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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 2
1966 1
1980 1
1983 3
1985 2
1986 5
1987 2
1988 7
1989 5
1990 5
1991 6
1992 5
1993 4
1994 3
1995 1
1996 3
1997 11
1998 8
1999 7
2000 20
2001 15
2002 23
2003 16
2004 18
2005 31
2006 25
2007 39
2008 46
2009 75
2010 119
2011 123
2012 125
2013 111
2014 141
2015 136
2016 107
2017 94
2018 81
2019 38
2020 0
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1,200 results
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Page 1
An astroglial basis of major depressive disorder? An overview.
Wang Q, et al. Glia 2017 - Review. PMID 28317185
Mounting evidence from clinical, preclinical and post-mortem studies has revealed a decrease in the number or density of astrocytes and morphological and functional astroglial atrophy in patients with major depressive disorder (MDD) and in animal models of depression. ...More importantly, dysfunctional astrocytes lead to depressive-like phenotypes in animals. Together, current studies point to astroglial pathology as the potential root cause of MDD. ...
Mounting evidence from clinical, preclinical and post-mortem studies has revealed a decrease in the number or density of astrocytes and morp …
Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue.
Rajkowska G and Stockmeier CA. Curr Drug Targets 2013 - Review. PMID 23469922 Free PMC article.
The present paper reviews astrocyte pathology in major depressive disorder (MDD) and proposes that reductions in astrocytes and related markers are key features in the pathology of MDD. ...Pathology of astrocytes has been consistently noted in MDD as well as in rodent models of depressive-like behavior. This review summarizes evidence from human postmortem tissue showing alterations in the expression of protein and mRNA for astrocyte markers such as glial fibrillary acidic protein (GFAP), gap junction proteins (connexin 40 and 43), the water channel aquaporin-4 (AQP4), a calcium-binding protein S100B and glutamatergic markers including the excitatory amino acid transporters 1 and 2 (EAAT1, EAAT2) and glutamine synthetase. ...
The present paper reviews astrocyte pathology in major depressive disorder (MDD) and proposes that reductions in astroc …
Resting-state functional connectivity in major depressive disorder: A review.
Mulders PC, et al. Neurosci Biobehav Rev 2015 - Review. PMID 26234819
Major depressive disorder (MDD) affects multiple large-scale functional networks in the brain, which has initiated a large number of studies on resting-state functional connectivity in depression. ...These findings correspond to the current understanding of depression as a network-based disorder....
Major depressive disorder (MDD) affects multiple large-scale functional networks in the brain, which has initiated a large num …
Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder.
Bromis K, et al. Am J Psychiatry 2018. PMID 30021460 Free PMC article.
The region-of-interest meta-analysis was conducted and compared with a meta-analysis of major depressive disorder. Within the region-of-interest meta-analysis, three subanalyses were conducted that included control groups with and without trauma. ...Compared with region-of-interest data from patients with major depressive disorder, those with PTSD had reduced total brain volume, and both disorders were associated with reduced hippocampal volume. ...
The region-of-interest meta-analysis was conducted and compared with a meta-analysis of major depressive disorder. Within the …
Hippocampal neuroplasticity in major depressive disorder.
Malykhin NV and Coupland NJ. Neuroscience 2015 - Review. PMID 25934030
One of the most replicated findings has been that hippocampus volume is decreased in patients with major depressive disorder (MDD). ...
One of the most replicated findings has been that hippocampus volume is decreased in patients with major depressive disorder ( …
Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group.
Schmaal L, et al. Mol Psychiatry 2016. PMID 26122586 Free PMC article.
The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. ...
The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in par …
Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group.
Schmaal L, et al. Mol Psychiatry 2017. PMID 27137745 Free PMC article.
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. ...
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging st …
Longitudinal brain volume changes in major depressive disorder.
Yüksel D, et al. J Neural Transm (Vienna) 2018. PMID 30167933
Patients with major depressive disorder (MDD) exhibit gray matter volume (GMV) reductions in limbic regions. Clinical variables-such as the number of depressive episodes-seem to affect volume alterations. ...Further analyses comparing patients with a mild course of disorder (MCD; 0-1 depressive episode during the follow-up) to patients with a severe course of disorder (SCD; > 1 depressive episode during the follow-up) revealed increasing amygdalar volume in MCD. ...
Patients with major depressive disorder (MDD) exhibit gray matter volume (GMV) reductions in limbic regions. Clinical variable …
Hippocampal subfield volumes in major depressive disorder and bipolar disorder.
Han KM, et al. Eur Psychiatry 2019. PMID 30721801
Few studies have explored hippocampal subfield volume difference in the same sample of major depressive disorder (MDD) and bipolar disorder (BD) cases. ...
Few studies have explored hippocampal subfield volume difference in the same sample of major depressive disorder (MDD) and bip …
Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease
Baker JD, et al. Int J Mol Sci 2018 - Review. PMID 30585227 Free PMC article.
There is strong evidence suggesting altered regulation of steroid receptor hormones by chaperones, particularly the 51 kDa FK506-binding protein (FKBP51), may work with environmental factors to increase susceptibility to various psychiatric illnesses including post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety. ...
There is strong evidence suggesting altered regulation of steroid receptor hormones by chaperones, particularly the 51 kDa FK506-binding pro …
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