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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1489
1843 1121
1844 1251
1845 1278
1846 1406
1847 1368
1848 1203
1849 1208
1850 1127
1851 1228
1852 1313
1853 1558
1854 1306
1855 1587
1856 1588
1857 1488
1858 1543
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1810
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2180
1878 2455
1879 2399
1880 2646
1881 3149
1882 2742
1883 3127
1884 3049
1885 3337
1886 3291
1887 3965
1888 4002
1889 4194
1890 4024
1891 3607
1892 4080
1893 4370
1894 3801
1895 4129
1896 4412
1897 4689
1898 4631
1899 4169
1900 3785
1901 3886
1902 3967
1903 3911
1904 4059
1905 4067
1906 3872
1907 4324
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5105
1914 5135
1915 4641
1916 4543
1917 4281
1918 4568
1919 4619
1920 4960
1921 4628
1922 4123
1923 4432
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5548
1933 5611
1934 5508
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53739
1947 64968
1948 70726
1949 62805
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108543
1956 107005
1957 111515
1958 109458
1959 109989
1960 112211
1961 120167
1962 125670
1963 141520
1964 162087
1965 176643
1966 179769
1967 191523
1968 207854
1969 215081
1970 218983
1971 222927
1972 227545
1973 230654
1974 234541
1975 248269
1976 250484
1977 250250
1978 258641
1979 266054
1980 267504
1981 271856
1982 283472
1983 295240
1984 303195
1985 319333
1986 331923
1987 347909
1988 364376
1989 378683
1990 384278
1991 382690
1992 384438
1993 392887
1994 404145
1995 413532
1996 423606
1997 421726
1998 439204
1999 456654
2000 493904
2001 506447
2002 524381
2003 552025
2004 594549
2005 653882
2006 698972
2007 737026
2008 784617
2009 824408
2010 887696
2011 963810
2012 1029722
2013 1081591
2014 1135757
2015 1178761
2016 1212094
2017 1234824
2018 1278943
2019 1340399
2020 1539300
2021 1684017
2022 1684182
2023 1598056
2024 1638886
2025 683119
2026 73
2027 1

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36,690,377 results

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Page 1
Single-stranded DNA library preparation from highly degraded DNA using T4 DNA ligase.
Gansauge MT, Gerber T, Glocke I, Korlevic P, Lippik L, Nagel S, Riehl LM, Schmidt A, Meyer M. Gansauge MT, et al. Nucleic Acids Res. 2017 Jun 2;45(10):e79. doi: 10.1093/nar/gkx033. Nucleic Acids Res. 2017. PMID: 28119419 Free PMC article.
However, for highly degraded DNA, especially ancient DNA, library preparation has been found to be more efficient if each of the two DNA strands are converted into library molecules separately. We present a new method for single-stranded library preparation, ssDNA2. …
However, for highly degraded DNA, especially ancient DNA, library preparation has been found to be more efficient if each of the two DNA str …
CRISPR as a Diagnostic Tool.
Kim S, Ji S, Koh HR. Kim S, et al. Biomolecules. 2021 Aug 6;11(8):1162. doi: 10.3390/biom11081162. Biomolecules. 2021. PMID: 34439828 Free PMC article. Review.
In addition to the target-specific binding and cleavage, the trans-cleavage activity was reported for some Cas proteins, including Cas12a and Cas13a, which is to cleave the surrounding single-stranded DNA or RNA upon the target binding of Cas-gRNA complex. Al …
In addition to the target-specific binding and cleavage, the trans-cleavage activity was reported for some Cas proteins, including Cas12a an …
Single-Stranded DNA Binding Proteins and Their Identification Using Machine Learning-Based Approaches.
Guo JT, Malik F. Guo JT, et al. Biomolecules. 2022 Aug 26;12(9):1187. doi: 10.3390/biom12091187. Biomolecules. 2022. PMID: 36139026 Free PMC article. Review.
Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome stability by protecting the transient existence of ssDNA from damage during essential biological processes, such as DNA replication and gene transcription. The single …
Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome stability by protecting the tran …
Poly(oligonucleotide).
