treatment.
Villas Boas GR, et al. Eur J Pharmacol 2019 - Review. PMID 30776369
Major depressive disorder (MDD), also known as unipolar depression, is one of the leading causes of disability and disease worldwide. ...
Major depressive disorder (MDD), also known as unipolar depression, is one of the leading causes of disability and disease worldwide. …
Ceramides and depression: A systematic review.
Dinoff A, et al. J Affect Disord 2017 - Review. PMID 28189963
Aberrant sphingolipid metabolism has been observed in some cases of depression, specifically alterations in ceramide concentrations. ...Evidence for altered ceramide metabolism in depression is present, but data for a causal role of ceramides in depression are lacking. ...
Aberrant sphingolipid metabolism has been observed in some cases of depression, specifically alterations in ceramide concentra …
The ERK Pathway: Molecular Mechanisms and Treatment of Depression.
Wang JQ and Mao L. Mol Neurobiol 2019 - Review. PMID 30737641 Free PMC article.
In humans and various chronic animal models of depression, the ERK signaling was significantly downregulated in the prefrontal cortex and hippocampus, two core areas implicated in depression. ...Thus, ERK signaling in the depression-implicated brain regions was disrupted during the development of depression, which contributes to the long-lasting and transcription-dependent neuroadaptations critical for enduring depression-like behavior and the therapeutic effect of antidepressants....
In humans and various chronic animal models of depression, the ERK signaling was significantly downregulated in the prefrontal cortex …
Kynurenine pathway in depression: A systematic review and meta-analysis.
Ogyu K, et al. Neurosci Biobehav Rev 2018. PMID 29608993
Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression. However, the relationships between depression and each metabolite of the KYN pathway remain uncertain. Therefore, we conducted a meta-analysis about the levels of the metabolites of KYN pathway between patients with depression and controls. ...
Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression. However, the relationships betw …
The role of allopregnanolone in depression and anxiety.
Schüle C, et al. Prog Neurobiol 2014 - Review. PMID 24215796
Reduced levels of allopregnanolone in the peripheral blood or cerebrospinal fluid were found to be associated with major depression, anxiety disorders, premenstrual dysphoric disorder, negative symptoms in schizophrenia, or impulsive aggression. ...Until now synthetic neuroactive steroids could not be established in the treatment of anxiety disorders or depression. However, the translocator protein (18 kDa) (TSPO) which is important for neurosteroidogenesis has been identified as a potential novel target. ...
Reduced levels of allopregnanolone in the peripheral blood or cerebrospinal fluid were found to be associated with major depression, …
The many faces of CREB
Carlezon WA, et al. Trends Neurosci 2005 - Review. PMID 15982754
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