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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 9
1965 41
1966 89
1967 99
1968 116
1969 122
1970 113
1971 105
1972 116
1973 94
1974 122
1975 101
1976 74
1977 137
1978 214
1979 234
1980 244
1981 278
1982 316
1983 331
1984 339
1985 368
1986 362
1987 356
1988 442
1989 447
1990 451
1991 430
1992 489
1993 428
1994 449
1995 425
1996 388
1997 411
1998 352
1999 415
2000 414
2001 409
2002 425
2003 449
2004 528
2005 612
2006 672
2007 612
2008 672
2009 750
2010 815
2011 890
2012 1018
2013 1117
2014 1075
2015 1129
2016 1120
2017 1086
2018 1172
2019 516
2020 2
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23,151 results
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Page 1
Strategies for preclinical pharmacokinetic investigation in streptozotocin-induced diabetes mellitus (DMIS) and alloxan-induced diabetes mellitus (DMIA) rat models: case studies and perspectives.
Srinivas NR. Eur J Drug Metab Pharmacokinet 2015 - Review. PMID 24596068
Preclinical rodent models that manifest type 2 diatetes mellitus using either streptozotocin (DMIS) or alloxan (DMIA) have been well established. Both DMIS and DMIA models have served as key experimental tools to evaluate and understand the pharmacokinetic disposition of scores of drugs and therefore some key questions with respect to absorption, metabolism or elimination of drugs can be answered during the development of full-blown diabetes in the animal models. ...
Preclinical rodent models that manifest type 2 diatetes mellitus using either streptozotocin (DMIS) or alloxan (DMIA) have been well …
The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications.
Haluzík M and Nedvídková J. Physiol Res 2000 - Review. PMID 10984070 Free article.
The overproduction of NO during the development of streptozotocin-induced diabetes is probably an important part of the complex autoimmune reaction which leads to the destruction of pancreatic beta-cells. Further clarification of the role of nitric oxide in streptozotocin-induced diabetes development could have important clinical implications....
The overproduction of NO during the development of streptozotocin-induced diabetes is probably an important part of the complex autoi …
1H NMR-based metabolomics approach to investigating the renal protective effects of Genipin in diabetic rats
Tian JS, et al. Chin J Nat Med 2018. PMID 29703326
Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studies have revealed that genipin can not only improve diabetes, but also induce cytotoxicity. ...They were mainly related to three metabolic pathways: synthesis and degradation of ketone bodies, glycine, serine and threonine metabolism, and butanoate metabolism, which are involved in methylamine metabolism, energy metabolism and amino acid metabolism. ...
Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studie …
Proteomic Study on the New Potential Mechanism and Biomarkers of Diabetes.
Wang N, et al. Proteomics Clin Appl 2019. PMID 30035378
PURPOSE: Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. So far, the pathogenesis of diabetes has not been fully elucidated. ...EXPERIMENTAL DESIGN: Proteomic changes in the liver of type 2 diabetic mice (n = 6) and normal mice (n = 6) are studied. Triplicate experiments are carried out for each sample. ...
PURPOSE: Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. So far, the pathogenesis of diabe
The application of post-translational modification oriented serum proteomics to assess experimental diabetes with complications.
Chen HM, et al. PLoS One 2018. PMID 30395577 Free PMC article.
To circumvent the principal barrier of serum proteomics, our investigation aimed to evaluate whether a study of post-translational modification enriched serum proteins could be valuable for the discovery of biomarkers or metabolic pathways related to type 2 diabetes pathogenesis. ...Our results also indicated the potential association of the hepatic secretome and hepatocyte nuclear factors in the pathogenesis of type 2 diabetes and its complications....
To circumvent the principal barrier of serum proteomics, our investigation aimed to evaluate whether a study of post-translational modificat …
Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats.
Rocha DS, et al. Biomed Pharmacother 2018. PMID 29864625
The relationship between metabolic disturbances and clinical events related to diabetes is well known. Yerba mate has presented a potential use as preventive and therapeutic agent on diabetes. The aim of this study was to evaluate the effect of yerba mate on different tissues of diabetic rats, focusing on energetic metabolism. ...
The relationship between metabolic disturbances and clinical events related to diabetes is well known. Yerba mate has presented a pot …
Metabolomics analysis of alloxan-induced diabetes in mice using UPLC-Q-TOF-MS after Crassostrea gigas polysaccharide treatment.
Zhao G, et al. Int J Biol Macromol 2018. PMID 29233709
Nineteen metabolites in urine such as l-carnitine, hippuric acid, pantothenate and ornithine were selected as potential therapeutic biomarkers and related metabolic pathways of CGPS for treating diabetes. They were mainly involved in amino acid metabolism, carbohydrate metabolism and purine metabolism. These data suggested that CGPS has antidiabetic activity and urine metabolites provided new understanding of CGPS for treating diabetes and its complications....
Nineteen metabolites in urine such as l-carnitine, hippuric acid, pantothenate and ornithine were selected as potential therapeutic biomarke …
Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing
Kesherwani V, et al. PLoS One 2017. PMID 28837672 Free PMC article.
Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly understood. ...
Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the underlying molecular mechanisms for d …
Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model
Sas KM, et al. J Lipid Res 2018. PMID 29237716 Free PMC article.
Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications from multiple diseases, including type 2 diabetes. ...Using a mouse model of type 2 diabetes with microvascular complications, we examined lipid levels in plasma and in renal, neural, and retinal tissues to identify shared and distinct lipid abnormalities. ...
Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications fro …
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