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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1972 1
1980 2
1981 1
1982 12
1983 92
1984 251
1985 274
1986 319
1987 360
1988 461
1989 431
1990 497
1991 505
1992 516
1993 683
1994 637
1995 672
1996 688
1997 757
1998 715
1999 809
2000 916
2001 904
2002 1059
2003 1067
2004 1272
2005 1507
2006 1636
2007 1789
2008 2029
2009 2368
2010 2423
2011 2770
2012 3283
2013 3422
2014 3574
2015 3711
2016 3623
2017 3660
2018 3625
2019 1455
2020 12
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49,062 results
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Page 1
Effectiveness of resistance exercise compared to aerobic exercise without insulin therapy in patients with type 2 diabetes mellitus: a meta-analysis.
Nery C, et al. Braz J Phys Ther 2017 - Review. PMID 28728958 Free PMC article.
BACKGROUND: Physical exercise has been used to mitigate the metabolic effects of diabetes mellitus. OBJECTIVE: To evaluate the effect of resistance exercise when compared to aerobic exercise without insulin therapy on metabolic and clinical outcomes in patients with type 2 diabetes mellitus. ...Clinical trials that compared resistance exercise to aerobic exercise in adults with type 2 diabetes mellitus who did not use insulin therapy were included. ...
BACKGROUND: Physical exercise has been used to mitigate the metabolic effects of diabetes mellitus. OBJECTIVE: To evaluate the …
The Effectiveness of Continuous Glucose Monitoring in Patients with Type 2 Diabetes: A Systematic Review of Literature and Meta-analysis.
Park C and Le QA. Diabetes Technol Ther 2018. PMID 30095980
Currently, the evidence on effectiveness of CGM in patients with type 2 diabetes is debatable. We aim to provide a systematic review and meta-analysis to synthesize current evidence of effectiveness of CGM in adults with type 2 diabetes. ...CONCLUSION: Our analysis of current evidence suggests that RT-CGM and P-CGM are effective in improving HbA1c in adults with type 2 diabetes. ...
Currently, the evidence on effectiveness of CGM in patients with type 2 diabetes is debatable. We aim to provide a syst …
[Diabetes Mellitus Type 2: Recent Publications and New Drugs].
Elbelt U. Dtsch Med Wochenschr 2018. PMID 29807374 German.
These trails were designed to demonstrate non-inferiority to placebo with regard to cardiovascular safety for patients with type 2 diabetes mellitus at high cardiovascular risk.For the glucagon-like peptide 1 (GLP-1)-receptor agonists liraglutide and semaglutide as well as for the sodium-glucose cotransporter-2 (SGLT-2) inhibitors empagliflozin and canagliflozin statistically significant reductions of the primary composite outcome (nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death) were demonstrated. Cardiovascular outcomes trails for the dipeptidyl peptidase-4 (DPP-4) inhibitors saxagliptin, alogliptin, and sitagliptin did not show statistically significant differences for major cardiovascular events between treatment and placebo groups.Therefore, for patients with established cardiovascular disease who do not achieve sufficient blood glucose control on metformin monotherapy GLP-1-receptor agonists and SGLT-2 inhibitors should be favoured for diabetes therapy intensification. ...
These trails were designed to demonstrate non-inferiority to placebo with regard to cardiovascular safety for patients with type 2
Toll-like receptor 2 and type 2 diabetes.
Sepehri Z, et al. Cell Mol Biol Lett 2016 - Review. PMID 28536605 Free PMC article.
Several DAMPs are released during type 2 diabetes, so it may be hypothesized that TLR2 is significantly involved in its progression. Here, we review recent data on the important roles and status of TLR2 in type 2 diabetes and related complications....
Several DAMPs are released during type 2 diabetes, so it may be hypothesized that TLR2 is significantly involved in its …
The role of type 2 diabetes in neurodegeneration.
Verdile G, et al. Neurobiol Dis 2015 - Review. PMID 25926349
A growing body of evidence links type-2 diabetes (T2D) with dementia and neurodegenerative diseases such as Alzheimer's disease (AD). ...The evaluation of treatments for the management of diabetes in preclinical, and clinical studies and trials for AD will also be discussed....
A growing body of evidence links type-2 diabetes (T2D) with dementia and neurodegenerative diseases such as Alzheimer's …
Translating aetiological insight into sustainable management of type 2 diabetes.
Taylor R and Barnes AC. Diabetologia 2018 - Review. PMID 29143063 Free PMC article.
Using a low-energy diet as a tool, it has been possible to elucidate the sequence of pathophysiological changes that lead to the onset of type 2 diabetes. Negative energy balance in type 2 diabetes causes a profound fall in liver fat content resulting in normalisation of hepatic insulin sensitivity within 7 days. ...
Using a low-energy diet as a tool, it has been possible to elucidate the sequence of pathophysiological changes that lead to the onset of …
Insulin resistance and glycine metabolism in humans.
Adeva-Andany M, et al. Amino Acids 2018 - Review. PMID 29094215
In prospective studies, hypoglycinemia at baseline predicts the risk of developing type 2 diabetes and higher serum glycine level is associated with decreased risk of incident type 2 diabetes. Consistently, plasma glycine concentration is lower in the lean offspring of parents with type 2 diabetes compared to healthy subjects. ...
In prospective studies, hypoglycinemia at baseline predicts the risk of developing type 2 diabetes and higher serum gly …
Serum metabolic profiling of type 2 diabetes mellitus in Chinese adults using an untargeted GC/TOFMS.
Wang H, et al. Clin Chim Acta 2018. PMID 29197503
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a huge burden in China. The Chinese patients with T2DM have several special clinical characteristics. ...To further analyze the correlation between the identified metabolites and T2DM, 17 metabolites were selected with FC>2.0, including gentisic acid, citraconic acid, succinic acid, 2-hydroxybutanoic acid and 3-hydroxy-l-proline, the corresponding FC were respectively 5.44, 2.21, 2.10, 2.21 and -2.04. ...
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a huge burden in China. The Chinese patients with T2DM have sever …
Comparative study of the effects of ipragliflozin and sitagliptin on multiple metabolic variables in Japanese patients with type 2 diabetes: A multicentre, randomized, prospective, open-label, active-controlled study.
Tsurutani Y, et al. Diabetes Obes Metab 2018 - Clinical Trial. PMID 29893003
In the present randomized study, we assessed the efficacy of ipragliflozin compared with sitagliptin in 124 Japanese patients with type 2 diabetes. ...In conclusion, ipragliflozin had beneficial effects on fat reduction, insulin resistance and lipid metabolism, while sitagliptin had beneficial effects on β-cell function....
In the present randomized study, we assessed the efficacy of ipragliflozin compared with sitagliptin in 124 Japanese patients with type
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.
Li N, et al. Eur J Med Chem 2018 - Review. PMID 29609120
Diabetes is a fast growing chronic metabolic disorder around the world. Dipeptidyl peptidase-4 (DPP-4) is a new promising target during type 2 diabetes glycemic control. Thus, a number of potent DPP-4 inhibitors were developed and play a rapidly evolving role in the management of type 2 diabetes in recent years. ...
Diabetes is a fast growing chronic metabolic disorder around the world. Dipeptidyl peptidase-4 (DPP-4) is a new promising target duri
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