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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 7
1947 8
1948 12
1949 14
1950 5
1951 13
1952 10
1953 12
1954 18
1955 18
1956 7
1957 20
1958 22
1959 17
1960 14
1961 20
1962 25
1963 31
1964 41
1965 54
1966 48
1967 59
1968 50
1969 52
1970 47
1971 49
1972 49
1973 53
1974 46
1975 42
1976 36
1977 42
1978 47
1979 57
1980 58
1981 51
1982 54
1983 43
1984 60
1985 63
1986 44
1987 50
1988 53
1989 63
1990 64
1991 72
1992 73
1993 79
1994 70
1995 66
1996 53
1997 86
1998 76
1999 67
2000 85
2001 56
2002 61
2003 46
2004 69
2005 69
2006 63
2007 70
2008 69
2009 78
2010 72
2011 80
2012 79
2013 83
2014 95
2015 71
2016 54
2017 60
2018 45
2019 23
2020 0
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3,503 results
Results by year
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Page 1
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Gilbert LA, et al. Cell 2014. PMID 25307932 Free PMC article.
Screens for sensitivity to a cholera-diphtheria toxin provide broad insights into the mechanisms of pathogen entry, retrotranslocation and toxicity. ...
Screens for sensitivity to a cholera-diphtheria toxin provide broad insights into the mechanisms of pathogen entry, retrotrans …
Immunotoxins in cancer therapy: Review and update
Akbari B, et al. Int Rev Immunol 2017 - Review. PMID 28282218
Here, we discuss the advantages and limitations of bacterial toxins such as Pseudomonas and Diphtheria toxins, plant toxins such as ricin and gelonin, and some endogenous protein of human origin such as RNases and Granzymes. ...ABBREVIATIONS: mAbs: Monoclonal antibodies; EF2: elongation factor 2; ITs: Immunotoxins; DT: Diphtheria toxin; PE: Pseudomonas exotoxin; dgA: de-glycosylated A-chain of ricin; rGel: recombinant de-glycosylated form of gelonin; NKC: natural killer cells; HTR: human transferrin receptor; EGF: epidermal growth factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; DAB389: truncated Diphtheria toxin; B-CCL: B-cell chronic lymphocytic leukemia; RCC: renal cell carcinoma; GVHD: Graft-versus-host disease; EGFR: epidermal growth factor receptor; AML: acute myeloid leukemia; Fab: fragment antigen-binding; dsFv: disulfide-stabilized fragment variable; scFv: single-chain fragment variable; B-ALL: B-lineage Acute Lymphoblastic Leukemia; Fv: fragment variable; HCL: hairy cell leukemia; IL-2R: Interleukin-2 receptor; CR: complete response; CLL: chronic lymphocytic leukemia; ATL: adult T-cell leukemia; DARPins: designed Ankyrin repeat proteins; pmol: picomolar; HAMA: human-anti mouse antibody....
Here, we discuss the advantages and limitations of bacterial toxins such as Pseudomonas and Diphtheria toxins, plant toxins such as r …
Tagraxofusp: First Global Approval
Syed YY. Drugs 2019 - Review. PMID 30859413
Tagraxofusp (tagraxofusp-erzs) [Elzonris™] is an intravenously administered CD123-directed cytotoxin (composed of human interleukin-3 and a truncated diphtheria toxin payload) that was developed by Stemline Therapeutics, Inc. for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN). ...
Tagraxofusp (tagraxofusp-erzs) [Elzonris™] is an intravenously administered CD123-directed cytotoxin (composed of human interleukin-3 and a …
Monoclonal Antibodies
Geskin LJ. Dermatol Clin 2015 - Review. PMID 26433849 Free article.
Diphtheria toxin-based targeted toxin therapy for brain tumors.
Li YM, et al. J Neurooncol 2013 - Review. PMID 23695514
After internalization, the toxin component kills the cell. These recombinant proteins consist of an antibody or carrier ligand coupled to a modified plant or bacterial toxin such as diphtheria toxin (DT). ...
After internalization, the toxin component kills the cell. These recombinant proteins consist of an antibody or carrier ligand couple …
Identification of a diphtheria toxin-like gene family beyond the Corynebacterium genus.
Mansfield MJ, et al. FEBS Lett 2018. PMID 30058084 Free article.
Diphtheria toxin (DT), produced by Corynebacterium diphtheria, is the causative agent of diphtheria and one of the most potent protein toxins known; however, it has an unclear evolutionary history. ...
Diphtheria toxin (DT), produced by Corynebacterium diphtheria, is the causative agent of diphtheria and one of t
Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model.
Smith HL, et al. Virulence 2016. PMID 27070129 Free PMC article.
Prompt administration of anti-toxin reduces mortality following Corynebacterium diphtheriae infection. Current treatment relies upon equine diphtheria anti-toxin (DAT), with a 10% risk of serum sickness and rarely anaphylaxis. ...S315 is a neutralizing human IgG1 monoclonal antibody to diphtheria toxin that may provide a safe and effective alternative to equine DAT and address critical supply issues. ...
Prompt administration of anti-toxin reduces mortality following Corynebacterium diphtheriae infection. Current treatment relies upon …
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages.
Pereira MM, et al. Nat Commun 2017. PMID 28367972 Free PMC article.
Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, diphtheria toxin (DT) crosses the blood-brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are also expressed in the central nervous system (CNS). ...
Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, di
Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice.
Hu L, et al. J Neurosci 2016. PMID 27605621 Free PMC article.
Here we show that HC regeneration in newborn mouse ears occurred spontaneously when the original cells were ablated by treatment with diphtheria toxin (DT) in ears that had been engineered to overexpress the DT receptor, but was not detectable when HCs were ablated in vivo by the aminoglycoside antibiotic neomycin. ...We found that HCs regenerated spontaneously in the newborn mouse after diphtheria toxin (DT)-induced, but not neomycin-induced, HC death. ...
Here we show that HC regeneration in newborn mouse ears occurred spontaneously when the original cells were ablated by treatment with dip
[Expression, purification and characterization of diphtheria toxin mutant CRM197 in Eschrichia coli].
Fang T, et al. Sheng Wu Gong Cheng Xue Bao 2018. PMID 29701029 Chinese. Free article.
CRM197 (cross-reacting material 197), a non-toxic mutant of diphtheria toxin, has wide application potential in biopharmaceuticals. ...Cytotoxicity tests showed that the IC₅₀ value of CRM197 was 2.1×10⁷ times the IC₅₀ value of diphtheria toxin, and 9.6 times the IC50 value of diphtheria toxoid, telling that the target protein is safe and non-toxic. ...
CRM197 (cross-reacting material 197), a non-toxic mutant of diphtheria toxin, has wide application potential in biopharmaceuti …
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