James CR, Rush AM, Insley T, Vuković L, Adamiak L, Král P, Gianneschi NC. James CR, et al. J Am Chem Soc. 2014 Aug 13;136(32):11216-9. doi: 10.1021/ja503142s. Epub 2014 Jul 31. J Am Chem Soc. 2014. PMID: 25077676 Free PMC article.
We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphi …
We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymeri …
Visualizing recombination intermediates with single-stranded DNA curtains.
Qi Z, Greene EC. Qi Z, et al. Methods. 2016 Aug 1;105:62-74. doi: 10.1016/j.ymeth.2016.03.027. Epub 2016 Mar 30. Methods. 2016. PMID: 27038747 Free PMC article. Review.
During the early stages of HR, members from the Rad51/RecA family of recombinases assemble into long filaments on the single-stranded DNA overhangs that are present at processed DSBs. These nucleoprotein filaments are referred to as presynaptic complexes, and …
During the early stages of HR, members from the Rad51/RecA family of recombinases assemble into long filaments on the single-stran …
Droplet microfluidics for single-cell analysis.
Brouzes E. Brouzes E. Methods Mol Biol. 2012;853:105-39. doi: 10.1007/978-1-61779-567-1_10. Methods Mol Biol. 2012. PMID: 22323144 Review.
The surfactant system used to stabilize droplets is a critical component of droplet microfluidics; its properties define the type of droplet-based assays and workflows that can be developed. ...The fabrication section describes the manufacturing of microfluidic chip …
The surfactant system used to stabilize droplets is a critical component of droplet microfluidics; its properties define the t …
Multifractal analysis of maize and soybean DNA.
Correia JP. Correia JP. Sci Rep. 2024 May 9;14(1):10687. doi: 10.1038/s41598-024-60722-2. Sci Rep. 2024. PMID: 38724570 Free PMC article.
The results show that maize and soybean DNA sequences exhibit fractal properties, indicating a complex and self-organizing structure. ...We also identified the stochastic nature of the DNA sequences of both species....
The results show that maize and soybean DNA sequences exhibit fractal properties, indicating a complex and self-organiz …
PNA-Pdx: Versatile Peptide Nucleic Acid-Based Detection of Nucleic Acids and SNPs.
Jiang W, Aman R, Ali Z, Rao GS, Mahfouz M. Jiang W, et al. Anal Chem. 2023 Sep 26;95(38):14209-14218. doi: 10.1021/acs.analchem.3c01809. Epub 2023 Sep 11. Anal Chem. 2023. PMID: 37696750 Free PMC article.
Monitoring diseases caused by pathogens or by mutations in DNA sequences requires accurate, rapid, and sensitive tools to detect specific nucleic acid sequences. ...PNA probes can also be designed to invade double-stranded DNAs (dsDNAs) to produce single-s …
Monitoring diseases caused by pathogens or by mutations in DNA sequences requires accurate, rapid, and sensitive tools to dete …
Droplet-based microfluidic analysis and screening of single plant cells.
Yu Z, Boehm CR, Hibberd JM, Abell C, Haseloff J, Burgess SJ, Reyna-Llorens I. Yu Z, et al. PLoS One. 2018 May 3;13(5):e0196810. doi: 10.1371/journal.pone.0196810. eCollection 2018. PLoS One. 2018. PMID: 29723275 Free PMC article.
This work opens the door to droplet-based microfluidic analysis of plant cells for applications ranging from high-throughput characterisation of DNA parts to single-cell genomics to selection of rare plant phenotypes....
This work opens the door to droplet-based microfluidic analysis of plant cells for applications ranging from high-throughput c …
Plasmid Stability Analysis with Open-Source Droplet Microfluidics.
Padilla-Huamantinco P, Durán E, Wenzel T. Padilla-Huamantinco P, et al. J Vis Exp. 2024 Dec 27;(214). doi: 10.3791/67659. J Vis Exp. 2024. PMID: 39803963
This study introduces an open-hardware-based microfluidic workflow for analyzing plasmid retention by culturing single cells in gel microdroplets and quantifying microcolonies using fluorescence microscopy. This approach allows for the parallel analysis of numerous …
This study introduces an open-hardware-based microfluidic workflow for analyzing plasmid retention by culturing single cells in gel microdro …
36,690,377 results
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